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Calorie Restriction, Aging and Longevity pp 263–277Cite as

Caloric Restriction and Cardiovascular Disease

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Abstract

Cardiovascular disease is a main cause of morbidity and a leading cause of death of the elderly in Western societies. It is widely accepted that the dietary regimen known as caloric restriction, undernutrition without malnutrition, delays the onset of aging and extends lifespan in laboratory animal models. Evidence supporting the role of caloric restriction intervening in the cardiovascular aging process by preventing the development of cardiovascular disease is presented in detail in this review. The theme that emerges from this overview is that neuroendocrine factors induced by caloric restriction attenuate age-related reactive oxygen species (ROS) overproduction and prevent inflammatory phenotypic alterations in the cardiovascular system. Also discussed are some of the possible caloric restriction-induced cellular mechanisms by which age-related vascular oxidative stress and inflammation can be delayed or reversed thereby improving cardiovascular health in the elderly.

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Acknowledgments

This work was supported by grants from the American Diabetes Association (to ZU), the American Federation for Aging Research (to AC), the NIH (HL077256 and HL43023 to ZU and AC) and the Intramural Research Program of the National Institute on Aging, NIH (to RDC).

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Authors and Affiliations

  1. Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA

    Anna Csiszar & Zoltan Ungvari

  2. Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    Rafael de Cabo

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  1. Anna Csiszar
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  2. Rafael de Cabo
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  3. Zoltan Ungvari
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Editors and Affiliations

  1. Sydney, 2006, Australia

    Arthur V. Everitt

  2. University of Aarhus, University of Aarhus, Aarhus, 8000, Denmark

    Suresh I. S. Rattan

  3. Sydney, 2006, Australia

    David G. le Couteur

  4. National Institute on Aging, Gerontology Research Center, National Institute of Health, Nathan Shock Drive 5600, Baltimore, 21224, USA

    Rafael de Cabo

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Csiszar, A., de Cabo, R., Ungvari, Z. (2010). Caloric Restriction and Cardiovascular Disease. In: Everitt, A., Rattan, S., le Couteur, D., de Cabo, R. (eds) Calorie Restriction, Aging and Longevity. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8556-6_15

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