Abstract
The cell membrane also called as the plasma membrane or plasmalemma is one biological membrane that separates the interior of the cell from the outside environment. The cell membrane surrounds all cells and is selectively permeable, controlling the movement of substances in and out of cells. One of the main functions of the cell membrane is also to take messages from outside the cell (environment) and convey the same to the internal structures of the cell such as nucleus (DNA), mitochondria, etc., so that appropriate responses can be elicited from the cell to these outside stimuli. The cell contains a variety of biological molecules that include proteins, lipids and a variety of enzyme systems that are involved in various cellular processes such as adhesion, ion channel conductance and cell signaling.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002) Molecular biology of the cell, 4th edn. Garland, New York
Lodish H, Berk A, Matsudaira P, Kaiser CA, Krieger M, Scott MP, Zipurksy SL, Darnell J (2004) Molecular cell biology, 5th edn. WH Freeman, New York
Cooper GM (2000) The cell: a molecular approach, 2nd edn. ASM Press, Washington
Thomas S, Pais AP, Casares S, Brumeanu TD (2004) Analysis of lipid rafts in T cells. Mol Immunol 41:399–409
Thomas S, Kumar RS, Brumeanu TD (2004) Role of lipid rafts in T cells. AITE 52:215–224
Korade Z (2008) Lipid rafts, cholesterol, and the brain. Neuropharmacology 55:1265–1273
Pike LJ (2009) The challenge of lipid rafts. J Lipid Res 50(Suppl):S323–S328
Simons K, Ehehalt R (2002) Cholesterol, lipid rafts, and disease. J Clin Invest 110:597–603
Fantini J, Garmy N, Mahfoud R, Yahi N (2002) Lipid rafts: structure, function and role in HIV, Alzheimer’s and prion diseases. Expert Rev Mol Med 4:1–22
Rietveld A, Simons K (1998) The differential miscibility of lipids as the basis for the formation of functional membrane rafts. Biochim Biophys Acta 1376:467–479
Fivaz M, Abrami L, van der Goot FG (1999) Landing on lipid rafts. Trends Cell Biol 9:212–213
Heerklotz H (2002) Triton promotes domain formation in lipid raft mixtures. Biophys J 83:2693–2701
Simons K, Ikonen E (1997) Functional rafts in cell membranes. Nature 387:569–572
Allen JA (2007) Lipid raft microdomains and neurotransmitter signalling. Nature 8:128–140
Kurzchalia TV, Parton RG (1999) Membrane microdomains and caveolae. Curr Opin Cell Biol 11:424–431
Janes PW, Ley SC, Magee AI, Kabouridis PS (2000) The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin Immunol 12:23–24
Schmitz G, Grandl M (2008) Update on lipid membrane microdomains. Curr Opin Clin Nutr Metab Care 11:106–112
Ilangumaran S, Borisch B, Hoessli DC (1999) Signal transduction via CD44: role of plasma membrane microdomains. Leuk Lymphoma 35:455–469
Kail S, Derek T (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31–39
Brown DA, London E (2000) Structure and function of sphingolipid- and cholesterol-rich membrane rafts. J Biol Chem 275:17221–17224
Brown DA, London E (1998) Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111–136
Brown D (2002) Structure and function of membrane rafts. Int J Med Microbiol 291:433–437
Lingwood D, Simons K (2010) Lipid rafts as a membrane-organizing principle. Science 327:46–50
Taghibiglou C, Bradley CA, Gaertner T, Li Y, Wang Y, Wang YT (2009) Mechanisms involved in cholesterol-induced neuronal insulin resistance. Neuropharmacology 57:268–276
Rivera M, Muto A, Feigel A, Kondo Y, Dardik A (2009) Venous and arterial identity: a role for caveolae? Vascular 17(Suppl 1):S10–S14
Lajoie P, Goetz JG, Dennis JW, Nabi IR (2009) Lattices, rafts, and scaffolds: domain regulation of receptor signaling at the plasma membrane. J Cell Biol 185:381–385
Kinoshita MO, Furuya S, Ito S, Shinoda Y, Yamazaki Y, Greimel P, Ito Y, Hashikawa T, Machida T, Nagatsuka Y, Hirabayashi Y (2009) Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors. Biochem J 419:565–575
Field KA, Holowka D, Baird B (1995) FceRI-mediated recruitment of p53/561yn to detergent-resistant membrane domains accompanies cellular signaling. Proc Natl Acad Sci U S A 92:9201–9205
Sheets ED, Holowka D, Baird B (1999) Membrane organization in immunoglobulin E receptor signaling. Curr Opin Chem Biol 3:95–99
Baird B, Sheets ED, Holowka D (1999) How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E? Biophys Chem 82:109–119
Field KA, Holowka D, Baird B (1995) FceRI-mediated recruitment of p53/561yn to detergent-resistant membrane domains accompanies cellular signaling. Proc Natl Acad Sci U S A 92:9201–9205
Goitsuka R, Kanazashi H, Sasanuma H, Fujimura Y, Hidaka Y, Tatsuno A, Ra C, Hayashi K, Kitamura D (2000) A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation. Int Immunol 12:573–580
Janes PW, Ley SC, Magee AI, Kabouridis PS (2000) The role of lipid rafts in T cell antigen receptor (TCR) signalling. Semin Immunol 12:23–24
Langlet C, Bernard A-M, Drevot P, He H-T (2000) Membrane rafts and signaling by the multichain immune recognition receptors. Curr Opin Immunol 12:250–255
Zhang W, Trible RP, Samelson LE (1998) LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9:239–246
Brdi kab T, Jan erný, Ho ej ía V (1998) T cell receptor signalling results in rapid tyrosine phosphorylation of the linker protein LAT present in detergent-resistant mMembrane microdomains. Biochem Biophys Res Commun 248:356–360
Carl LA, Cooper JA (2000) Signal transduction: molecular switches in lipid rafts. Nature 404:945–947
Luo C, Wang K, Liu de Q, Li Y, Zhao QS (2008) The functional roles of lipid rafts in T cell activation, immune diseases and HIV infection and prevention. Cell Mol Immunol 5:1–7
Wang XM, Nadeau PE, Lo YT, Mergia A (2010) Caveolin-1 modulates HIV-1 envelope induced bystander apoptosis through gp41. J Virol 84:6515–6526
Gupta N, DeFranco AL (2007) Lipid rafts and B cell signaling. Semin Cell Dev Biol 18:616–626
Gupta N, DeFranco AL (2003) Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell 14:432–444
Sharma P, Varma R, Sarasij RC, Ira, Gousset K, Krishnamoorthy G, Rao M, Mayor S (2004) Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. Cell 116:577–589
Anderson RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199–225
Frank P, Lisanti M (2004) Caveolin-1 and caveolae in atherosclerosis: differential roles in fatty streak formation and neointimal hyperplasia. Curr Opin Lipidol 15:523–529
Li X, Everson W, Smart E (2005) Caveolae, lipid rafts, and vascular disease. Trends Cardiovasc Med 15:92–96
Pelkmans L (2005) Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses. Biochim Biophys Acta 1746:295–304
Bruno MJ, Koeppe RE 2nd, Andersen OS (2007) Docosahexaenoic acid alters bilayer elastic properties. Proc Natl Acad Sci U S A 104:9638–9643
Kim W, Fan YY, Barhoumi R, Smith R, McMurray DN, Chapkin RS (2008) n-3 polyunsaturated fatty acids suppress the localization and activation of signaling proteins at the immunological synapse in murine CD4+ T cells by affecting lipid raft formation. J Immunol 181:6236–6243
Ma DW, Seo J, Davidson LA, Callaway ES, Fan YY, Lupton JR, Chapkin RS (2004) n-3 PUFA alter caveolae lipid composition and resident protein localization in mouse colon. FASEB J 18:1040–1042
Fan YY, McMurray DN, Ly LH, Chapkin RS (2003) Dietary (n-3) polyunsaturated fatty acids remodel mouse T-cell lipid rafts. J Nutr 133:1913–1920
Fan YY, Ly LH, Barhoumi R, McMurray DN, Chapkin RS (2004) Dietary docosahexaenoic acid suppresses T cell protein kinase C theta lipid raft recruitment and IL-2 production. J Immunol 173:6151–6160
Bousserouel S, Raymondjean M, Brouillet A, Béréziat G, Andréani M (2004) Modulation of cyclin D1 and early growth response factor-1 gene expression in interleukin-1beta-treated rat smooth muscle cells by n-6 and n-3 polyunsaturated fatty acids. Eur J Biochem 271:4462–4473
Li Q, Zhang Q, Wang M, Zhao S, Ma J, Luo N, Li N, Li Y, Xu G, Li J (2007) Eicosapentaenoic acid modifies lipid composition in caveolae and induces translocation of endothelial nitric oxide synthase. Biochimie 89:169–177
Chen W, Jump DB, Esselman WJ, Busik JV (2007) Inhibition of cytokine signaling in human retinal endothelial cells through modification of caveolae/lipid rafts by docosahexaenoic acid. Invest Ophthalmol Vis Sci 48:18–26
Li Q, Zhang Q, Wang M, Liu F, Zhao S, Ma J, Luo N, Li N, Li Y, Xu G, Li J (2007) Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. Arch Biochem Biophys 466:250–259
Wang L, Lim EJ, Toborek M, Hennig B (2008) The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. Metabolism 57:1328–1339
Das UN (2002) A perinatal strategy for preventing adult diseases: the role of long-chain polyunsaturated fatty acids. Kluwer Academic, Boston
Das UN (2010) Metabolic syndrome pathophysiology: the role of essential fatty acids. Wiley-Blackwell, Ames
Das UN (2006) Essential fatty acids: biochemistry, physiology, and pathology. Biotechnol J 1:420–439
Das UN (2006) Essential fatty acids—a review. Curr Pharm Biotechnol 7:467–482
Das UN (2006) Biological significance of essential fatty acids. J Assoc Physicians India 54:309–319
Das UN (2004) Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-β to prevent human essential hypertension. Eur J Clin Nutr 58:195–203
Das UN, Puskás LG (2009) Transgenic fat-1 mouse as a model to study the pathophysiology of cardiovascular, neurological and psychiatric disorders. Lipids Health Dis 8:61
Das UN (2008) Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis 7:37
Das UN (2008) Can endogenous lipid molecules serve as predictors and prognostic markers of coronary heart disease? Lipids Health Dis 7:19
Das UN (2008) Can essential fatty acids reduce the burden of disease(s)? Lipids Health Dis 7:9
Das UN (2007) A defect in the activity of Delta6 and Delta5 desaturases may be a factor in the initiation and progression of atherosclerosis. Prostaglandins Leukot Essent Fatty Acids 76:251–268
Das UN (1999) Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins Leukot Essent Fatty Acids 61:157–163
Das UN (1983) Prostaglandins and gene action. Med Hypotheses 11:185–194
Benavente J, Esteban M, Jaffe BM, Santoro MG (1984) Selective inhibition of viral gene expression as the mechanism of the antiviral action of PGA1 in vaccinia virus-infected cells. J Gen Virol 65(Pt 3):599–608
Ishioka C, Kanamaru R, Sato T, Dei T, Konishi Y, Asamura M, Wakui A (1988) Inhibitory effects of prostaglandin A2 on c-myc expression and cell cycle progression in human leukemia cell line HL-60. Cancer Res 48:2813–2818
Marui N, Sakai T, Hosokawa N, Yoshida M, Aoike A, Kawai K, Nishino H, Fukushima M (1990) N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. FEBS Lett 270:15–18
Acarregui MJ, Snyder JM, Mitchell MD, Mendelson CR (1990) Prostaglandins regulate surfactant protein A (SP-A) gene expression in human fetal lung in vitro. Endocrinology 127:1105–1113
Khan I, Hossain A, Whitman GF, Sarkar NH, McDonough PG (1993) Differential induction of c-jun expression by PGF2-alpha in rat ovary, uterus and adrenal. Prostaglandins 46:139–144
Anastassiou ED, Paliogianni F, Balow JP, Yamada H, Boumpas DT (1992) Prostaglandin E2 and other cyclic AMP-elevating agents modulate IL-2 and IL-2R alpha gene expression at multiple levels. J Immunol 148:2845–2852
Desanctis JB, Varesio L, Radzioch D (1994) Prostaglandins inhibit lipoprotein lipase gene expression in macrophages. Immunology 81:605–610
Bui T, Kuo C, Rotwein P, Straus DS (1997) Prostaglandin A2 specifically represses insulin-like growth factor-I gene expression in C6 rat glioma cells. Endocrinology 138:985–993
Walton SL, Burne TH, Gilbert CL (2002) Prostaglandin F2alpha-induced nest-building behaviour is associated with increased hypothalamic c-fos and c-jun mRNA expression. J Neuroendocrinol 14:711–723
Tang CH, Yang RS, Fu WM (2005) Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase C alpha, and c-Src pathway in primary cultured rat osteoblasts. J Biol Chem 280:22907–22916
Kim CH, Park YG, Noh SH, Kim YK (2005) PGE2 induces the gene expression of bone matrix metalloproteinase-1 in mouse osteoblasts by cAMP-PKA signaling pathway. Int J Biochem Cell Biol 37:375–385
Huang JC, Wun WS, Goldsby JS, Egan K, FitzGerald GA, Wu KK (2007) Prostacyclin receptor signaling and early embryo development in the mouse. Hum Reprod 22:2851–2856
Fang IM, Yang CH, Yang CM, Chen MS (2007) Linoleic acid-induced expression of inducible nitric oxide synthase and cyclooxygenase II via p42/44 mitogen-activated protein kinase and nuclear factor-kappaB pathway in retinal pigment epithelial cells. Exp Eye Res 85:667–677
Renedo M, Gayarre J, García-Domínguez CA, Pérez-Rodríguez A, Prieto A, Cañada FJ, Rojas JM, Pérez-Sala D (2007) Modification and activation of Ras proteins by electrophilic prostanoids with different structure are site-selective. Biochemistry 46:6607–6616
Stanley DW, Goodman C, An S, McIntosh A, Song Q (2008) Prostaglandins A1 and E1 influence gene expression in an established insect cell line (BCIRL-HzAM1 cells). Insect Biochem Mol Biol 38:275–284
Yamada T (2009) Regulation of the expression of inducible nitric oxide synthase by prostanoids. Yakugaku Zasshi 129:1211–1214
Marei WF, Wathes DC, Fouladi-Nashta AA (2009) The effect of linolenic Acid on bovine oocyte maturation and development. Biol Reprod 81:1064–1072
Das UN (2011) Influence of polyunsaturated fatty acids and their metabolites on stem cell biology. Nutrition 27:21–25
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2011 Springer Netherlands
About this chapter
Cite this chapter
Das, U.N. (2011). Cell Membrane Organization. In: Molecular Basis of Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0495-4_5
Download citation
DOI: https://doi.org/10.1007/978-94-007-0495-4_5
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-0494-7
Online ISBN: 978-94-007-0495-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)