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Mechanosensitivity and Mechanotransduction pp 67–76Cite as

Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts

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Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 4))

Abstract

Mechanosensitivity is the ability of tissues and cells to detect and make response to mechanical stimuli. Osteoblast is a kind of important mechanosensitive cell in bone tissue, while cytoskeleton plays an important role in the mechanotransduction in osteoblasts. This article reviewed the roles of cytoskeleton on the mechanotransduction of genes in osteoblasts, summarized that cytoskeleton integrity is essential for the expression of bone formation–related genes in osteoblasts, and concluded that cytoskeleton reorganization inhibition can enhance the mechanosensitivity of some genes in osteoblasts. Further researches on the specific mechanisms of cytoskeleton will shed new light on the transmission mechanisms of mechanical stress in osteoblasts, and will lay the foundation for the further investigations on the biomechanical behaviors of bone cells and even bone tissues.

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Acknowledgments

This work was supported by the Science and Technology Projects of Guangdong Province (No. 2008B030301121 and 2009B050700027), China.

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Authors and Affiliations

  1. Department of Prosthodontics, Guanghua School & Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, 510055, Guangdong, China

    Qiang Fu

  2. Department of Prosthodontics, Guanghua School & Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, 510055, Guangdong, PR China

    Yiping Zhang, Yajuan Xu, Yourui Li, Ling Guo & Minfeng Shao

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  1. Qiang Fu
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  2. Yiping Zhang
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  3. Yajuan Xu
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  4. Yourui Li
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  5. Ling Guo
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  6. Minfeng Shao
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Correspondence to Qiang Fu .

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Editors and Affiliations

  1. Chemical Department, Moscow State University, Vorobiovy Gory MSU, Moscow, 119899, Russian Federation

    Andre Kamkin

  2. , Department of Fundamental and Applied Ph, Russian State Medical University, Ostrovitjanova Str. 1, Moscow, 117997, Russian Federation

    Irina Kiseleva

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Fu, Q., Zhang, Y., Xu, Y., Li, Y., Guo, L., Shao, M. (2010). Effect of Cytoskeleton on the Mechanosensitivity of Genes in Osteoblasts. In: Kamkin, A., Kiseleva, I. (eds) Mechanosensitivity and Mechanotransduction. Mechanosensitivity in Cells and Tissues, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9881-8_3

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