Skip to main content

Adrenal Glands

  • Chapter
  • First Online:
CT of the Retroperitoneum
  • 1297 Accesses

Abstract

Most of adrenal lesions are incidentally discovered during imaging examinations for unrelated reasons. The majority of adrenal adenomas contain large amounts of intracytoplasmic lipid and are easily distinguished from non-adenomatous lesions on unenhanced multi-detector CT (MDCT). However, adenomas containing relatively small amounts of lipid account for approximately 30 % of all adenomas and cannot be distinguished from non-adenomatous lesions on the basis of unenhanced MDCT. Therefore, contrast-enhanced MDCT with washout  % calculation is necessary for these lesions. By exploiting the properties of lipid-containing tissues, spectral MDCT provides advantage in adrenal lesions characterization. As a result, unenhanced CT may be omitted from adrenal MDCT protocol if a dual-energy acquisition is performed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Young WF Jr (2007) The incidentally discovered adrenal mass. N Engl J Med 356:601–610

    Article  PubMed  CAS  Google Scholar 

  2. Boland GW, Blake MA, Hahn PF, Mayo-Smith WW (2008) Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology 249:756–775

    Article  PubMed  Google Scholar 

  3. Boland GW (2011) Adrenal Imaging. Abdom Imaging 36:472–482

    Article  PubMed  Google Scholar 

  4. Song J, Chaudhry FS, Mayo-Smith WW (2008) The incidental adrenal mass on CT: prevalence of adrenal disease in 1,049 consecutive adrenal masses in patients with no known malignancy. AJR Am J Roentgenol 190:1163–1168

    Article  PubMed  Google Scholar 

  5. Dunnick NR, Korobkin M (2002) Imaging of adrenal incidentalomas. AJR Am J Roentgenol 179:559–568

    Article  PubMed  Google Scholar 

  6. Lee MJ, Hahn PF, Papanicolou N et al (1991) Benign and malignant adrenal masses: CT distinction with attenuation coefficients, size, and observer analysis. Radiology 179:415–418

    PubMed  CAS  Google Scholar 

  7. Blake MA, Cronin CG, Boland GW (2010) Adrenal Imaging. AJR Am J Roentgenol 194:1450–1460

    Article  PubMed  Google Scholar 

  8. Dunnick NR, Korobkin M (2002) Imaging of adrenal incidentalomas: current status. AJR 179:559–568

    Article  PubMed  Google Scholar 

  9. Lam KY, Lo CY (2002) Metastatic tumours of the adrenal glands: a 30-year experience in a teaching hospital. Clin Endocrinol 56:95–101

    Article  Google Scholar 

  10. Mitchell IC, Nwariaku FE (2007) Adrenal masses in the cancer patient: surveillance or excision. Oncologist 12:168–174

    Article  PubMed  Google Scholar 

  11. Bovio S, Cataldi A, Reimondo G et al (2006) Prevalence of adrenal incidentaloma in a contemporary computerized tomography series. J Endocrinol Invest 29:298–302

    PubMed  CAS  Google Scholar 

  12. Boland GWL, Blake MA, Hahn PF, Mayo-Smith WW (2008) Incidental adrenal lesions: principles, techniques, and algorithms for imaging characterization. Radiology 249:756–775

    Article  PubMed  Google Scholar 

  13. Angeli A, Osella G, Ali A et al (1997) Adrenal incidentaloma: an overview of clinical and epidemiological data from the National Italian Study Group. Horm Res 47:279–283

    Article  PubMed  CAS  Google Scholar 

  14. Ettinghausen SE, Burt ME (1991) Prospective evaluation of unilateral adrenal masses in patients with operable non-small-cell lung cancer. J Clin Oncol 9:1462–1466

    PubMed  CAS  Google Scholar 

  15. Korobkin M, Giordano TJ, Brodeur FJ et al (1996) Adrenal adenomas: relationship between histologic lipid and CT and MR findings. Radiology 200:743–747

    PubMed  CAS  Google Scholar 

  16. Anderson JB, Gray GF (1989) Adrenal pathology. In: Vaughan ED, Carey RM (eds) Adrenal disorders. Thieme Medical, New York, pp 18–19

    Google Scholar 

  17. Carney JA (1992) Adrenal gland. In: Sternberg SS (ed) Histology for pathologists. Raven, New York, pp 150–154

    Google Scholar 

  18. Lee MJ, Hahn PF, Papanicolau N et al (1991) Benign and malignant adrenal masses: CT distinction with attenuation coefficients, size, and observer analysis. Radiology 179:415–418

    PubMed  CAS  Google Scholar 

  19. Caoili EM, Korobkin M, Francis IR et al (2002) Adrenal masses: characterization with combined unenhanced and delayed enhanced CT. Radiology 222:629–633

    Article  PubMed  Google Scholar 

  20. Hahn PF, Blake MA, Boland GW (2006) Adrenal lesions: attenuation measurement differences between CT scanners. Radiology 240:458–463

    Article  PubMed  Google Scholar 

  21. Boland GWL (2010) Adrenal Imaging: Why, When, What, and How? Part 1. Why and When to Image? AJR Am J Roentgenol 95:W377–W381

    Article  Google Scholar 

  22. Boland GWL (2011) Adrenal imaging: why, when, what, and how? Part 2. Why and when to image? AJR Am J Roentgenol 196:W1–W5

    Article  PubMed  Google Scholar 

  23. Boland GWL (2011) Adrenal imaging: why, when, what, and how? Part 3. The algorithmic approach to definitive characterization of the adrenal incidentaloma. AJR Am J Roentgenol 196:W109–W111

    Article  PubMed  Google Scholar 

  24. Bae KT, Fuangtharnthip P, Prasad SR, Joe BN, Heiken JP (2003) Adrenal masses: CT characterization with histogram analysis method. Radiology 228:735–742

    Article  PubMed  Google Scholar 

  25. Remer EM, Motta-Ramirez GA, Shepardson LB, Hamrahian AH, Herts BR (2006) CT histogram analysis in pathologically proven adrenal masses. AJR Am J Roentgenol 187:191–196

    Article  PubMed  Google Scholar 

  26. Ho LM, Paulson EK, Brady MJ, Wong TZ, Schindera ST (2008) Lipid-Poor adenomas on unenhanced CT: does histogram analysis increase sensitivity compared with a mean attenuation threshold? AJR Am J Roentgenol 191:234–238

    Article  PubMed  Google Scholar 

  27. Perri M, Erba P, Volterrani D et al (2011) Adrenal masses in patients with cancer: PET/CT characterization with combined CT histogram and standardized uptake value PET analysis. AJR Am J Roentgenol 197:209–216

    Article  PubMed  Google Scholar 

  28. Korobkin M, Brodeur FJ, Francis IR, Quint LE, Dunnick NR, Londy F (1998) CT time-attenuation wash-out curves of adrenal adenomas and nonadenomas. AJR Am J Roentgenol 170:747–752

    Article  PubMed  CAS  Google Scholar 

  29. Szolar DH, Kammerhuber FH (1998) Adrenal adenomas and nonadenomas: assessment of wash-out at delayed contrast-enhanced CT. Radiology 207:369–375

    PubMed  CAS  Google Scholar 

  30. Boland GW, Hahn PF, Pena C, Mueller PR (1997) Adrenal masses: characterization with delayed contrast-enhanced CT. Radiology 202:693–696

    PubMed  CAS  Google Scholar 

  31. Kloos RT, Gross MD, Francis IR et al (1995) Incidentally discovered adrenal masses. Endocr Rev 16:460–484

    PubMed  CAS  Google Scholar 

  32. Korobkin M (2000) CT characterization of adrenal masses: the time has come. Radiology 217:629–632

    PubMed  CAS  Google Scholar 

  33. Pena CS, Boland GW, Hahn PF, Lee MJ, Mueller PR (2000) Characterization of indeterminate (lipid-poor) adrenal masses: use of washout characteristics at contrast-enhanced CT. Radiology 217:798–802

    PubMed  CAS  Google Scholar 

  34. Blake MA, Kalra MK, Sweeney AT et al (2005) Distinguishing benign from malignant adrenal masses: multi-detector row CT protocol with 10-minute delay. Radiology 238:578–585

    Article  PubMed  Google Scholar 

  35. Kamiyama T, Fukukura Y, Yoneyama T, Takumi K, Nakajo M (2008) Distinguishing adrenal adenomas from nonadenomas: combined use of diagnostic parameters of unenhanced and short 5-minute dynamic enhanced CT protocol. Radiology 250:474–481

    Article  PubMed  Google Scholar 

  36. Sangwaiya MJ, Boland GWL, Cronin CG, Blake MA, Halpern EF, Hahn PF (2010) Incidental adrenal lesions: accuracy of characterization with contrast-enhanced washout multidetector CT—10-minute delayed imaging protocol revisited in a large patient cohort. Radiology 256:504–510

    Article  PubMed  Google Scholar 

  37. Gupta RT, Ho LM, Marin D, Boll DT, Barnhart HX, Nelson RC (2010) Dual energy CT for characterization of adrenal nodules: initial experience. AJR Am J Roentgenol 194:1479–1483

    Article  PubMed  Google Scholar 

  38. Coursey CA, Nelson RC, Boll DT et al (2010) Dual-energy multidetector CT: how does it work, what can it tell us, and when can we use it in abdominopelvic imaging? Radiographics 30:1037–1055

    Article  PubMed  Google Scholar 

  39. Kalra M, Blake M, Sahani D, Hahn P, Mueller P, Boland G (2007) Dual energy CT for characterization of adrenal adenomas (abstr). In: Radiological Society of North America scientific assembly and annual meeting program. Oak Brook, Ill: Radiological Society of North America, 347

    Google Scholar 

  40. Boland G, Jagtiani M, Kambadakone Ramesh A, Hahn P, Sahani D, Kalra M (2008) Characterization of lipid poor adrenal adenomas: accuracy of dual energy CT (abstr). In: Radiological Society of North America scientific assembly and annual meeting program. Oak Brook, Ill: Radiological Society of North America, 390

    Google Scholar 

  41. Gnannt R, Fischer M, Goetti R, Karlo C, Leschka S, Alkadhi H (2012) Dual-energy CT for characterization of the incidental adrenal mass: preliminary observations. AJR Am J Roentgenol 198:138–144

    Article  PubMed  Google Scholar 

  42. Ho LM, Marin D, Neville AM et al (2012) Characterization of adrenal nodules with dual-energy CT: Can virtual unenhanced attenuation values replace true unenhanced attenuation values? AJR Am J Roentgenol 198:840–845

    Article  PubMed  Google Scholar 

  43. Kim YK, Park BK, Kim CK, Park SY (2013) Adenoma characterization: adrenal protocol with dual-energy CT. Radiology 267:155–163

    Article  PubMed  Google Scholar 

  44. Mayo-Smith WW, Boland GW, Noto RB et al (2001) State-of-the-art adrenal imaging. Radiographics 21:995–1012

    PubMed  CAS  Google Scholar 

  45. Slattery JM, Blake MA, Kalra MK et al (2006) Adrenocortical carcinoma: contrast wash- out characteristics on CT. AJR Am J Roentgenol 187:W21–W24

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rendon C. Nelson .

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer-Verlag Italia

About this chapter

Cite this chapter

Mileto, A., Marin, D., Ho, L.M., Nelson, R.C. (2014). Adrenal Glands. In: CT of the Retroperitoneum. Springer, Milano. https://doi.org/10.1007/978-88-470-5469-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-5469-1_6

  • Published:

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5468-4

  • Online ISBN: 978-88-470-5469-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics