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Glioblastoma: Endosialin Marker for Pericytes

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Tumors of the Central Nervous System, Volume 1

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 1))

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Abstract

Glioblastoma multiforme (GBM) is characterized by extensive microvascular proliferations. This abnormal vasculature is a potential target for anti-angiogenic therapy. Here, we describe the current literature on a novel target for antibody-based therapy, endosialin (CD248/TEM1). This type I transmembrane protein is often observed in the tumor vasculature of GBM patients, but absent in normal, mature vessels of the brain. We describe the protein structure, regulation of expression and potential function of endosialin, and pay particular attention to the cell type distribution of endosialin in GBM vasculature, which we identified to be limited to pericytes.

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Authors and Affiliations

  1. The Netherlands Cancer Institute, Amsterdam, CX, 1066, The Netherlands

    Nicole Simonavicius, Clare M. Isacke & Ivo J. Huijbers

Authors
  1. Nicole Simonavicius
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  2. Clare M. Isacke
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  3. Ivo J. Huijbers
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Corresponding author

Correspondence to Ivo J. Huijbers .

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Editors and Affiliations

  1. Dept. Biological Sciences, Kean University, 1000 Moris Avenue, Union, 07083, New Jersey, USA

    M. A. Hayat

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Simonavicius, N., Isacke, C.M., Huijbers, I.J. (2011). Glioblastoma: Endosialin Marker for Pericytes. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 1. Tumors of the Central Nervous System, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0344-5_3

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  • DOI: https://doi.org/10.1007/978-94-007-0344-5_3

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