Abstract
This chapter reviews key exercise immunology findings from five years of research on 350 athletes in the 160-km Western States Endurance Run (WSER), a point-to-point trail run in the Sierra Nevada Mountains of northern California. Until this series of studies on WSER ultra-marathoners, little was known regarding the response of the immune system to severe exertion. This chapter describes how the immune system responds to running 160 km and underlying mechanisms including oxidative stress, muscle damage, inflammation, endotoxemia, and ibuprofen use
Keywords:
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- ALT:
-
alanine aminotransferase
- AST:
-
asparate aminotransferase
- BMI:
-
body mass index
- BUN:
-
blood urea nitrogen
- CK:
-
creatine kinase
- CRP:
-
C-reactive protein
- DOMS:
-
delayed onset of muscle soreness
- G-CSF:
-
granulocyte colony-stimulating factor
- IgA:
-
immunoglobulin A
- IL-6:
-
interleukin-6
- LPS:
-
lipopolysaccharide
- MCP-1:
-
monocyte chemoattractant protein 1
- MIF:
-
macrophage migration inhibitory factor
- MIP-1β:
-
macrophage inflammatory protein 1 beta
- NK:
-
natural killer
- NSAIDS:
-
Non-steroidal anti-inflammatory drugs
- RPE:
-
ratings of perceived exertion
- TNF-α:
-
tumor necrosis factor-alpha
- URTI:
-
upper respiratory tract infections
- WSER:
-
Western States Endurance Run
References
Akerström, T.C. and Pedersen, B.K. (2007). Strategies to enhance immune function for marathon runners: what can be done? Sports Med. 37, 416–419.
Bosenberg, A.T., Brock-Utne, J.G., Gaffin, S.L., Wells, M.T., and Blake, G.T. (1988). Strenuous exercise causes systemic endotoxemia. J. Appl. Physiol. 65, 106–108.
Brock-Utne, J.G., Gaffin, S.L., Wells, M.T. et al. (1988). Endotoxemia in exhausted runners after a long-distance race. S. Afr. Med. J. 73, 533–536.
Bruunsgaard, H., Galbo, H., Halkjaer-Kristensen, J., Johansen, T.L., MacLean, D.A., and Pedersen, B.K. (1997). Exercise-induced increase in serum interleukin-6 in humans is related to muscle damage. J. Physiol. 499(Pt 3), 833–841.
Bruunsgaard, H., Hartkopp, A., Mohr, T. et al. (1997). In vivo cell-mediated immunity and vaccination response following prolonged, intense exercise. Med. Sci. Sports Exerc. 29, 1176–1181.
Camus, G., Poortmans, J., Nys, M. et al. (1997). Mild endotoxemia and the inflammatory response induced by a marathon race. Clin. Sci. (Lond.) 92, 415–422.
Camus, G., Nys, M., Poortmans, J.R. et al. (1998). Endotoxemia, production of tumor necrosis factor alpha and polymorphonuclear neutrophil activation following strenuous exercise in humans. Eur. J. Appl. Physiol. 79, 62–68.
Donnelly, A.E., Maughan, R.J., and Whiting, P.H. (1990). Effects of ibuprofen on exercise-induced muscle soreness and indices of muscle damage. Br. J. Sports Med. 24, 191–195.
Dumke, C.L., Nieman, D.C., Oley, K., and Lind, R.H. (2007). Ibuprofen does not effect serum electrolytes following an ultradistance run. Br. J. Sports Med. 41, 492–496.
Farquhar, W.B., Morgan, A.L., Zambraski, E.J., and Kenney, W.L. (1999). Effect of acetaminophen and ibuprofen on renal function in the stressed kidney. J. Appl. Physiol. 86, 598–604.
Frydelund-Larsen, L., Penkowa, M., Akerstrom, T., Zankari, A., Nielsen, S., and Pedersen, B.K. (2007). Exercise induces interleukin-8 receptor (CXCR2) expression in human skeletal muscle. Exp. Physiol. 92, 233–240.
Gleeson, M. (2006). Immune system adaptation in elite athletes. Curr. Opin. Clin. Nutr. Metab. Care 9, 659–665.
Gleeson, M., McDonald, W.A., Pyne, D.B. et al. (1999). Salivary IgA levels and infection risk in elite swimmers. Med. Sci. Sports Exerc. 31, 67–73.
Gleeson, M., McDonald, W.A., Pyne, D.B. et al. (2000). Immune status and respiratory illness for elite swimmers during a 12-week training cycle. Int. J. Sports Med. 21, 302–307.
Gleeson, M. and Pyne, D.B. (2000). Special feature for the Olympics: effects of exercise on the immune system: exercise effects on mucosal immunity. Immunol. Cell. Biol. 78, 536–544.
Henson, D.A., Nieman, D.C., Davis, J.M. et al. (2008). Post-160-km race illness rates and decreases in granulocyte oxidative burst activity and salivary IgA output are not countered by quercetin ingestion. Int. J. Sports Med. 29, 856–863.
Jeukendrup, A.E., Vet-Joop, K., Sturk, A. et al. (2000). Relationship between gastro-intestinal complaints and endotoxemia, cytokine release and the acute-phase reaction during and after a long-distance triathlon in highly trained men. Clin. Sci. 98, 47–55.
Keller, C., Steensberg, A., Pilegaard, H. et al. (2001). Transcriptional activation of the IL-6 gene in human contracting skeletal muscle: influence of muscle glycogen content. FASEB J. 15, 2748–2750.
Kim, H.J., Lee, Y.H., and Kim, C.K. (2007). Biomarkers of muscle and cartilage damage and inflammation during a 200 km run. Eur. J. Appl. Physiol. 99, 443–447.
Krzywkowski, K., Petersen, E.W., Ostrowski, K. et al. (2001). Effect of glutamine and protein supplementation on exercise-induced decreases in salivary IgA. J. Appl. Physiol. 91, 832–838.
Lambert, G.P. (2004). Role of gastrointestinal permeability in exertional heatstroke. Exerc. Sport Sci. Rev. 32, 185–190.
Lambert, G.P., Broussard, L.J., Mason, B.L., Mauermann, W.J., and Gisolfi, C.V. (2001). Gastrointestinal permeability during exercise, effects of aspirin and energy-containing beverages. J. Appl. Physiol. 90, 2075–2080.
Lehtonen, O.P., Tenovuo, J., Aaltonen, A.S., and Vilja, P. (1987). Immunoglobulins and innate factors of immunity in saliva of children prone to respiratory infections. Acta. Pathol. Microbiol. Immunol. Scand. 95, 34–40.
McAnulty, S.R., McAnulty, L.S., Nieman, D.C., Morrow, J.D., Dumke, C.L., and Henson, D.A. (2007a). Effect of NSAID on muscle injury and oxidative stress. Int. J. Sports Med. 28, 909–915.
McAnulty, S.R., Owens, J.T., McAnulty, L.S. et al. (2007b). Ibuprofen use during extreme exercise: effects on oxidative stress and PGE2. Med. Sci. Sports Exerc. 39, 1075–1079.
Nielsen, H.G. and Lyberg, T. (2004). Long-distance running modulates the expression of leucocyte and endothelial adhesion molecules. Scand. J. Immunol. 60, 356–362.
Nielsen, S. and Pedersen, B.K. (2008). Skeletal muscle as an immunogenic organ. Curr. Opin. Pharmacol. 8, 346–351.
Nieman, D.C. (2000a). Exercise effects on systemic immunity. Immunol. Cell Biol. 78, 496–501.
Nieman, D.C. (2000b). Is infection risk linked to exercise workload? Med. Sci. Sports Exerc. 32(suppl 7), S406–S411.
Nieman, D.C. (2007). Marathon training and immune function. Sports Med. 37, 412–415.
Nieman, D.C., Davis, J.M., Henson, D.A. et al. (2003a). Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J. Appl. Physiol. 94, 1917–1925.
Nieman, D.C., Dumke, C.L., Henson, D.A., McAnulty, S.R., Gross, S.J., and Lind, R.L. (2005). Muscle damage is linked to cytokine changes following a 160-km race. Brain Beh. Immun. 19, 398–403.
Nieman, D.C., Dumke, C.L., Henson, D.A. et al. (2003b). Immune and oxidative changes during and following the Western States Endurance Run. Int. J. Sports Med. 24, 541–547.
Nieman, D.C., Henson, D.A., Davis, J.M. et al. (2006a). Blood leukocyte mRNA expression for IL-10, IL-1ra, and IL-8, but not IL-6, increases after exercise. J. Interferon Cytokine Res. 26, 668–674.
Nieman, D.C., Henson, D.A., Davis, J.M. et al. (2007). Quercetin ingestion does not alter cytokine changes in athletes competing in the Western States Endurance Run. J. Interferon Cytokine Res. 27, 1003–1012.
Nieman, D.C., Henson, D.A., Dumke, D.L., Lind, R.H., Shooter, L.R., and Gross, S.J. (2006b). Relationship between salivary IgA secretion and upper respiratory tract infection following a 160-km race. J. Sports Med. Phys. Fit. 46, 158–162.
Nieman, D.C., Henson, D.A., Fagoaga, O.R. et al. (2002a). Change in salivary IgA following a competitive marathon race. Int. J. Sports Med. 23, 69–75.
Nieman, D.C., Henson, D.A., McAnulty, S.R. et al. (2002b). Influence of vitamin C supplementation on oxidative and immune changes following an ultramarathon. J. Appl. Physiol. 92, 1970–1977.
Nieman, D.C., Henson, D.A., McAnulty, S.R. et al. (2004). Vitamin E and immunity after the Kona Triathlon World Championship. Med. Sci. Sports Exerc. 36, 1328–1335.
Nieman, D.C., Henson, D.A., Smith, L.L. et al. (2001). Cytokine changes after a marathon race. J. Appl. Physiol. 91, 109–114.
Nieman, D.C., Johansen, L.M., Lee, J.W., Cermak, J., and Arabatzis, K. (1990). Infectious episodes in runners before and after the Los Angeles Marathon. J. Sports Med. Phys. Fit. 30, 316–328.
Nieman, D.C., Oley, K., Henson, D.A. et al. (2006c). Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. Brain Beh. Immun. 20, 578–584.
Ostrowski, K., Schjerling, P., and Pedersen, B.K. (2000). Physical activity and plasma interleukin-6 in humans-effect of intensity of exercise. Eur. J. Appl. Physiol. 83, 512–515.
Palmer, F.M., Nieman, D.C., Henson, D.A. et al. (2003). Influence of vitamin C supplementation on oxidative and salivary IgA changes following an ultramarathon. Eur. J. Appl. Physiol. 89, 100–107.
Peters, E.M. and Bateman, E.D. (1983). Ultramarathon running and upper respiratory tract infections. An epidemiological survey. S. Afr. Med. J. 64, 582–584.
Peterson, J.M., Trappe, T.A., Mylona, E. et al. (2003). Ibuprofen and acetaminophen, effect on muscle inflammation after eccentric exercise. Med. Sci. Sports Exerc. 35, 892–896.
Pizza, F.X., Cavender, D., Stockard, A., Baylies, H., and Beighle, A. (1999). Anti-inflammatory doses of ibuprofen, effect on neutrophils and exercise-induced muscle injury. Int. J. Sports Med. 20, 98–102.
Peake, J.M. (2002). Exercise-induced alterations in neutrophil degranulation and respiratory burst activity: possible mechanisms of action. Exerc. Immunol. Rev. 8, 49–100.
Powers, S.K., DeRuisseau, K.C., Quindry, J., and Hamilton, K.L. (2004). Dietary antioxidants and exercise. J. Sports Sci. 22, 81–94.
Quindry, J.C., McAnulty, S.R., Hudson, M.B. et al. (2008). Oral quercetin supplementation and blood oxidative stress during ultra-marathon competition. Int. J. Sports Nutr. Exerc. Metab. 18, 601–616.
Ryan, A.J., Chang, R.T., and Gisolfi, C.V. (1996). Gastrointestinal permeability following aspirin intake and prolonged running. Med. Sci. Sports Exerc. 28, 698–705.
Smetanka, R.D., Lambert, G.P., Murray, R., Eddy, D., Horn, M., and Gisolfi, C.V. (1999). Intestinal permeability in runners in the 1996 Chicago marathon. Int. J. Sports Nutr. 9, 426–433.
Steensberg, A. (2003). The role of IL-6 in exercise-induced immune changes and metabolism. Exerc. Immunol. Rev. 9, 40–47.
Steensberg, A., Keller, C., Hillig, T. et al. (2007). Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle. FASEB J. 21, 2683–2694.
Steerenberg, P.A., Van Asperen, I.A., Van Nieuw Amerongen, A., Biewenga, A., Mol, D., and Medema, G.J. (1997). Salivary levels of immunoglobulin A in triathletes. Eur. J. Oral Sci. 105, 305–309.
Steinacker, J.M., Lormes, W., Reissnecker, S., and Liu, Y. (2004). New aspects of the hormone and cytokine response to training. Eur. J. Appl. Physiol. 91, 382–391.
Suzuki, K., Nakaji, S., Yamada, M., Totsuka, M., Sato, K., and Sugawara, K. (2002). Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc. Immunol. Rev. 8, 6–48.
Suzuki, K., Nakaji, S., Yamada, M. et al. (2003). Impact of a competitive marathon race on systemic cytokine and neutrophil responses. Med. Sci. Sports Exerc. 35, 348–355.
Suzuki, K., Totsuka, M., Nakaji, S. et al. (1999). Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage. J. Appl. Physiol. 87, 1360–1367.
Tomasi, T.B., Trudeau, F.B., Czerwinski, D., and Erredge, S. (1982). Immune parameters in athletes before and after strenuous exercise. J. Clin. Immunol. 2, 173–178.
Trappe, T.A., White, F., Lambert, C.P., Cesar, D., Hellerstein, M., and Evans, W.J. (2002). Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis. Am. J. Endrocrin. Metab. 282, E551–E556.
Van Nieuwenhoven, M.A., Brouns, F., and Brummer, R.J.M. (2004). Gastrointestinal profile of symptomatic athletes at rest and during physical exercise. Eur. J. Appl. Physiol. 91, 429–434.
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Nieman, D.C. (2010). Ultra Marathon Race Competition and Immune Function. In: Asea, A., Pedersen, B. (eds) Heat Shock Proteins and Whole Body Physiology. Heat Shock Proteins, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3381-9_16
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DOI: https://doi.org/10.1007/978-90-481-3381-9_16
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