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Mechanosensitivity of the Heart pp 141–167Cite as

Stretch-Activated Channels in the Heart: Contribution to Cardiac Performance

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Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 3))

Abstract

Stretch-activated ion channels are widely expressed in most cell types and play an important role in a variety of normal cell functions, including volume regulation and length detection. In the heart, transduction of mechanical energy into cellular responses is an essential component of cardiac function. The heart is passively stretched, and actively shortens in every cardiac cycle; in addition, longer-term changes in volume occur during exercise, and in diseases such as heart failure. In this article, we discuss the importance of stretch-activated ion channels as mechano-transducers in the heart, with emphasis on their contribution to the regulation of contractile performance. As well, the role of stretch-activated channels in modifying the electrical activity of the heart is also discussed.

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Acknowledgments

Our work was supported by the National Health and Medical Research Council of Australia. M-L Ward gratefully acknowledges financial support from the P. J. Smith NZ Freemason’s Travelling Fellowship. The authors would also like to thank Dr Patricia Cooper for comments and discussion on this manuscript.

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Authors and Affiliations

  1. Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

    Marie-Louise Ward

  2. School of Medical Sciences, Institute for Biomedical Sciences, University of Sydney F13, NSW 2006, Sydney, Australia

    David G. Allen

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  1. Marie-Louise Ward
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  2. David G. Allen
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Correspondence to Marie-Louise Ward .

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Editors and Affiliations

  1. Dept. Fundamental &, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Andre Kamkin

  2. Dept. Fundamental &, Russian State Medical University, Ostrovitjanova Str. 1, Moskva, 117997, Russian Federation

    Irina Kiseleva

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Ward, ML., Allen, D.G. (2010). Stretch-Activated Channels in the Heart: Contribution to Cardiac Performance. In: Kamkin, A., Kiseleva, I. (eds) Mechanosensitivity of the Heart. Mechanosensitivity in Cells and Tissues, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2850-1_6

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