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Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease pp 185–209Cite as

Heat Shock Proteins Are Mediators of Bacterial-Host Interactions

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Part of the book series: Heat Shock Proteins ((HESP,volume 4))

Abstract

A new paradigm of bacterial interactions with humans is predicated on the foundation that Homo sapiens are host to more than 1,000 bacterial species – the normal bacterial microbiota. The assumption is that such colonisation must create an enormous amount of signalling between our resident bacteria and our own cells. Exogenous and endogenous bacterial pathogens must contribute to this signalling and most of our information comes from a study of pathogenic bacteria. It is now emerging that molecular chaperones, and cell stress proteins generally, form part of this communications network. Indeed, they may form an important part, as it is likely that mutual stress responses are involved in controlling our interactions with bacteria and their response to us. This chapter provides an overview of the recent literature emerging on the role of stress proteins in bacteria–host interactions

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  1. UCL Eastman Dental Institute, University College London, WC1X 8LD, London, UK

    Brian Henderson

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  1. School of Medicine & Biomedical Science, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, United Kingdom

    A. Graham Pockley

  2. Beth Israel Deaconess Medical Center, Harvard Medical School, Burlington Avenue 21-27, Boston, 02215, U.S.A.

    Stuart K. Calderwood

  3. Dipto. Biologia, Università di Roma, Tor Vergata, Via della Ricerca Scientifica 1, Roma, 00133, Italy

    M. Gabriella Santoro

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Henderson, B. (2009). Heat Shock Proteins Are Mediators of Bacterial-Host Interactions. In: Pockley, A., Calderwood, S., Santoro, M. (eds) Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease. Heat Shock Proteins, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2976-8_10

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