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The Aging Liver and the Effects of Long Term Caloric Restriction

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Calorie Restriction, Aging and Longevity

Abstract

The liver undergoes changes in structure and function in old age. There are age-related changes in liver mass, blood flow and hepatocyte and sinusoidal cell morphology. These changes are associated with significant impairment of many hepatic metabolic and detoxification activities. This has implications for systemic aging and age-related disease. For example the age-related impairment of the hepatic metabolism of lipoproteins predisposes to cardiovascular disease. The effects of caloric restriction in the liver are beneficial in terms of ameliorating many of deleterious phenotypic effects of ageing, but from the mechanistic point of view, caloric restriction does not just simply reverse or delay age-related cellular changes. Instead caloric restriction appears to act via discrete cellular mechanisms such as sirtuin pathways that impact cellular bioenergetics, apoptosis and other cellular functions. The liver has as a pivotal coordinating role when dietary intake is reduced, therefore many of the effects of caloric restriction are mediated by the liver.

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Acknowledgments

We acknowledge the support of the Australian National Health and Medical Research Council, Canadian Institutes of Health Research and the Ageing and Alzheimers Research Foundation (a division of the Medical Foundation of the University of Sydney). DAS is a consultant to GSK and Genocea, and research is supported by grants from the National Institutes of Health, The Ellison Medical Foundation, and the Glenn Foundation for Medical Research.

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Authors and Affiliations

  1. ANZAC Research Institute, Centre for Education and Research on Ageing, Concord RG Hospital, The University of Sydney, Sydney, Australia

    David G. Le Couteur, Victoria C. Cogger, Aisling C. McMahon, Alessandra Warren & Arthur V. Everitt

  2. Glenn Laboratories for Aging Research, Department of Pathology, Harvard Medical School, Boston, MA, USA

    David A. Sinclair

  3. Centre de Recherche en Cancérologie de l’Université Laval, Hôpital Hôtel-Dieu de Québec, Québec, Canada

    Michel Lebel

  4. Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA

    Rafael de Cabo

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  1. Sydney, 2006, Australia

    Arthur V. Everitt

  2. University of Aarhus, University of Aarhus, Aarhus, 8000, Denmark

    Suresh I. S. Rattan

  3. Sydney, 2006, Australia

    David G. le Couteur

  4. National Institute on Aging, Gerontology Research Center, National Institute of Health, Nathan Shock Drive 5600, Baltimore, 21224, USA

    Rafael de Cabo

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Le Couteur, D.G. et al. (2010). The Aging Liver and the Effects of Long Term Caloric Restriction. In: Everitt, A., Rattan, S., le Couteur, D., de Cabo, R. (eds) Calorie Restriction, Aging and Longevity. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8556-6_11

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