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Stimulation of Wound Revascularization by Adenosine Receptor Activation

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Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function

Abstract

Adenosine is an endogenous mediator implicated in wound healing. The exact mechanisms and receptors involved are still under evaluation. We have observed that topical application of a selective adenosine A2A receptor agonist promotes wound healing in experimental animals, both healthy and with impaired healing. Histological analysis revealed that adenosine promoted granulation tissue formation, with increased cellularity, matrix deposition, and vessel density. Adenosine may exert effects on many different cell types that finally result in promotion of angiogenesis and, furthermore, homing of endothelial precursor cells into sites of injury. We will review the effect of adenosine receptor activation on microvascular endothelial cell function and on wound revascularization.

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Authors and Affiliations

  1. Department de Farmacologia, Universitat de València, Ave. Vicent Andrès Estellès s/n, 46100, Burjassot, Valencia, Spain

    M. Carmen Montesinos & María D. Valls

  2. Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Valencia, Spain

    M. Carmen Montesinos

  3. Department of Medicine, New York University School of Medicine, 550 First Ave, New York, NY, 10016, USA

    M. Carmen Montesinos

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  1. M. Carmen Montesinos
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  2. María D. Valls
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Correspondence to M. Carmen Montesinos .

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Editors and Affiliations

  1. Dept. Pediatrics, Pediatric Clinical Services, University of Colorado, Denver, East 19th Avenue 12700, Aurora, 80045, USA

    Evgenia Gerasimovskaya

  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Brookline Ave. 99, Boston, 02215, USA

    Elzbieta Kaczmarek

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Montesinos, M.C., Valls, M.D. (2010). Stimulation of Wound Revascularization by Adenosine Receptor Activation. In: Gerasimovskaya, E., Kaczmarek, E. (eds) Extracellular ATP and Adenosine as Regulators of Endothelial Cell Function. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3435-9_6

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