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Taxanes and Epothilones in Cancer Treatment

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Book cover Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures

Part of the book series: Cancer Growth and Progression ((CAGP,volume 13))

Abstract

The discovery of compounds that bind and inhibit the function of microtubules dates back many centuries. The first compound to be used medicinally in humans, ultimately identified to have anti-microtubule properties, was colchicine. Colchicine, extracted from the plant Colchicum autumnale, was first administered to humans with gout in the sixth century A.D. [1]. After it was identified that colchicine blocked cells in metaphase, the compound became an important tool in the study of the cell cycle and mitosis [2].

There is no subject so old that something new cannot be said about it.

Dostoyevsky, A Diary of a Writer (1876), 3, July–August

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  1. Melanoma Research Center, Pacific Oncology and Hematology Associates, San Diego, CA, USA

    Edward F. McClay

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    Boris R. Minev

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McClay, E.F. (2011). Taxanes and Epothilones in Cancer Treatment. In: Minev, B. (eds) Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Cancer Growth and Progression, vol 13. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9704-0_3

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