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Linking Human RecQ Helicases to DNA Damage Response and Aging

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The DNA Damage Response: Implications on Cancer Formation and Treatment

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Abstract

Maintenance of genome integrity is crucial for the survival of an organism. Increasing evidence suggests that defective DNA damage response promotes genome instability and accelerates age-related degeneration. The RecQ family of DNA helicases plays important roles in DNA replication and the DNA damage response. There are five human RecQ helicases, amongst which mutations in BLM, WRN, and RECQ4 have been linked to human diseases displaying symptoms of accelerated aging to various degrees. Recent studies have provided new insights into the mechanisms that control early stages of the DNA damage response, and shed light on common roles of the RecQ helicases in DNA replication and the DNA damage response. Here, we review the evidence for defective DNA damage response being a feature linking mutations in RecQ helicases to premature aging diseases. Data are accumulating to suggest that RecQ helicases impart signaling and repair functions in the response to DNA damage.

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Acknowledgments

This work was partially supported by the Intramural Research Program of the NIH, National Institute on Aging, and also by a Korean Research Foundation Grant of the Korean Government (MOEHRD) (KRF-2007-412-J00303, KRF-2007-521-C00211) to B. Ahn.

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Authors and Affiliations

  1. Department of Nutrition and Food Science, University of Maryland, 20742, College Park, MD, USA

    Wen-Hsing Cheng

  2. Department of Life Sciences, University of Ulsan, 680-749, Ulsan, Korea

    Byungchan Ahn

  3. Laboratory of Molecular Gerontology, Gerontology Research Center, National Institute on Aging, NIH, 21224, Baltimore, MD, USA

    Vilhelm A. Bohr

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  1. Wen-Hsing Cheng
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  2. Byungchan Ahn
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  3. Vilhelm A. Bohr
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Correspondence to Wen-Hsing Cheng , Byungchan Ahn or Vilhelm A. Bohr .

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  1. Signal Transduction Laboratory, Queensland Institute of Medical Research, Herston Road 300, Herston, 4006, Australia

    Kum Kum Khanna

  2. Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Yosef Shiloh

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Cheng, WH., Ahn, B., Bohr, V.A. (2009). Linking Human RecQ Helicases to DNA Damage Response and Aging. In: Khanna, K., Shiloh, Y. (eds) The DNA Damage Response: Implications on Cancer Formation and Treatment. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2561-6_15

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