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Heat Shock Proteins and Whole Body Physiology pp 121–134Cite as

Heat Shock Proteins and Cancer

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Part of the book series: Heat Shock Proteins ((HESP,volume 5))

Abstract

Heat shock proteins (HSP) play multiple roles in cellular physiology and pathology depending on a wide variety of factors including its relative location within the cell (intracellular, plasma membrane or extracellular milieu), the age of the cell or whether it has undergone neoplastic transformation. In normal non-transformed cells, HSP play a cytoprotective role and protect cells from adverse stressful stimuli via chaperoning naïve, misfolded and/or denatured proteins by a process known as the stress response. However, cancer cells have commandeered this function and the result is increased resistance to a number of anti-cancer therapies including hyperthermia, radiation and a wide range of chemotherapeutic agents. Recent advances in our understanding of this dual role of HSP have led to the development of pharmacological and molecular tool to target HSP for therapeutic gain. In this chapter, we highlight evidence for the involvement of HSP in the pathology of various cancers and discuss their proposed mechanism of action and therapeutic potential

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Abbreviations

AP-1:

activator protein-1

AR:

androgen receptor

CRC:

colorectal cancer

CTL:

cytotoxic T lymphocytes

ERK:

extracellular-signal regulated kinase

GRP:

glucose regulated proteins

HBV:

hepatitis B virus

HCC:

hepatocellular carcinoma cells

HCV:

hepatitis C virus

HER:

human endothelial growth factor receptor

HSF:

heat shock factor

Hsp:

heat shock proteins

hsp :

heat shock protein gene

HSP:

heat shock protein family

HSP :

heat shock protein family gene

JAK/STAT:

janus-activated-kinase/signal transducer and activator of transcription

MAPK:

mitogen activated protein kinase

NK cells:

natural killer cells

NSCLC:

non-small cell lung cancer

PSA:

prostate specific antigen

SAPK/JNK:

stress-activated protein kinase/c-Jun N-terminal kinase

SCC:

squamous cell carcinoma

SCLC:

small cell lung cancer

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Acknowledgements

This work was supported in part by a grant from the Scott & White Memorial Hospital and Clinic (to G. M. N.), the National Institutes of Health grant RO1CA91889, institutional support from Scott & White Memorial Hospital and Clinic, Texas A&M University System Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A. A.).

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Authors and Affiliations

  1. Division of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic, Temple, TX, USA

    Ganachari M. Nagaraja

  2. Division of Investigative Pathology, The Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and Clinic, 1901 South First Street, Building 205, Room 1R36, Temple, TX, 76504, USA

    Alexzander Asea

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  1. Ganachari M. Nagaraja
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Correspondence to Alexzander Asea .

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Editors and Affiliations

  1. College of Medicine, Texas A & M University System, South 1st St. 1901, Temple, 76508, U.S.A.

    Alexzander A. A. Asea

  2. Rigshospitalet, University of Copenhagen, Blegdamsvej 9, Koebenhavn, 2100, Denmark

    Bente K. Pedersen

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Nagaraja, G.M., Asea, A. (2010). Heat Shock Proteins and Cancer. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_7

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