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Mechanisms of Cancer Growth and Progression in Lymphoma

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Mechanisms of Oncogenesis

Part of the book series: Cancer Growth and Progression ((CAGP,volume 12))

Abstract

B-cell lymphomas often recapitulate the stages of normal lymphocyte differentiation as shown by molecular techniques such as gene-expression profiling. This similarity is a major basis for B-cell lymphoma classification and nomenclature. B-cell development is a central component of the adaptive immune response. B-cell differentiation begins as progenitor B-cells undergo immunoglobulin gene rearrangement and differentiate into naive B-cells that express surface immunoglobulin molecule. Upon antigen encounter, naïve B-cells undergo transformation and ultimately differentiation into memory B cells or antibody secreting plasma cells, primarily through germinal centers of the secondary lymphoid tissue. These developmental stages are influenced by extrinsic signals, interaction with cellular elements and microenvironment, and controlled by transcriptional regulation. Aberrations during B-cell development, activation and differentiation, particularly during the germinal centre (GC) reaction, can lead to oncogenic chromosomal translocations that block differentiation, prevent apoptosis or promote proliferation. Unregulated extrinsic signals including cytokines and antigenic stimulation can further contribute to progression of malignant transformation.

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Authors and Affiliations

  1. Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, FL, USA

    Mojdeh Naghashpour

  2. Department of Oncologic Sciences, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA

    Lynn C. Moscinski

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  1. Mojdeh Naghashpour
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Correspondence to Mojdeh Naghashpour .

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  1. Research Institute, H. Lee Moffitt Cancer Center &, Magnolia Drive 12902, Tampa, 33612, USA

    Domenico Coppola

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Naghashpour, M., Moscinski, L.C. (2010). Mechanisms of Cancer Growth and Progression in Lymphoma. In: Coppola, D. (eds) Mechanisms of Oncogenesis. Cancer Growth and Progression, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3725-1_7

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