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Structural Biology of TRP Channels

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Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

Structural studies on TRP channels, while limited, are poised for a quickened pace and rapid expansion. As of yet, no high-resolution structure of a full length TRP channel exists, but low-resolution electron cryomicroscopy structures have been obtained for 4 TRP channels, and high-resolution NMR and X-ray crystal structures have been obtained for the cytoplasmic domains, including an atypical protein kinase domain, ankyrin repeats, coiled coil domains and a Ca2+-binding domain, of 6 TRP channels. These structures enhance our understanding of TRP channel assembly and regulation. Continued technical advances in structural approaches promise a bright outlook for TRP channel structural biology.

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Acknowledgments

We thank Kathryn Abele, Ioannis Michailidis and Zafir Buraei for reading and commenting on a draft of this chapter. This work was supported by National Institutes of Health grants NS045383 and GM085234 (to J.Y.).

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  1. Department of Biological Sciences, Columbia University, New York, NY, 10027, USA

    Minghui Li, Yong Yu & Jian Yang

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  1. Minghui Li
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Correspondence to Jian Yang .

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  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Li, M., Yu, Y., Yang, J. (2011). Structural Biology of TRP Channels. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_1

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