Chapter

Regenerative Medicine

pp 187-205

Date:

Induced Pluripotent Stem Cells

  • Kazutoshi TakahashiAffiliated withCenter for iPS cell Research and Application, Institute for Integrated Cell-Material Sciences, Kyoto University
  • , Shinya YamanakaAffiliated withCenter for iPS cell Research and Application, Institute for Integrated Cell-Material Sciences, Kyoto UniversityDepartment of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto UniversityYamanaka iPS Cell Special Project, Japan Science and Technology AgencyGladstone Institute of Cardiovascular Disease

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Abstract

Nearly 50 years have passed since the concept of nuclear ­reprogramming was proposed for the first time. Since then, several approaches have been developed to convert somatic cells to a pluripotent state. Direct reprogramming with defined factors, is the newest of these approaches. This method requires just a few genes, and it also has a great reproducibility. Applying this method to humans seems to open the door to cell transplantation therapy without immune rejection, drug ­discovery, and elucidation of the pathogenesis of intractable diseases. However, this concept still faces some issues which must be overcome before application due to a shortage of experience. This chapter introduces an overview of direct reprogramming as well as a special focus on its potentials and challenges.