Abstract
This paper presents a stochastic-elasticity model on the tension-induced growth of focal adhesions (FAs) at cell–substrate interface. The model is based on a Monte Carlo scheme incorporating applied tension, cell/substrate elasticity, receptor–ligand binding/unbinding and receptor diffusion in the same framework that fully couples elasticity and probabilistic rate processes in the system. We investigate the clustering of receptor molecules and growth of FAs under different levels of applied tension. While overly simplified in a number of aspects, our model seems to give predictions that are consistent with relevant experimental observations on the mechanosensitivity of FAs.
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Qian, J., Wang, J., Gao, H. (2010). Tension-Induced Growth of Focal Adhesions at Cell–Substrate Interface. In: Garikipati, K., Arruda, E. (eds) IUTAM Symposium on Cellular, Molecular and Tissue Mechanics. IUTAM Bookseries, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3348-2_16
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DOI: https://doi.org/10.1007/978-90-481-3348-2_16
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