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Identification of Biomarkers for Clear Cell Ovarian Adenocarcinoma

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Methods of Cancer Diagnosis, Therapy, and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 6))

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Abstract

Ovarian cancer is the fifth most common form of cancer in women in the United States, accounting for 4% of the total number of cancer cases and 25% of those cases occur in the female genital tract. Because of its low cure rate, it is responsible for 5% of all cancer deaths in women. It was estimated that 12,180 deaths would be caused by ovarian cancer in the year 2006 (Jemal et al. 2006).

Epithelial ovarian tumors are classified as benign, low malignant potential (LMP), or malignant (Serov and Scully 1973) and further distinguished by differences in the histologic type of cell. Benign ovarian tumors are lined by a single, or minimally stratified layer of cells, which are columnar and often ciliated in serous tumors or contain abundant apical cytoplasmic mucin in mucinous tumors. LMP tumors or borderline tumors (BOT) are characterized by atypical epitheliums with cellular proliferation and pleomorphism, but without stromal invasion. Malignant epithelium demonstrates marked atypia, increased mitotic activity, and stromal invasion.

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Acknowledgment

This study was supported in part by a grant from Osaka City General Hospital, Osaka Japan, and R33 CA103595 from National Institute of Health, Department of Health and Human Services, Bethesda, MD.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, M.D. Anderson Cancer Center, T403908, 1515 Holcombe Boulevard, Houston, TX, 77030, USA

    Samuel C. Mok

  2. Cell and Cancer Biology, National Cancer Institute, 37 Convent Drive, Room 1068, Bethesda, MD, 20892, USA

    Michael P. Stanley & Michael J. Birrer

  3. Department of Obstetrics and Gynecology, Osaka City General Hospital, 2-13-22 Miyakojimahondori, Miyakohima, Osaka, 5340021, Japan

    Hiroshi Tsuda

Authors
  1. Samuel C. Mok
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  2. Michael P. Stanley
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  3. Hiroshi Tsuda
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  4. Michael J. Birrer
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Corresponding author

Correspondence to Samuel C. Mok .

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Editors and Affiliations

  1. Dept. Biological Sciences, Kean University, Union, 07083, U.S.A.

    M. A. Hayat

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Mok, S.C., Stanley, M.P., Tsuda, H., Birrer, M.J. (2010). Identification of Biomarkers for Clear Cell Ovarian Adenocarcinoma. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2918-8_1

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  • DOI: https://doi.org/10.1007/978-90-481-2918-8_1

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