Skip to main content
SpringerLink
Log in

TRPV5 and TRPV6 in Transcellular Ca2+ Transport: Regulation, Gene Duplication, and Polymorphisms in African Populations

  • Chapter
  • First Online:
Book cover Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

TRPV5 and TRPV6 are unique members of the TRP super family. They are highly selective for Ca2+ ions with multiple layers of Ca2+-dependent inactivation mechanisms, expressed at the apical membrane of Ca2+ transporting epithelia, and robustly responsive to 1,25-dihydroxivitamin D3. These features are well suited for their roles as Ca2+ entry channels in the first step of transcellular Ca2+ transport pathways, which are involved in intestinal absorption, renal reabsorption of Ca2+, placental transfer of Ca2+ to fetus, and many other processes. While TRPV6 is more broadly expressed in a variety of tissues such as esophagus, stomach, small intestine, colon, kidney, placenta, pancreas, prostate, uterus, salivary gland, and sweat gland, TRPV5 expression is relatively restricted to the distal convoluted tubule and connecting tubule of the kidney. There is only one TRPV6-like gene in fish and birds in comparison to both TRPV5 and TRPV6 genes in mammals, indicating TRPV5 gene was likely generated from duplication of TRPV6 gene during the evolution of mammals to meet the needs of complex renal function. TRPV5 and TRPV6 are subjected to vigorous regulations under physiological, pathological, and therapeutic conditions. The elevated TRPV6 level in malignant tumors such as prostate and breast cancers makes it a potential therapeutic target. TRPV6, and to a lesser extent TRPV5, exhibit unusually high levels of single nucleotide polymorphisms (SNPs) in African populations as compared to other populations, indicating TRPV6 gene was under selective pressure during or after humans migrated out of Africa. The SNPs of TRPV6 and TRPV5 likely contribute to the Ca2+ conservation mechanisms in African populations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Suzuki Y, Landowski CP, Hediger MA (2008) Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annu Rev Physiol 70:257–271

    CAS  PubMed  Google Scholar 

  2. Boros S, Bindels RJ, Hoenderop JG (2009, May) Active Ca2+ reabsorption in the connecting tubule. Pflugers Arch 458(1):99–109

    CAS  PubMed  Google Scholar 

  3. De GT, Bindels RJ, Hoenderop JG (2008, Nov) TRPV5: an ingeniously controlled calcium channel. Kidney Int 74(10):1241–1246

    Google Scholar 

  4. Hoenderop JG, Bindels RJ (2008, Feb) Calciotropic and magnesiotropic TRP channels. Physiology (Bethesda) 23:32–40

    CAS  Google Scholar 

  5. van de Graaf SF, Bindels RJ, Hoenderop JG (2007) Physiology of epithelial Ca2+ and Mg2+ transport. Rev Physiol Biochem Pharmacol 158:77–160

    PubMed  Google Scholar 

  6. Topala CN, Bindels RJ, Hoenderop JG (2007, July) Regulation of the epithelial calcium channel TRPV5 by extracellular factors. Curr Opin Nephrol Hypertens 16(4):319–324

    CAS  PubMed  Google Scholar 

  7. Schoeber JP, Hoenderop JG, Bindels RJ (2007, Feb) Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. Biochem Soc Trans 35(Pt 1):115–119

    CAS  PubMed  Google Scholar 

  8. van de Graaf SF, Hoenderop JG, Bindels RJ (2006, June) Regulation of TRPV5 and TRPV6 by associated proteins. Am J Physiol Renal Physiol 290(6):F1295–F1302

    PubMed  Google Scholar 

  9. Bodding M (2007, Mar) TRP proteins and cancer. Cell Signal 19(3):617–624

    PubMed  Google Scholar 

  10. Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG (2008) Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway. Digestion 77(1):22–34

    CAS  PubMed  Google Scholar 

  11. Vriens J, Appendino G, Nilius B (2009, June) Pharmacology of vanilloid transient receptor potential cation channels. Mol Pharmacol 75(6):1262–1279

    CAS  PubMed  Google Scholar 

  12. Vennekens R, Owsianik G, Nilius B (2008) Vanilloid transient receptor potential cation channels: an overview. Curr Pharm Des 14(1):18–31

    CAS  PubMed  Google Scholar 

  13. Hoenderop JG, van der Kemp AW, Hartog A, van de Graaf SF, van Os CH, Willems PH, Bindels RJ (1999, Mar) Molecular identification of the apical Ca2+ channel in 1, 25-dihydroxyvitamin D3-responsive epithelia. J Biol Chem 274(13):8375–8378

    CAS  PubMed  Google Scholar 

  14. Peng JB, Chen XZ, Berger UV, Vassilev PM, Tsukaguchi H, Brown EM, Hediger MA (1999, Aug) Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption. J Biol Chem 274(32):22739–22746

    CAS  PubMed  Google Scholar 

  15. Peng JB, Chen XZ, Berger UV, Vassilev PM, Brown EM, Hediger MA (2000, Sep) A rat kidney-specific calcium transporter in the distal nephron. J Biol Chem 275(36): 28186–28194

    CAS  PubMed  Google Scholar 

  16. Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ (2000, July) Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1). Genomics 67(1):48–53

    CAS  PubMed  Google Scholar 

  17. Wissenbach U, Niemeyer BA, Fixemer T, Schneidewind A, Trost C, Cavalie A, Reus K, Meese E, Bonkhoff H, Flockerzi V (2001, June) Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J Biol Chem 276(22):19461–19468

    CAS  PubMed  Google Scholar 

  18. Barley NF, Howard A, O’Callaghan D, Legon S, Walters JR (2001, Feb) Epithelial calcium transporter expression in human duodenum. Am J Physiol Gastrointest Liver Physiol 280(2):G285–G290

    CAS  PubMed  Google Scholar 

  19. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius. D (1997, Oct) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389(6653):816–824

    CAS  PubMed  Google Scholar 

  20. Colbert HA, Smith TL, Bargmann CI (1997, Nov) OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans. J Neurosci 17(21):8259–8269

    CAS  PubMed  Google Scholar 

  21. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999, Apr) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398(6726):436–441

    CAS  PubMed  Google Scholar 

  22. Kanzaki M, Zhang YQ, Mashima H, Li L, Shibata H, Kojima I (1999, July) Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I. Nat Cell Biol 1(3):165–170

    CAS  PubMed  Google Scholar 

  23. Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000, Oct) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2(10):695–702

    CAS  PubMed  Google Scholar 

  24. Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S (October 2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103(3):525–535

    PubMed Central  CAS  PubMed  Google Scholar 

  25. Wissenbach U, Bodding M, Freichel M, Flockerzi V (2000, Nov) Trp12, a novel Trp related protein from kidney. FEBS Lett 485(2–3):127–134

    CAS  PubMed  Google Scholar 

  26. Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN (2001, Jan) Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics 4(3):165–174

    CAS  PubMed  Google Scholar 

  27. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB (2002, July) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418(6894):186–190

    CAS  PubMed  Google Scholar 

  28. Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE (2002, July) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418(6894):181–186

    CAS  PubMed  Google Scholar 

  29. Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A (2002, June) A heat-sensitive TRP channel expressed in keratinocytes. Science 296(5575):2046–2049

    CAS  PubMed  Google Scholar 

  30. Kahn-Kirby AH, Bargmann. CI (2006) TRP channels in C. elegans. Annu Rev Physiol 68:719–736

    CAS  PubMed  Google Scholar 

  31. Qiu A, Hogstrand C (2004, Nov) Functional characterisation and genomic analysis of an epithelial calcium channel (ECaC) from pufferfish, Fugu rubripes. Gene 342(1):113–123

    CAS  PubMed  Google Scholar 

  32. Peng JB, Brown EM, Hediger MA (2001, Aug) Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics 76(1–3):99–109

    CAS  PubMed  Google Scholar 

  33. Dantzler WH, Braun EJ (1980, Sep) Comparative nephron function in reptiles, birds, and mammals. Am J Physiol 239(3):R197–R213

    CAS  PubMed  Google Scholar 

  34. Peng JB, Chen XZ, Berger UV, Weremowicz S, Morton CC, Vassilev PM, Brown EM, Hediger MA (2000, Nov) Human calcium transport protein CaT1. Biochem Biophys Res Commun 278(2):326–332

    CAS  PubMed  Google Scholar 

  35. Zhuang L, Peng JB, Tou L, Takanaga H, Adam RM, Hediger MA, Freeman MR (2002, Dec) Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest 82(12):1755–1764

    CAS  PubMed  Google Scholar 

  36. Wilkens MR, Kunert-Keil C, Brinkmeier H, Schroder B (2009, Nov) Expression of calcium channel TRPV6 in ovine epithelial tissue. Vet J 182(2):294–300

    CAS  PubMed  Google Scholar 

  37. Rourke KM, Coe S, Kohn CW, Rosol TJ, Mendoza FJ, Toribio RE (2010, May) Cloning, comparative sequence analysis and mRNA expression of calcium transporting genes in horses. Gen Comp Endocrinol 167(1):6–10

    CAS  PubMed  Google Scholar 

  38. Schroder B, Vossing S, Breves G (1999, Oct) In vitro studies on active calcium absorption from ovine rumen. J Comp Physiol B 169(7):487–494

    CAS  PubMed  Google Scholar 

  39. Song Y, Peng X, Porta A, Takanaga H, Peng JB, Hediger MA, Fleet JC, Christakos S (2003, Sep) Calcium transporter 1 and epithelial calcium channel messenger ribonucleic acid are differentially regulated by 1,25 dihydroxyvitamin D3 in the intestine and kidney of mice. Endocrinology 144(9):3885–3894

    CAS  PubMed  Google Scholar 

  40. Van Cromphaut SJ, Dewerchin M, Hoenderop JG, Stockmans I, Van HE, Kato S, Bindels RJ, Collen D, Carmeliet P, Bouillon R, Carmeliet G (2001, Nov) Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci USA 98(23):13324–13329

    PubMed Central  PubMed  Google Scholar 

  41. Loffing J, Loffing-Cueni D, Valderrabano V, Klausli L, Hebert SC, Rossier BC, Hoenderop JG, Bindels RJ, Kaissling B (2001, Dec) Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron. Am J Physiol Renal Physiol 281(6): F1021–F1027

    CAS  PubMed  Google Scholar 

  42. Suzuki M, Ishibashi K, Ooki G, Tsuruoka S, Imai M (2000, Aug) Electrophysiologic characteristics of the Ca-permeable channels, ECaC and CaT, in the kidney. Biochem Biophys Res Commun 274(2):344–349

    CAS  PubMed  Google Scholar 

  43. Nijenhuis T, Hoenderop JG, van der Kemp AW, Bindels RJ (2003, Nov) Localization and regulation of the epithelial Ca2+ channel TRPV6 in the kidney. J Am Soc Nephrol 14(11):2731–2740

    CAS  PubMed  Google Scholar 

  44. Nilius B, Vennekens R, Prenen J, Hoenderop JG, Bindels RJ, Droogmans G (2000, Sep) Whole-cell and single channel monovalent cation currents through the novel rabbit epithelial Ca2+ channel ECaC. J Physiol 527(Pt 2):239–248

    PubMed Central  CAS  PubMed  Google Scholar 

  45. Yue L, Peng JB, Hediger MA, Clapham DE (2001, Apr) CaT1 manifests the pore properties of the calcium-release-activated calcium channel. Nature 410(6829):705–709

    CAS  PubMed  Google Scholar 

  46. Vassilev PM, Peng JB, Hediger MA, Brown EM (2001, Nov) Single-channel activities of the human epithelial Ca2+ transport proteins CaT1 and CaT2. J Membr Biol 184(2):113–120

    CAS  PubMed  Google Scholar 

  47. Vennekens R, Hoenderop JG, Prenen J, Stuiver M, Willems PH, Droogmans G, Nilius B, Bindels RJ (2000, Feb) Permeation and gating properties of the novel epithelial Ca2+ channel. J Biol Chem 275(6):3963–3969

    CAS  PubMed  Google Scholar 

  48. Hoenderop JG, Voets T, Hoefs S, Weidema F, Prenen J, Nilius B, Bindels RJ (2003, Feb) Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J 22(4):776–785

    PubMed Central  CAS  PubMed  Google Scholar 

  49. Erler I, Hirnet D, Wissenbach U, Flockerzi V, Niemeyer BA (2004, Aug) Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem 279(33):34456–34463

    CAS  PubMed  Google Scholar 

  50. Chang Q, Gyftogianni E, van de Graaf SF, Hoefs S, Weidema FA, Bindels RJ, Hoenderop JG (2004, Dec) Molecular determinants in TRPV5 channel assembly. J Biol Chem 279(52):54304–54311

    CAS  PubMed  Google Scholar 

  51. Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R (2008, Feb) Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry 47(8): 2476–2484

    PubMed Central  CAS  PubMed  Google Scholar 

  52. Voets T, Janssens A, Droogmans G, Nilius B (2004, Apr) Outer pore architecture of a Ca2+-selective TRP channel. J Biol Chem 279(15):15223–15230

    CAS  PubMed  Google Scholar 

  53. Nilius B, Vennekens R, Prenen J, Hoenderop JG, Droogmans G, Bindels RJ (2001, Jan) The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel. J Biol Chem 276(2):1020–1025

    CAS  PubMed  Google Scholar 

  54. Dodier Y, Banderali U, Klein H, Topalak O, Dafi O, Simoes M, Bernatchez G, Sauve R, Parent L (2004, Feb) Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis. J Biol Chem 279(8):6853–6862

    CAS  PubMed  Google Scholar 

  55. Dodier Y, Dionne F, Raybaud A, Sauve R, Parent L (2007, Dec) Topology of the selectivity filter of a TRPV channel: rapid accessibility of contiguous residues from the external medium. Am J Physiol Cell Physiol 293(6):C1962–C1970

    CAS  PubMed  Google Scholar 

  56. Voets T, Janssens A, Prenen J, Droogmans G, Nilius B (2003, Mar) Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol 121(3): 245–260

    PubMed Central  CAS  PubMed  Google Scholar 

  57. Bodding M, Wissenbach U, Flockerzi V (2002, Sep) The recombinant human TRPV6 channel functions as Ca2+ sensor in human embryonic kidney and rat basophilic leukemia cells. J Biol Chem 277(39):36656–36664

    CAS  PubMed  Google Scholar 

  58. Nilius B, Prenen J, Hoenderop JG, Vennekens R, Hoefs S, Weidema AF, Droogmans G, Bindels RJ (2002, Aug) Fast and slow inactivation kinetics of the Ca2+ channels ECaC1 and ECaC2 (TRPV5 and TRPV6). Role of the intracellular loop located between transmembrane segments 2 and 3. J Biol Chem 277(34):30852–30858

    CAS  PubMed  Google Scholar 

  59. Niemeyer BA, Bergs C, Wissenbach U, Flockerzi V, Trost C (2001, Mar) Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin. Proc Natl Acad Sci USA 98(6):3600–3605

    PubMed Central  CAS  PubMed  Google Scholar 

  60. Derler I, Hofbauer M, Kahr H, Fritsch R, Muik M, Kepplinger K, Hack ME, Moritz S, Schindl R, Groschner K, Romanin C (2006, Nov) Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation. J Physiol 577(Pt 1):31–44

    PubMed Central  CAS  PubMed  Google Scholar 

  61. Lambers TT, Weidema AF, Nilius B, Hoenderop JG, Bindels RJ (2004, July) Regulation of the mouse epithelial Ca2+ channel TRPV6 by the Ca2+-sensor calmodulin. J Biol Chem 279(28):28855–28861

    CAS  PubMed  Google Scholar 

  62. Lambers TT, Mahieu F, Oancea E, Hoofd L, de LF, Mensenkamp AR, Voets T, Nilius B, Clapham DE, Hoenderop JG, Bindels RJ (2006, July) Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport. EMBO J 25(13):2978–2988

    PubMed Central  CAS  PubMed  Google Scholar 

  63. Gkika D, Mahieu F, Nilius B, Hoenderop JG, Bindels. RJ (2004, June) 80 K-H as a new Ca2+ sensor regulating the activity of the epithelial Ca2+ channel transient receptor potential cation channel V5 (TRPV5). J Biol Chem 279(25):26351–26357

    CAS  PubMed  Google Scholar 

  64. Thyagarajan B, Benn BS, Christakos S, Rohacs T (2009, Mar) Phospholipase C-mediated regulation of transient receptor potential vanilloid 6 channels: implications in active intestinal Ca2+ transport. Mol Pharmacol 75(3):608–616

    PubMed Central  CAS  PubMed  Google Scholar 

  65. Thyagarajan B, Lukacs V, Rohacs T (2008, May) Hydrolysis of phosphatidylinositol 4,5-bisphosphate mediates calcium-induced inactivation of TRPV6 channels. J Biol Chem 283(22):14980–14987

    PubMed Central  CAS  PubMed  Google Scholar 

  66. Rohacs T, Nilius B (2007, Oct) Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch 455(1):157–168

    CAS  PubMed  Google Scholar 

  67. Lee J, Cha SK, Sun TJ, Huang CL (2005, Nov) PIP2 activates TRPV5 and releases its inhibition by intracellular Mg2+ . J Gen Physiol 126(5):439–451

    PubMed Central  CAS  PubMed  Google Scholar 

  68. Al-Ansary D, Bogeski I, Disteldorf BM, Becherer U, Niemeyer BA (2010, Feb) ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation. FASEB J 24(2):425–435

    CAS  PubMed  Google Scholar 

  69. Bonny O, Rubin A, Huang CL, Frawley WH, Pak CY, Moe OW (2008, Aug) Mechanism of urinary calcium regulation by urinary magnesium and pH. J Am Soc Nephrol 19(8): 1530–1537

    PubMed Central  CAS  PubMed  Google Scholar 

  70. Yeh BI, Yoon J, Huang CL (2006) On the role of pore helix in regulation of TRPV5 by extracellular protons. J Membr Biol 212(3):191–198

    CAS  PubMed  Google Scholar 

  71. Yeh BI, Kim YK, Jabbar W, Huang CL (2005, Sep) Conformational changes of pore helix coupled to gating of TRPV5 by protons. EMBO J 24(18):3224–3234

    PubMed Central  CAS  PubMed  Google Scholar 

  72. Yeh BI, Sun TJ, Lee JZ, Chen HH, Huang CL (2003, Dec) Mechanism and molecular determinant for regulation of rabbit transient receptor potential type 5 (TRPV5) channel by extracellular pH. J Biol Chem 278(51):51044–51052

    CAS  PubMed  Google Scholar 

  73. Cha SK, Jabbar W, Xie J, Huang CL (2007, Dec) Regulation of TRPV5 single-channel activity by intracellular pH. J Membr Biol 220(1–3):79–85

    CAS  PubMed  Google Scholar 

  74. Lambers TT, Oancea E, de GT, Topala CN, Hoenderop JG, Bindels RJ (2007, Feb) Extracellular pH dynamically controls cell surface delivery of functional TRPV5 channels. Mol Cell Biol 27(4):1486–1494

    PubMed Central  CAS  PubMed  Google Scholar 

  75. Gkika D, Topala CN, Chang Q, Picard N, Thebault S, Houillier P, Hoenderop JG, Bindels RJ (2006, Oct) Tissue kallikrein stimulates Ca2+ reabsorption via PKC-dependent plasma membrane accumulation of TRPV5. EMBO J 25(20):4707–4716

    PubMed Central  CAS  PubMed  Google Scholar 

  76. Wood RJ, Tchack L, Taparia S (2001) 1,25-Dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line. BMC Physiol 1:11

    PubMed Central  CAS  PubMed  Google Scholar 

  77. Hoenderop JG, Muller D, van der Kemp AW, Hartog A, Suzuki M, Ishibashi K, Imai M, Sweep F, Willems PH, van Os CH, Bindels RJ (2001, July) Calcitriol controls the epithelial calcium channel in kidney. J Am Soc Nephrol 12(7):1342–1349

    CAS  PubMed  Google Scholar 

  78. Walters JR, Barley NF, Khanji M, Rhodes-Kendler O (2004, May) Duodenal expression of the epithelial calcium transporter gene TRPV6: is there evidence for Vitamin D-dependence in humans? J Steroid Biochem Mol Biol 89–90(1–5):317–319

    PubMed  Google Scholar 

  79. Walters JR, Balesaria S, Chavele KM, Taylor V, Berry JL, Khair U, Barley NF, van Heel DA, Field J, Hayat JO, Bhattacharjee A, Jeffery R, Poulsom R (2006, Nov) Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. J Bone Miner Res 21(11):1770–1777

    CAS  PubMed  Google Scholar 

  80. Walters JR, Balesaria S, Khair U, Sangha S, Banks L, Berry JL (2007, Mar) The effects of Vitamin D metabolites on expression of genes for calcium transporters in human duodenum. J Steroid Biochem Mol Biol 103(3–5):509–512

    CAS  PubMed  Google Scholar 

  81. Balesaria S, Sangha S, Walters JR (2009, Dec) Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption. Am J Physiol Gastrointest Liver Physiol 297(6):G1193–G1197

    PubMed Central  CAS  PubMed  Google Scholar 

  82. Taparia S, Fleet JC, Peng JB, Wang XD, Wood RJ (2006, June) 1,25-Dihydroxyvitamin D and 25-hydroxyvitamin D–mediated regulation of TRPV6 (a putative epithelial calcium channel) mRNA expression in Caco-2 cells. Eur J Nutr 45(4):196–204

    CAS  PubMed  Google Scholar 

  83. Meyer MB, Watanuki M, Kim S, Shevde NK, Pike JW (2006, June) The human transient receptor potential vanilloid type 6 distal promoter contains multiple vitamin D receptor binding sites that mediate activation by 1,25-dihydroxyvitamin D3 in intestinal cells. Mol Endocrinol 20(6):1447–1461

    CAS  PubMed  Google Scholar 

  84. Meyer MB, Zella LA, Nerenz RD, Pike JW (2007, Aug) Characterizing early events associated with the activation of target genes by 1,25-dihydroxyvitamin D3 in mouse kidney and intestine in vivo. J Biol Chem 282(31):22344–22352

    CAS  PubMed  Google Scholar 

  85. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, Bourdeau V, Konstorum A, Lallemant B, Zhang R, Mader S, White JH (2005, Nov) Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 19(11):2685–2695

    CAS  PubMed  Google Scholar 

  86. Pike JW, Zella LA, Meyer MB, Fretz JA, Kim S (2007, Dec) Molecular actions of 1,25-dihydroxyvitamin D3 on genes involved in calcium homeostasis. J Bone Miner Res 22(Suppl 2):V16–V19

    CAS  PubMed  Google Scholar 

  87. Khanal RC, Peters TM, Smith NM, Nemere I (2008, Nov) Membrane receptor-initiated signaling in 1,25(OH)2D3-stimulated calcium uptake in intestinal epithelial cells. J Cell Biochem 105(4):1109–1116

    CAS  PubMed  Google Scholar 

  88. van AM, Hoenderop JG, van der Kemp AW, Friedlaender MM, van Leeuwen JP, Bindels RJ (2005, Oct) Coordinated control of renal Ca2+ transport proteins by parathyroid hormone. Kidney Int 68(4):1708–1721

    Google Scholar 

  89. Bacskai BJ, Friedman. PA (1990, Sep) Activation of latent Ca2+ channels in renal epithelial cells by parathyroid hormone. Nature 347(6291):388–391

    CAS  PubMed  Google Scholar 

  90. Friedman PA, Coutermarsh BA, Kennedy SM, Gesek FA (1996, Jan) Parathyroid hormone stimulation of calcium transport is mediated by dual signaling mechanisms involving protein kinase A and protein kinase C. Endocrinology 137(1):13–20

    CAS  PubMed  Google Scholar 

  91. de GT, Lee K, Langeslag M, Xi Q, Jalink K, Bindels RJ, Hoenderop JG (2009, Aug) Parathyroid hormone activates TRPV5 via PKA-dependent phosphorylation. J Am Soc Nephrol 20(8):1693–1704

    Google Scholar 

  92. Cha SK, Wu T, Huang CL (2008, May) Protein kinase C inhibits caveolae-mediated endocytosis of TRPV5. Am J Physiol Renal Physiol 294(5):F1212–F1221

    CAS  PubMed  Google Scholar 

  93. Elalouf JM, Roinel N, de RC (1984, Feb) ADH-like effects of calcitonin on electrolyte transport by Henle’s loop of rat kidney. Am J Physiol 246(2 Pt 2):F213–F220

    CAS  PubMed  Google Scholar 

  94. Di SA, Wittner M, Nitschke R, Braitsch R, Greger R, Bailly C, Amiel C, Roinel N, de RC (1990, Oct) Effects of parathyroid hormone and calcitonin on Na+, Cl-, K+, Mg2+ and Ca2+ transport in cortical and medullary thick ascending limbs of mouse kidney. Pflugers Arch 417(2):161–167

    Google Scholar 

  95. Hsu YJ, Dimke H, Hoenderop JG, Bindels RJ (2010, May) Calcitonin-stimulated renal Ca2+ reabsorption occurs independently of TRPV5. Nephrol Dial Transplant 25(5):1428–1435

    CAS  PubMed  Google Scholar 

  96. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997, Nov) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390(6655):45–51

    CAS  PubMed  Google Scholar 

  97. Kuro-o M (2010, Jan) Klotho. Pflugers Arch 459(2):333–343

    CAS  PubMed  Google Scholar 

  98. Chang Q, Hoefs S, van der Kemp AW, Topala CN, Bindels RJ, Hoenderop JG (2005, Oct) The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science 310(5747):490–493

    CAS  PubMed  Google Scholar 

  99. Lu P, Boros S, Chang Q, Bindels RJ, Hoenderop JG (2008, Nov) The beta-glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6. Nephrol Dial Transplant 23(11):3397–3402

    CAS  PubMed  Google Scholar 

  100. Cha SK, Ortega B, Kurosu H, Rosenblatt KP, Kuro O, Huang CL (2008, July) Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci USA 105(28):9805–9810

    PubMed Central  CAS  PubMed  Google Scholar 

  101. Cha SK, Hu MC, Kurosu H, Kuro-o M, Moe O, Huang CL (2009, July) Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol 76(1):38–46

    PubMed Central  CAS  PubMed  Google Scholar 

  102. Tohyama O, Imura A, Iwano A, Freund JN, Henrissat B, Fujimori T, Nabeshima Y (2004, Mar) Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem 279(11):9777–9784

    CAS  PubMed  Google Scholar 

  103. Tsuruoka S, Nishiki K, Ioka T, Ando H, Saito Y, Kurabayashi M, Nagai R, Fujimura A (2006, Oct) Defect in parathyroid-hormone-induced luminal calcium absorption in connecting tubules of Klotho mice. Nephrol Dial Transplant 21(10):2762–2767

    CAS  PubMed  Google Scholar 

  104. Brown AJ, Krits I, Armbrecht HJ (2005, May) Effect of age, vitamin D, and calcium on the regulation of rat intestinal epithelial calcium channels. Arch Biochem Biophys 437(1):51–58

    CAS  PubMed  Google Scholar 

  105. Song Y, Kato S, Fleet JC (2003, Feb) Vitamin D receptor (VDR) knockout mice reveal VDR-independent regulation of intestinal calcium absorption and ECaC2 and calbindin D9k mRNA. J Nutr 133(2):374–380

    CAS  PubMed  Google Scholar 

  106. Van Cromphaut SJ, Rummens K, Stockmans I, Van HE, Dijcks FA, Ederveen AG, Carmeliet P, Verhaeghe J, Bouillon R, Carmeliet G (2003, Oct) Intestinal calcium transporter genes are upregulated by estrogens and the reproductive cycle through vitamin D receptor-independent mechanisms. J Bone Miner Res 18(10):1725–1736

    PubMed  Google Scholar 

  107. Fudge NJ, Kovacs CS (2010, Mar) Pregnancy up-regulates intestinal calcium absorption and skeletal mineralization independently of the vitamin D receptor. Endocrinology 151(3): 886–895

    CAS  PubMed  Google Scholar 

  108. Charoenphandhu N, Nakkrasae LI, Kraidith K, Teerapornpuntakit J, Thongchote K, Thongon N, Krishnamra N (2009, Sep) Two-step stimulation of intestinal Ca2+ absorption during lactation by long-term prolactin exposure and suckling-induced prolactin surge. Am J Physiol Endocrinol Metab 297(3):E609–E619

    CAS  PubMed  Google Scholar 

  109. Song Y, Fleet JC (2004, Aug) 1,25 dihydroxycholecalciferol-mediated calcium absorption and gene expression are higher in female than in male mice. J Nutr 134(8):1857–1861

    CAS  PubMed  Google Scholar 

  110. van AM, Hoenderop JG, Dardenne O, St Arnaud R, van Os CH, Van Leeuwen HJ, Bindels RJ (2002, Aug) 1,25-dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney. J Am Soc Nephrol 13(8):2102–2109

    Google Scholar 

  111. Oz OK, Hajibeigi A, Howard K, Cummins CL, van AM, Bindels RJ, Word RA, Kuro-o M, Pak CY, Zerwekh JE (2007, Dec) Aromatase deficiency causes altered expression of molecules critical for calcium reabsorption in the kidneys of female mice *. J Bone Miner Res 22(12):1893–1902

    CAS  PubMed  Google Scholar 

  112. Irnaten M, Blanchard-Gutton N, Harvey BJ (2008, Nov) Rapid effects of 17beta-estradiol on epithelial TRPV6 Ca2+ channel in human T84 colonic cells. Cell Calcium 44(5): 441–452

    CAS  PubMed  Google Scholar 

  113. Irnaten M, Blanchard-Gutton N, Praetorius J, Harvey BJ (2009, Aug) Rapid effects of 17beta-estradiol on TRPV5 epithelial Ca2+ channels in rat renal cells. Steroids 74(8): 642–649

    CAS  PubMed  Google Scholar 

  114. Peng JB, Zhuang L, Berger UV, Adam RM, Williams BJ, Brown EM, Hediger MA, Freeman MR (2001, Apr) CaT1 expression correlates with tumor grade in prostate cancer. Biochem Biophys Res Commun 282(3):729–734

    CAS  PubMed  Google Scholar 

  115. Hsu YJ, Dimke H, Schoeber JP, Hsu SC, Lin SH, Chu P, Hoenderop JG, Bindels RJ (2010, Apr) Testosterone increases urinary calcium excretion and inhibits expression of renal calcium transport proteins. Kidney Int 77(7):601–608

    CAS  PubMed  Google Scholar 

  116. Teerapornpuntakit J, Dorkkam N, Wongdee K, Krishnamra N, Charoenphandhu N (2009, Apr) Endurance swimming stimulates transepithelial calcium transport and alters the expression of genes related to calcium absorption in the intestine of rats. Am J Physiol Endocrinol Metab 296(4):E775–E786

    CAS  PubMed  Google Scholar 

  117. Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Nikawa T, Arai H, Morita K, Taketani Y, Takeda E (2006) Immobilization decreases duodenal calcium absorption through a 1,25-dihydroxyvitamin D-dependent pathway. J. Bone Miner Metab 24(4):291–299

    CAS  PubMed  Google Scholar 

  118. van AM, Huybers S, Hoenderop JG, van der Kemp AW, van Leeuwen, JP, Bindels RJ (2006, Dec) Age-dependent alterations in Ca2+ homeostasis: role of TRPV5 and TRPV6. Am J Physiol Renal Physiol 291(6):F1177–F1183

    Google Scholar 

  119. Fukushima A, Aizaki Y, Sakuma K (2009, Jan) Short-chain fatty acids induce intestinal transient receptor potential vanilloid type 6 expression in rats and Caco-2 cells. J Nutr 139(1):20–25

    CAS  PubMed  Google Scholar 

  120. Fukushima A, Ohta A, Sakai K, Sakuma K (2005, Dec) Expression of calbindin-D9k, VDR and Cdx-2 messenger RNA in the process by which fructooligosaccharides increase calcium absorption in rats. J Nutr Sci Vitaminol (Tokyo) 51(6):426–432

    CAS  Google Scholar 

  121. Bianco SD, Peng JB, Takanaga H, Suzuki Y, Crescenzi A, Kos CH, Zhuang L, Freeman MR, Gouveia CH, Wu J, Luo H, Mauro T, Brown EM, Hediger MA (2007, Feb) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 22(2):274–285

    CAS  PubMed  Google Scholar 

  122. Hoenderop JG, van Leeuwen JP, van der Eerden BC, Kersten FF, van der Kemp AW, Merillat AM, Waarsing JH, Rossier BC, Vallon V, Hummler E, Bindels RJ (2003, Dec) Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 112(12):1906–1914

    PubMed Central  CAS  PubMed  Google Scholar 

  123. Benn BS, Ajibade D, Porta A, Dhawan P, Hediger M, Peng JB, Jiang Y, Oh GT, Jeung EB, Lieben L, Bouillon R, Carmeliet G, Christakos S (2008, June) Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology 149(6):3196–3205

    PubMed Central  CAS  PubMed  Google Scholar 

  124. Kutuzova GD, Sundersingh F, Vaughan J, Tadi BP, Ansay SE, Christakos S, Deluca HF (2008, Dec) TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo. Proc Natl Acad Sci USA 105(50):19655–19659

    PubMed Central  CAS  PubMed  Google Scholar 

  125. Bronner F (2009, Feb) Recent developments in intestinal calcium absorption. Nutr Rev 67(2):109–113

    PubMed  Google Scholar 

  126. Renkema KY, Nijenhuis T, van der Eerden BC, van der Kemp AW, Weinans H, van Leeuwen JP, Bindels RJ, Hoenderop JG (2005, Nov) Hypervitaminosis D mediates compensatory Ca2+ hyperabsorption in TRPV5 knockout mice. J Am Soc Nephrol 16(11): 3188–3195

    CAS  PubMed  Google Scholar 

  127. Renkema KY, Velic A, Dijkman HB, Verkaart S, van der Kemp AW, Nowik M, Timmermans K, Doucet A, Wagner CA, Bindels RJ, Hoenderop JG (2009, Aug) The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis. J Am Soc Nephrol 20(8):1705–1713

    PubMed Central  CAS  PubMed  Google Scholar 

  128. Nijenhuis T, van der Eerden BC, Hoenderop JG, Weinans H, van Leeuwen JP, Bindels. RJ (2008, Nov) Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5–/–mice. J Bone Miner Res 23(11):1815–1824

    CAS  PubMed  Google Scholar 

  129. Lieben L, Benn BS, Ajibade D, Stockmans I, Moermans K, Hediger MA, Peng JB, Christakos S, Bouillon R, Carmeliet G (2010, Aug) Trpv6 mediates intestinal calcium absorption during calcium restriction and contributes to bone homeostasis. Bone 47(2):301–308

    PubMed Central  CAS  PubMed  Google Scholar 

  130. Bernucci L, Henriquez M, Diaz P, Riquelme. G (2006, Nov) Diverse calcium channel types are present in the human placental syncytiotrophoblast basal membrane. Placenta 27 (11–12):1082–1095

    CAS  PubMed  Google Scholar 

  131. Moreau R, Hamel A, Daoud G, Simoneau L, Lafond J (2002, Nov) Expression of calcium channels along the differentiation of cultured trophoblast cells from human term placenta. Biol Reprod 67(5):1473–1479

    CAS  PubMed  Google Scholar 

  132. Moreau R, Daoud G, Bernatchez R, Simoneau L, Masse A, Lafond J (2002, Aug) Calcium uptake and calcium transporter expression by trophoblast cells from human term placenta. Biochim Biophys Acta 1564(2):325–332

    CAS  PubMed  Google Scholar 

  133. Stumpf T, Zhang Q, Hirnet D, Lewandrowski U, Sickmann A, Wissenbach U, Dorr J, Lohr C, Deitmer JW, Fecher-Trost C (2008, June) The human TRPV6 channel protein is associated with cyclophilin B in human placenta. J Biol Chem 283(26):18086–18098

    CAS  PubMed  Google Scholar 

  134. Suzuki Y, Kovacs CS, Takanaga H, Peng JB, Landowski CP, Hediger MA (2008, Aug) Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. J Bone Miner Res 23(8):1249–1256

    PubMed Central  CAS  PubMed  Google Scholar 

  135. Hache S, Takser L, Lebellego F, Weiler H, Leduc L, Forest JC, Giguere Y, Masse A, Barbeau B, Lafond J (2010, Feb) Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta. J Cell Mol Med [Epub ahead of print]

    Google Scholar 

  136. Lee GS, Jeung EB (2007, July) Uterine TRPV6 expression during the estrous cycle and pregnancy in a mouse model. Am J Physiol Endocrinol Metab 293(1):E132–E138

    CAS  PubMed  Google Scholar 

  137. Lee BM, Lee GS, Jung EM, Choi KC, Jeung EB (2009) Uterine and placental expression of TRPV6 gene is regulated via progesterone receptor- or estrogen receptor-mediated pathways during pregnancy in rodents. Reprod Biol Endocrinol 7:49

    PubMed Central  PubMed  Google Scholar 

  138. Kim HJ, Lee GS, Ji YK, Choi KC, Jeung EB (2006, Aug) Differential expression of uterine calcium transporter 1 and plasma membrane Ca2+ ATPase 1b during rat estrous cycle. Am J Physiol Endocrinol Metab 291(2):E234–E241

    CAS  PubMed  Google Scholar 

  139. Choi Y, Seo H, Kim M, Ka H (2009, Dec) Dynamic expression of calcium-regulatory molecules, TRPV6 and S100G, in the uterine endometrium during pregnancy in pigs. Biol Reprod 81(6):1122–1130

    CAS  PubMed  Google Scholar 

  140. van der Eerden BC, Hoenderop JG, de Vries TJ, Schoenmaker T, Buurman CJ, Uitterlinden AG, Pols HA, Bindels RJ, van Leeuwen JP (2005, Nov) The epithelial Ca2+ channel TRPV5 is essential for proper osteoclastic bone resorption. Proc Natl Acad Sci USA 102(48):17507–17512

    PubMed Central  PubMed  Google Scholar 

  141. Yamauchi D, Nakaya K, Raveendran NN, Harbidge DG, Singh R, Wangemann P, Marcus DC (2010) Expression of epithelial calcium transport system in rat cochlea and vestibular labyrinth. BMC Physiol 10:1

    PubMed Central  PubMed  Google Scholar 

  142. Wangemann P, Nakaya K, Wu T, Maganti RJ, Itza EM, Sanneman JD, Harbidge DG, Billings S, Marcus DC (2007, May) Loss of cochlear. Am J Physiol Renal Physiol 292(5): F1345–F1353

    PubMed Central  CAS  PubMed  Google Scholar 

  143. Nakaya K, Harbidge DG, Wangemann P, Schultz BD, Green ED, Wall SM, Marcus DC (May 2007) Lack of pendrin. Am J Physiol Renal Physiol 292(5):F1314–F1321

    PubMed Central  CAS  PubMed  Google Scholar 

  144. Yamauchi D, Raveendran NN, Pondugula SR, Kampalli SB, Sanneman JD, Harbidge DG, Marcus DC (2005, June) Vitamin D upregulates expression of ECaC1 mRNA in semicircular canal. Biochem Biophys Res Commun 331(4):1353–1357

    CAS  PubMed  Google Scholar 

  145. Takumida M, Ishibashi T, Hamamoto T, Hirakawa K, Anniko M (February 2009) Age-dependent changes in the expression of klotho protein, TRPV5 and TRPV6 in mouse inner ear. Acta Otolaryngol 25:1–11

    Google Scholar 

  146. Homann V, Kinne-Saffran E, Arnold WH, Gaengler P, Kinne RK (May 2006) Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva. Histochem Cell Biol 125(5):583–591

    CAS  PubMed  Google Scholar 

  147. Lehen’kyi V, Beck B, Polakowska R, Charveron M, Bordat P, Skryma R, Prevarskaya N (2007, Aug) TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes. J Biol Chem 282(31):22582–22591

    PubMed  Google Scholar 

  148. Kennedy BG, Torabi AJ, Kurzawa R, Echtenkamp SF, Mangini NJ (2010) Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium. Mol Vis 16:665–675

    PubMed Central  CAS  PubMed  Google Scholar 

  149. Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H (2003, Oct) Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22(49):7858–7861

    CAS  PubMed  Google Scholar 

  150. Vanden Abeele F, Lemonnier L, Thebault S, Lepage G, Parys JB, Shuba Y, Skryma R, Prevarskaya N (2004, July) Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells. J Biol Chem 279(29):30326–30337

    CAS  PubMed  Google Scholar 

  151. Vanden Abeele F, Roudbaraki M, Shuba Y, Skryma R, Prevarskaya N (2003, Apr) Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1. J Biol Chem 278(17):15381–15389

    CAS  PubMed  Google Scholar 

  152. Bodding M, Fecher-Trost C, Flockerzi V (2003, Dec) Store-operated Ca2+ current and TRPV6 channels in lymph node prostate cancer cells. J Biol Chem 278(51):50872–50879

    PubMed  Google Scholar 

  153. Pigozzi D, Ducret T, Tajeddine N, Gala JL, Tombal B, Gailly P (2006, May) Calcium store contents control the expression of TRPC1, TRPC3 and TRPV6 proteins in LNCaP prostate cancer cell line. Cell Calcium 39(5):401–415

    CAS  PubMed  Google Scholar 

  154. Lehen’kyi V, Flourakis M, Skryma R, Prevarskaya N (2007, Nov) TRPV6 channel controls prostate cancer cell proliferation via Ca2+/NFAT-dependent pathways. Oncogene 26(52):7380–7385

    PubMed  Google Scholar 

  155. Lallet-Daher H, Roudbaraki M, Bavencoffe A, Mariot P, Gackiere F, Bidaux G, Urbain R, Gosset P, Delcourt P, Fleurisse L, Slomianny C, Dewailly E, Mauroy B, Bonnal JL, Skryma R, Prevarskaya N (2009, Apr) Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry. Oncogene 28(15):1792–1806

    CAS  PubMed  Google Scholar 

  156. Bolanz KA, Hediger MA, Landowski CP (2008, Feb) The role of TRPV6 in breast carcinogenesis. Mol Cancer Ther 7(2):271–279

    CAS  PubMed  Google Scholar 

  157. Bolanz KA, Kovacs GG, Landowski CP, Hediger MA (2009, Dec) Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Mol Cancer Res 7(12):2000–2010

    CAS  PubMed  Google Scholar 

  158. Peleg S, Sellin JH, Wang Y, Freeman MR, Umar S (2010, Sep) Suppression of aberrant transient receptor potential cation channel, subfamily V, member 6 expression in hyperproliferative colonic crypts by dietary calcium. Am J Physiol Gastrointest Liver Physiol 299(3):G593–601

    PubMed Central  CAS  PubMed  Google Scholar 

  159. Chow J, Norng M, Zhang J, Chai J (2007, Apr) TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells–Mechanisms behind a possible new hot cancer treatment. Biochim Biophys Acta 1773(4):565–576

    CAS  PubMed  Google Scholar 

  160. Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP (2001, Aug) Human hypertension caused by mutations in WNK kinases. Science 293(5532):1107–1112

    CAS  PubMed  Google Scholar 

  161. Mayan H, Munter G, Shaharabany M, Mouallem M, Pauzner R, Holtzman EJ, Farfel Z (2004, Aug) Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. J Clin Endocrinol Metab 89(8):4025–4030

    CAS  PubMed  Google Scholar 

  162. Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z (2002, July) Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab 87(7):3248–3254

    CAS  PubMed  Google Scholar 

  163. Jiang Y, Ferguson WB, Peng JB (2007, Feb) WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. Am J Physiol Renal Physiol 292(2):F545–F554

    CAS  PubMed  Google Scholar 

  164. Zhang W, Na T, Peng JB (2008, Nov) WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway. Am J Physiol Renal Physiol 295(5):F1472–F1484

    PubMed Central  CAS  PubMed  Google Scholar 

  165. Jiang Y, Cong P, Williams SR, Zhang W, Na T, Ma HP, Peng JB (2008, Oct) WNK4 regulates the secretory pathway via which TRPV5 is targeted to the plasma membrane. Biochem Biophys Res Commun 375(2):225–229

    PubMed Central  CAS  PubMed  Google Scholar 

  166. Yang CL, Angell J, Mitchell R, Ellison DH (2003, Apr) WNK kinases regulate thiazide-sensitive Na-Cl cotransport. J Clin Invest 111(7):1039–1045

    PubMed Central  CAS  PubMed  Google Scholar 

  167. Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP (2003, Jan) Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4. Proc Natl Acad Sci USA 100(2):680–684

    PubMed Central  CAS  PubMed  Google Scholar 

  168. Yang SS, Hsu YJ, Chiga M, Rai T, Sasaki S, Uchida S, Lin SH (2010, Apr) Mechanisms for Hypercalciuria in Pseudohypoaldosteronism Type II-Causing WNK4 Knock-In Mice. Endocrinology 151(4):1829–1836

    CAS  PubMed  Google Scholar 

  169. O’Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW (2006, Sep) Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo. J Am Soc Nephrol 17(9):2402–2413

    PubMed  Google Scholar 

  170. Kim MH, Lee GS, Jung EM, Choi KC, Jeung EB (2009, July) The negative effect of dexamethasone on calcium-processing gene expressions is associated with a glucocorticoid-induced calcium-absorbing disorder. Life Sci 85(3–4):146–152

    CAS  PubMed  Google Scholar 

  171. Kim MH, Lee GS, Jung EM, Choi KC, Oh GT, Jeung EB (2009, Jan) Dexamethasone differentially regulates renal and duodenal calcium-processing genes in calbindin-D9k and -D28k knockout mice. Exp Physiol 94(1):138–151

    CAS  PubMed  Google Scholar 

  172. Huybers S, Naber TH, Bindels RJ, Hoenderop JG (2007, Jan) Prednisolone-induced Ca2+ malabsorption is caused by diminished expression of the epithelial Ca2+ channel TRPV6. Am J Physiol Gastrointest Liver Physiol 292(1):G92–G97

    CAS  PubMed  Google Scholar 

  173. Bohmer C, Palmada M, Kenngott C, Lindner R, Klaus F, Laufer J, Lang F (2007, Dec) Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3. FEBS Lett 581(29):5586–5590

    CAS  PubMed  Google Scholar 

  174. Palmada M, Poppendieck S, Embark HM, van de Graaf SF, Boehmer C, Bindels RJ, Lang F (2005) Requirement of PDZ domains for the stimulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase SGK1. Cell Physiol Biochem 15(1–4):175–182

    CAS  PubMed  Google Scholar 

  175. Embark HM, Setiawan I, Poppendieck S, van de Graaf SF, Boehmer C, Palmada M, Wieder T, Gerstberger R, Cohen P, Yun CC, Bindels RJ, Lang F (2004) Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes. Cell Physiol Biochem 14(4–6):203–212

    CAS  PubMed  Google Scholar 

  176. Sopjani M, Kunert A, Czarkowski K, Klaus F, Laufer J, Foller M, Lang F (2010, Feb) Regulation of the Ca2+ channel TRPV6 by the kinases SGK1, PKB/Akt, and PIKfyve. J Membr Biol 233(1–3):35–41

    CAS  PubMed  Google Scholar 

  177. Sandulache D, Grahammer F, Artunc F, Henke G, Hussain A, Nasir O, Mack A, Friedrich B, Vallon V, Wulff P, Kuhl D, Palmada M, Lang F (2006, July) Renal Ca2+ handling in sgk1 knockout mice. Pflugers Arch 452(4):444–452

    CAS  PubMed  Google Scholar 

  178. Jang HR, Kim S, Heo NJ, Lee JH, Kim HS, Nielsen S, Jeon US, Oh YK, Na KY, Joo KW, Han JS (2009, Jan) Effects of thiazide on the expression of TRPV5, calbindin-D28K, and sodium transporters in hypercalciuric rats. J Korean Med Sci 24(Suppl):S161–S169

    PubMed Central  CAS  PubMed  Google Scholar 

  179. Nijenhuis T, Vallon V, van der Kemp AW, Loffing J, Hoenderop JG, Bindels RJ (2005, June) Enhanced passive Ca2+ reabsorption and reduced Mg2+ channel abundance explains thiazide-induced hypocalciuria and hypomagnesemia. J Clin Invest 115(6):1651–1658

    PubMed Central  CAS  PubMed  Google Scholar 

  180. Lee CT, Shang S, Lai LW, Yong KC, Lien YH (2004, Dec) Effect of thiazide on renal gene expression of apical calcium channels and calbindins. Am J Physiol Renal Physiol 287(6):F1164–F1170

    CAS  PubMed  Google Scholar 

  181. Nijenhuis T, Hoenderop JG, Loffing J, van der Kemp AW, van Os CH, Bindels RJ (2003, Aug) Thiazide-induced hypocalciuria is accompanied by a decreased expression of Ca2+ transport proteins in kidney. Kidney Int 64(2):555–564

    CAS  PubMed  Google Scholar 

  182. Friedman PA, Bushinsky DA (1999, Nov) Diuretic effects on calcium metabolism. Semin Nephrol 19(6):551–556

    CAS  PubMed  Google Scholar 

  183. Lee CT, Chen HC, Lai LW, Yong KC, Lien YH (2007, Oct) Effects of furosemide on renal calcium handling. Am J Physiol Renal Physiol 293(4):F1231–F1237

    CAS  PubMed  Google Scholar 

  184. Lee CT, Lien YH, Lai LW, Chen JB, Lin CR, Chen HC (2006, May) Increased renal calcium and magnesium transporter abundance in streptozotocin-induced diabetes mellitus. Kidney Int 69(10):1786–1791

    CAS  PubMed  Google Scholar 

  185. Hoenderop JG, Dardenne O, van AM, van der Kemp AW, van Os CH, St Arnaud R, Bindels RJ (2002, Sep) Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. FASEB J 16(11):1398–1406

    CAS  PubMed  Google Scholar 

  186. Ignat M, Teletin M, Tisserand J, Khetchoumian K, Dennefeld C, Chambon P, Losson R, Mark M (2008, Feb) Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha. Proc Natl Acad Sci USA 105(7):2598–2603

    PubMed Central  CAS  PubMed  Google Scholar 

  187. Huybers S, Apostolaki M, van der Eerden BC, Kollias G, Naber TH, Bindels RJ, Hoenderop JG (2008, June) Murine TNF(DeltaARE) Crohn’s disease model displays diminished expression of intestinal Ca2+ transporters. Inflamm Bowel Dis 14(6):803–811

    PubMed  Google Scholar 

  188. Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Gunzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Muller D (2010, Feb) Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol [Epub ahead of print]

    Google Scholar 

  189. Nijenhuis T, Hoenderop JG, Bindels RJ (2004, Mar) Downregulation of Ca2+ and Mg2+ transport proteins in the kidney explains tacrolimus (FK506)-induced hypercalciuria and hypomagnesemia. J Am Soc Nephrol 15(3):549–557

    CAS  PubMed  Google Scholar 

  190. Lee GS, Byun HS, Kim MH, Lee BM, Ko SH, Jung EM, Gwak KS, Choi IG, Kang HY, Jo HJ, Lee HJ, Jeung EB (2008, Nov) The beneficial effect of the sap of Acer mono in an animal with low-calcium diet-induced osteoporosis-like symptoms. Br J Nutr 100(5):1011–1018

    CAS  PubMed  Google Scholar 

  191. Akey JM, Eberle MA, Rieder MJ, Carlson CS, Shriver MD, Nickerson DA, Kruglyak L (2004, Oct) Population history and natural selection shape patterns of genetic variation in 132 genes. PLoS Biol 2(10):e286

    PubMed Central  PubMed  Google Scholar 

  192. Stajich JE, Hahn MW (2005, Jan) Disentangling the effects of demography and selection in human history. Mol Biol Evol 22(1):63–73

    CAS  PubMed  Google Scholar 

  193. Hughes DA, Tang K, Strotmann R, Schoneberg T, Prenen J, Nilius B, Stoneking M (2008) Parallel selection on TRPV6 in human populations. PLoS One 3(2):e1686

    PubMed Central  PubMed  Google Scholar 

  194. Soejima M, Tachida H, Koda Y (2009, Feb) Sequence analysis of human TRPV6 suggests positive selection outside Africa. Biochem Genet 47(1–2):147–153

    CAS  PubMed  Google Scholar 

  195. Akey JM, Swanson WJ, Madeoy J, Eberle M, Shriver MD (2006, July) TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations. Hum Mol Genet 15(13):2106–2113

    CAS  PubMed  Google Scholar 

  196. Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN (2004, June) Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 74(6):1111–1120

    PubMed Central  CAS  PubMed  Google Scholar 

  197. Holick MF, MacLaughlin JA, Doppelt SH (1981, Feb) Regulation of cutaneous previtamin D3 photosynthesis in man: skin pigment is not an essential regulator. Science 211(4482):590–593

    CAS  PubMed  Google Scholar 

  198. Braun M, Palacios C, Wigertz K, Jackman LA, Bryant RJ, McCabe LD, Martin BR, McCabe GP, Peacock M, Weaver CM (2007, June) Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakes. Am J Clin Nutr 85(6):1657–1663

    CAS  PubMed  Google Scholar 

  199. Suzuki Y, Pasch A, Bonny O, Mohaupt MG, Hediger MA, Frey FJ (2008, June) Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation. Hum Mol Genet 17(11):1613–1618

    CAS  PubMed  Google Scholar 

  200. Na T, Zhang W, Jiang Y, Liang Y, Ma HP, Warnock DG, Peng JB (2009, May) The A563T variation of the renal epithelial calcium channel TRPV5 among African Americans enhances calcium influx. Am J Physiol Renal Physiol 296(5):F1042–F1051

    PubMed Central  CAS  PubMed  Google Scholar 

  201. Pratt JH, Manatunga AK, Peacock M (1996, Jan) A comparison of the urinary excretion of bone resorptive products in white and black children. J Lab Clin Med 127(1):67–70

    CAS  PubMed  Google Scholar 

  202. Taylor EN, Curhan GC (2007, Feb) Differences in 24-hour urine composition between black and white women. J Am Soc Nephrol 18(2):654–659

    CAS  PubMed  Google Scholar 

  203. Sarmina I, Spirnak JP, Resnick MI (1987, July) Urinary lithiasis in the black population: an epidemiological study and review of the literature. J Urol 138(1):14–17

    CAS  PubMed  Google Scholar 

  204. Stamatelou KK, Francis ME, Jones CA, Nyberg LM, Curhan GC (2003, May) Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int 63(5):1817–1823

    PubMed  Google Scholar 

  205. Bell NH, Shary J, Stevens J, Garza M, Gordon L, Edwards J (1991, July) Demonstration that bone mass is greater in black than in white children. J Bone Miner Res 6(7):719–723

    CAS  PubMed  Google Scholar 

  206. Bohannon AD (1999, June) Osteoporosis and African American women. J Womens Health Gend Based Med 8(5):609–615

    CAS  PubMed  Google Scholar 

  207. Renkema KY, Lee K, Topala CN, Goossens M, Houillier P, Bindels RJ, Hoenderop JG (2009, June) TRPV5 gene polymorphisms in renal hypercalciuria. Nephrol Dial Transplant 24(6):1919–1924

    CAS  PubMed  Google Scholar 

  208. Muller D, Hoenderop JG, Vennekens R, Eggert P, Harangi F, Mehes K, Garcia-Nieto V, Claverie-Martin F, Os CH, Nilius B, Bindels JM (2002, Sep) Epithelial Ca2+ channel (ECAC1) in autosomal dominant idiopathic hypercalciuria. Nephrol Dial Transplant 17(9):1614–1620

    PubMed  Google Scholar 

  209. Burks DA, Littleton RH (1992) The epidemiology of prostate cancer in black men. Henry Ford Hosp Med J 40(1–2):89–92

    CAS  PubMed  Google Scholar 

  210. Powell IJ (1997, May) Prostate cancer and African–American men. Oncology (Williston Park) 11(5):599–605

    CAS  Google Scholar 

  211. Kessler T, Wissenbach U, Grobholz R, Flockerzi V (2009) TRPV6 alleles do not influence prostate cancer progression. BMC Cancer 9:380

    PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

I thank my colleagues Drs. Yi Jiang, Wei Zhang, Tao Na, Guojin Wu, and Haiyan Jing for their contributions to the research projects in our group and their participation in regular literature review. The research of our lab was supported by the National Institute of Diabetes and Digestive and Kidney Diseases (R01DK072154), and American Heart Association National Center (0430125 N) and Greater Southeast Affiliate (09GRNT2160024).

Author information

Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL, 35294, USA

    Ji -Bin Peng

Authors
  1. Ji -Bin Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ji -Bin Peng .

Editor information

Editors and Affiliations

  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Peng, J.B. (2011). TRPV5 and TRPV6 in Transcellular Ca2+ Transport: Regulation, Gene Duplication, and Polymorphisms in African Populations. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_14

Download citation

Publish with us

Policies and ethics

Search

Navigation