Skip to main content
SpringerLink
Log in
Book cover

Methods of Cancer Diagnosis, Therapy, and Prognosis pp 147–155Cite as

Wilms Tumor: Prognosis Using Microvessel Density

  • Chapter
  • First Online:

  • 1591 Accesses

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 6))

Abstract

Wilms tumor (WT), the most common malignant neoplasm of the kidney in infants and children, is a triphasic tumor that mimics various stages of nephrogenesis, composed of epithelial, blastemal and stromal cells. More than 90% of the cases occur in children less than 6-years of age, mostly between 2 and 5 years. WT has overall survival rates exceeding 90% by the improvement of surgical and anesthetic procedures, and the combination of chemotherapy and radiotherapy (D’Angio et al. 1989; Argani and Beck­with 2004).

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Abramson, L.P., Grundy, P.E., Rademaker, A.W., Helenowski, I., Cornwell, M., Katzenstein, H.M., Reynolds, M., Arensman, R.M,. and Crawford, S.E. (2003) Increased microvessel density predicts relapse in Wilms’ tumor. J. Pediatr. Surg. 38:325–330

    Article  PubMed  Google Scholar 

  • Argani, P,. and Beckwith, J.B. (2004) Renal neoplasms of childhood. In: Mills, S.E., Carter, D., Greenson, J.K., Oberman, H.A., Reuter, V., Stoler MH (eds) Diagnostic surgical pathology., 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 2001–2033

    Google Scholar 

  • Beckwith JB (1994) Tumors of infancy and childhood. In: Murphy, W.M., Beckwith, J.B., Farrow GM (eds) Tumors of the kidney., bladder, and related urinary structures. Atlas of tumor pathology. 3rd series., Fascicle 11. Washington DC: Armed Forces Institute of Pathology., pp. 12–91

    Google Scholar 

  • Beckwith JB (1998) National Wilms Tumor Study: an update for pathologists. Pediatr. Dev. Pathol. 1:79–84

    Article  PubMed  CAS  Google Scholar 

  • Chalkley HW (1943) Method for the quantitative morphologic analysis of tissues. J. Natl. Cancer. Inst 4:47–53

    Google Scholar 

  • Chantrain, C.F., DeClerck, Y.A., Groshen, S,. and McNamara, G. (2003) Computerized quantification of tissue vascularization using high-resolution slide scanning of whole tumor sections. J. Histochem. Cytochem. 51:151–158

    Article  PubMed  CAS  Google Scholar 

  • D’Angio, G.J., Breslow, N., Beckwith, J.B., Evans, A., Baum, H., deLorimier, A., Fernbach, D., Hrabovsky, E., Jones, B., Kelalis, P., Othersen, B., Tefft, M,. and Thomas PRM. (1989) Treatment of Wilms’ tumor: results of the third National Wilms’ Tumor Study. Cancer 64:349–360

    Article  PubMed  Google Scholar 

  • Derynck R (1992) The physiology of transforming growth factor-alpha. Adv. Cancer. Res. 58:27

    Article  PubMed  CAS  Google Scholar 

  • Folkman J (1971) Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285:1182–1186

    Article  PubMed  CAS  Google Scholar 

  • Folkman J (1986) How is blood vessel growth regulated in normal. and neoplastic tissue.? G H A Clowes Memorial Award Lecture. Cancer. Res. 46:467–473

    PubMed  CAS  Google Scholar 

  • Fox, S.B., Leek, R.D., Weekes, M.P., Whitehouse, R.M., Gatter, K.C,. and Harris, A.L. (1995) Quantitation and prognostic value of breast cancer angiogenesis: comparison of microvessel density., Chalkley count., and computer image analysis. J. Pathol. 177:275–283

    Article  PubMed  CAS  Google Scholar 

  • Fox, S.B., Gatter, K.C., Leek, R.D., Harris, A.L., Chew, K.L., Mayall, B.H,. and Moore, D.H. (2000) More about: Tumor angiogenesis as a prognostic assay for invasive ductal breast carcinoma. J. Natl. Cancer. Inst. 92:161–162

    Article  PubMed  CAS  Google Scholar 

  • Frischer, J.S., Huang, J., Serur, A., Kadenhe-Chiweshe, A., McCrudden, K.W., O’Toole, K., Holash, J., Yancopoulos, G.D., Yamashiro, D.J,. and Kandel, J.J. (2004) Effects of potent VEGF blockade on experimental Wilms tumor. and its persisting. vasculature. Int. J. Oncol. 25:549–553

    PubMed  CAS  Google Scholar 

  • Ghanem, M.A., van Steenbrugge, G.J., Sudaryo, M.K., Mathoera, R.B., Nijman, J.M., van der Kwast T (2003) Expression and prognostic relevance of vascular endothelial growth factor (VEGF) and its receptor (FLT-1) in nephroblastoma. J. Clin. Pathol. 56:107–113

    Article  PubMed  CAS  Google Scholar 

  • Hansen, S., Sørensen, F.B., Vach, W., Grabau, D.A., Bak, M,. and Rose, C. (2004) Microvessel density compared with the Chalkley count in a prognostic study of angiogenesis in breast cancer patients. Histopathology 44:428–436

    Article  PubMed  CAS  Google Scholar 

  • Hlatky, L., Hahnfeldt, P,. and Folkman, J. (2002) Clinical application of antiangiogenic therapy: microvessel density., what it does and doesn’t tell us. J. Natl. Cancer. Inst. 94:883–893

    Article  PubMed  Google Scholar 

  • Huang, J., Moore, J., Soffer, S., Kim, E., Rowe, D., Manley, C.A., O’Toole, K., Middlesworth, W., Stolar, C., Yamashiro, D,. and Kandel, J.J. (2001) Highly specific antiangiogenic therapy is effective in suppressing growth of experimental Wilms tumors. J. Pediatr. Surg. 36:357–361

    Article  PubMed  CAS  Google Scholar 

  • Karth, J., Ferrer, F.A., Perlman, E., Hanrahan, C., Simons, J.W., Gearhart, J.P,. and Rodriguez, R. (2000) Coexpression of hypoxia-inducable factor 1-alpha and vascular endothelial growth factor in Wilms’ tumor. J. Pediatr. Surg. 35:1749–1753

    Article  PubMed  CAS  Google Scholar 

  • Kayton, M.L., Rowe, D.H., O’Toole, M., Thompson, R.B., Schwartz, M.A., Stolar CJH,. and Kandel, J.J. (1999) Metastasis correlates with production of vascular endothelial growth factor in a murine model of human Wilms’ tumor. J. Pediatr. Surg. 34:743–748

    Article  PubMed  CAS  Google Scholar 

  • Kim, E., Moore, J., Huang, J., Soffer, S., Manley, C.A., O’Toole, K., Middlesworth, W., Stolar, C.J., Kandel, J.J,. and Yamashiro, D.J. (2001) All angiogenesis is not the same: distinct patterns of response to antiangiogenic therapy in experimental neuroblastoma. and Wilms tumor.. J. Pediatr. Surg. 36:287–290

    Article  PubMed  CAS  Google Scholar 

  • Lehr, H.A., Mankoff, D.A., Corwin, D., Santeusanio, G,. and Gown, A.M. (1997) Application of photoshop-based image analysis to quantification of hormone receptor expression in breast cancer. J. Histochem. Cytochem. 45:1559–1565

    Article  PubMed  CAS  Google Scholar 

  • Mineo, T.C., Ambrogi, V., Baldi, A., Rabitti, C., Bollero, P., Vincenzi, B,. and Tonini, G. (2004) Prognostic impact of VEGF., CD31, CD34, and CD105 expression and tumour vessel invasion after radical surgery for IB-IIA non-small cell lung cancer. J. Clin. Pathol. 57:591–597

    Article  PubMed  CAS  Google Scholar 

  • Offersen, B.V., Borre, M,. and Overgaard, J. (2003) Quantification of angiogenesis as a prognostic marker in human carcinomas: a critical evaluation of histopathological methods for estimation of vascular density. Eur. J. Cancer. 39:881–890

    Article  PubMed  CAS  Google Scholar 

  • Ozluk, Y., Kilicaslan, I., Gulluoglu, M.G., Ayan, I,. and Uysal, V. (2006) The prognostic significance of angiogenesis. and the effect. of vascular endothelial growth factor on angiogenic process in Wilms’ tumour. Pathology 38:408–414

    Article  PubMed  CAS  Google Scholar 

  • Qualman, S.J., Bowen, J., Amin, M.B., Srigley, J.R., Grundy, P.E,. and Perlman, E.J. (2003) Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhood. Arch. Pathol. Lab. Med. 127:1280–1289

    PubMed  Google Scholar 

  • Rowe, D.H., Kayton, M.L., O’Toole, K., Ingram, M., Stolar CJH,. and Kandel, J.J. (1999) Pathological angiogenesis in a murine model of human Wilms’ tumor. J. Pediatr. Surg. 34:676–679

    Article  PubMed  CAS  Google Scholar 

  • Rowe, D.H., Huang, J., Katyon, M.L., Thompson, R., Troxel, A., O’Toole, K.M., Yamashiro, D., Stolar, C.J,. and Kandel, J.J. (2000) Anti-VEGF antibody suppresses primary tumor growth. and metastasis in. an experimental model of Wilms tumor. J. Pediatr. Surg. 35:30–33

    Article  PubMed  CAS  Google Scholar 

  • Salvesen, H.B., Gulluoglu, M.G., Stefansson, I,. and Akslen, L.A. (2003) Significance of CD105 expression for tumour angiogenesis. and prognosis in. endometrial carcinomas. APMIS 111:1011–1018

    Article  PubMed  Google Scholar 

  • Sköldenberg, E.G., Christiansson, J., Sandstedt, B., Larsson, A., Läckgren, G,. and Christofferson, R. (2001) Angiogenesis and angiogenic growth factors in Wilms tumor. J. Urol. 165:2274–2279

    Article  PubMed  Google Scholar 

  • Soffer, S.Z., Moore, J.T., Kim, E., Huang, J., Yokoi, A., Manley, C., O’Toole, K., Stolar, C., Middlesworth, W., Yamashiro, D.J,. and Kandel, J.J. (2001) Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor. J. Pediatr. Surg. 36:1177–1181

    Article  PubMed  CAS  Google Scholar 

  • Uzzan, B., Nicolas, P., Cucherat, M., Perret G-Y (2004) Microvessel density as a prognostic factor in women with breast carcinoma: a systematic review of the literature and meta-analysis. Cancer. Res. 64:2941–2955

    Article  PubMed  CAS  Google Scholar 

  • Vermeulen, P.B., Gasparini, G., Fox, S.B., Toi, M., Martin, L., McCulloch, P., Pezzella, F., Viale, G., Weidner, N., Harris, A.L,. and Dirix, L.Y. (1996) Quantification of angiogenesis in solid human tumours: an international consensus on the methodology. and criteria of. evaluation. Eur. J. Cancer. 32A:2474–2484

    Article  PubMed  CAS  Google Scholar 

  • Vieira, S.C., Zeferino, L.C., Da Silva, B.B., Aparecida Pinto, G., Vassallo, J., Carasan, G.A., De Moraes NG (2004) Quantification of angiogenesis in cervical cancer: a comparison among three endothelial cell markers. Gynecol. Oncol. 93:121–124

    Article  PubMed  CAS  Google Scholar 

  • Weidner N (1995) Intratumor microvessel density as a prognostic factor in cancer. Am. J. Pathol. 147:9–19

    PubMed  CAS  Google Scholar 

  • Weidner, N., Semple, J.P., Welch, W.R,. and Folkman, J. (1991) Tumor angiogenesis and metastasis – correlation in invasive breast carcinoma. N. Engl. J. Med. 324:1–8

    Article  PubMed  CAS  Google Scholar 

  • Weidner, N., Folkman, J., Poza, F., Bevilacqua, P., Allred, E.N., Moore, D.H., Meli, S,. and Gasparini, G. (1992) Tumor angiogenesis: a new significant. and independent prognostic. indicator in early-stage breast carcinoma. J. Natl. Cancer. Inst. 84:1875–1887

    Article  PubMed  CAS  Google Scholar 

  • Weidner, N., Carroll, P.R., Flax, J., Blumenfeld, W,. and Folkman, J. (1993) Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143:401–409

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements.

I thank Prof. Isin Kilicaslan and Ass. Prof. Mine G.Gulluoglu for sharing their experience and time during the preparation of this text.

Author information

Authors and Affiliations

  1. Department of Pathology, Istanbul University, Capa, Topkapi, Istanbul, 34390, Turkey

    Yasemin Ozluk (Faculty of Medicine)

Authors
  1. Yasemin Ozluk
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dept. Biological Sciences, Kean University, Union, 07083, U.S.A.

    M. A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Ozluk, Y. (2010). Wilms Tumor: Prognosis Using Microvessel Density. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2918-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-90-481-2918-8_13

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-481-2917-1

  • Online ISBN: 978-90-481-2918-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation