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Imaging of Prosthetic Joints pp 27–37Cite as

Bone Remodeling

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Abstract

Skeletal buildup and maintenance is ensured by modeling and remodeling processes. Bone modeling works mainly during organism growth and is characterized by bone formation prevailing on resorption: The two processes are carried out simultaneously but not at the same location. In the bone remodeling, occurring throughout the life, osteoclasts remove the old bone, and osteoblasts replace it with the equal amount at the same site. The control of bone modeling and remodeling is very complex and involves both mechanical forces and biological factors. These include either circulating hormones, such as growth hormone, estrogen, androgen, PTH, and locally produced factors, such as Wnt signaling molecules and bone morphogenetic proteins. This chapter describes the sequential phases of bone remodeling as well as the last knowledge about its regulation by mechanical loading, circulating, and locally produced molecules.

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Neurosciences and Sense Organs, Section of Human Anatomy and Histology “Rodolfo Amprino”, University of Bari, Piazza Giulio Cesare, 11, 70124, Bari, BA, Italy

    Giacomina Brunetti & Adriana Di Benedetto

  2. Department of Clinical and Experimental Medicine, University of Foggia, Via L. Pinto 1, 71100, Foggia, FG, Italy

    Giorgio Mori

Authors
  1. Giacomina Brunetti
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  2. Adriana Di Benedetto
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  3. Giorgio Mori
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Correspondence to Giacomina Brunetti .

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Editors and Affiliations

  1. Department of Radiological Sciences, Oncology and Pathology, University of Rome Sapienza, Rome, Italy

    Carlina V. Albanese

  2. Radiodiagnostica CTO, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino, Italy

    Carlo Faletti

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Brunetti, G., Di Benedetto, A., Mori, G. (2014). Bone Remodeling. In: Albanese, C.V., Faletti, C. (eds) Imaging of Prosthetic Joints. Springer, Milano. https://doi.org/10.1007/978-88-470-5483-7_3

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  • DOI: https://doi.org/10.1007/978-88-470-5483-7_3

  • Publisher Name: Springer, Milano

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