Abstract
Heat shock proteins (HSP) play an important role in human health and physiology and are known to function intracellularly as cytoprotection proteins by protecting cells against a wide variety of stressors, and extracellularly as chaperokines by stimulating the synthesis of pro-inflammatory cytokines, chemokines, and upregulates co-stimulatory molecule expression on antigen presenting cells, and enhancing natural killer (NK) cell-mediated migration and general anti-tumor responses. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. The recent findings that antibody titers to several HSP are elevated in dyslipidaemic patients and individuals with established vascular disease, and that patients with Type 2 diabetes have reduced gene expression of Hsp72 which correlates with reduced insulin sensitivity point to an important role for HSP in obesity and Type 2 diabetes. This chapter briefly reviews recent advances in our understanding of the role of Hsp70 in obesity and Type 2 diabetes
Keywords
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Learn about institutional subscriptionsAbbreviations
- BMI:
-
body mass index
- CDC:
-
center for disease control
- CRP:
-
C-reactive protein
- CVD:
-
cardiovascular disease
- FBG:
-
fasting blood glucose
- FFA:
-
free fatty acids
- GRP:
-
glucose regulated proteins
- HSF:
-
heat shock factor
- Hsp:
-
heat shock proteins
- hsp :
-
heat shock protein gene
- HSP:
-
heat shock protein family
- IGF-1:
-
insulin growth factor-1
- IL:
-
interleukin
- JNK:
-
c-jun N-terminal kinase
- MAPK:
-
mitogen activated protein kinases
- MCP-1:
-
monocyte chemotactic protein-1
- NK:
-
natural killer
- TNF-α:
-
tumor necrosis factor-alpha
- WHO:
-
World Health Organization
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Acknowledgements
The authors thank the Proteomics Core Facility at Scott & White Hospital and Clinic. This work was supported in part by the National Institutes of Health grant RO1CA91889, institutional support from Scott & White Memorial Hospital and Clinic, Texas A&M University System Health Science Center College of Medicine, the Central Texas Veterans Health Administration and an Endowment from the Cain Foundation (to A. A).
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Kaur, P., Reis, M.D., Couchman, G.R., Forjuoh, S.N., Greene, J.F., Asea, A. (2010). Role of Heat Shock Proteins in Obesity and Type 2 Diabetes. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_2
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