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Coupling Membrane Dynamics to Actin Polymerization

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Actin-based Motility

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Abstract

WASP/WAVE family proteins are important regulators of the Arp2/3 complex, which causes exponential growth of actin filaments. WASP/WAVE proteins mediate actin polymerization for both cellular protrusions, such as filopodia and lamellipodia, and invaginations, such as coated pits for endocytosis. However, it had been unclear how the direction of actin polymerization for these topologically different structures is precisely regulated. Recently, the BAR domain superfamily members, which contain membrane-deforming or membrane-adaptor domains, were found to interact with the WASP/WAVE family proteins. These membrane-deforming or membrane-adaptor domains contain BAR, EFC/F-BAR, and IMD/I-BAR domains, which induce membrane invaginations or membrane protrusions. Due to the various geometries of the membranes bound by the BAR domain superfamily members, these proteins could connect specific membrane structures to actin filaments, mediated by the WASP/WAVE family proteins and the Arp2/3 complex.

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Authors and Affiliations

  1. Laboratory of Membrane and Cytoskeleton Dynamics, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan

    Shiro Suetsugu

  2. PRESTO, Japan Science and Technology Agency, Saitama, Japan

    Shiro Suetsugu

  3. Department of Lipid Biochemistry, Kobe University Graduate School of Medicine, Kobe, Japan

    Tadaomi Takenawa

Authors
  1. Shiro Suetsugu
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  2. Tadaomi Takenawa
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Correspondence to Shiro Suetsugu .

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Editors and Affiliations

  1. , Laboratory of Structural Enzymology and, CNRS, Gif-sur-Yvette Cedex, 91198, France

    Marie-France Carlier

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Suetsugu, S., Takenawa, T. (2010). Coupling Membrane Dynamics to Actin Polymerization. In: Carlier, MF. (eds) Actin-based Motility. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9301-1_2

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