Background
Celiac disease (CD) is a genetic autoimmune disease in which affected individuals are unable to tolerate foods containing gluten, a specific protein of wheat, barley, and other cereals. The abnormal immune response in the intestine triggered by gluten generates a chronic inflammation and results in tissue damage to the small intestine, with the disappearance of the intestinal villi. If CD is not promptly diagnosed and treated, important and, in some cases, irreversible complications may occur [1]. In the most severe manifestations, CD can promote tumor development in the small bowel, such as intestinal lymphoma or adenocarcinoma. Especially in the initial phase of CD, the differential diagnosis will include lymphoma and other diseases [2]. Since the symptoms and endoscopic picture may be similar and non-specific, the diagnosis of CD is often challenging.
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References
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Corrao G, Corazza GR, Bagnardi V et al (2001) Club del Tenue study Group. Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet 358:356–61
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Multiple Choice Questionnaire
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1)
Celiac disease is
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a.
an allergy
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b.
a temporary condition typical of childhood
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c.
a syndrome characterized by damage to the small intestinal mucosa caused by gliadin
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d.
an infectious disease
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e.
a malabsorption condition related to the pancreas
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a.
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2)
The most frequent complication of celiac disease is
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a.
enteropathy-associated T-cell lymphoma
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b.
refractory sprue
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c.
ulcerative jejunitis
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d.
all of the above
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e.
none of the above
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a.
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3)
The only current treatment for celiac disease is
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a.
immunosuppressant drugs
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b.
a vaccine
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c.
a lifelong, strict, gluten-free diet
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d.
a zonulin inhibitor
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e.
antibodies against IL-15
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a.
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4)
The enteropathy-associated T-cell lymphoma is
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a.
MALT lymphoma
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b.
burkitt-like lymphoma
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c.
T cell lymphoma
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d.
immunoproliferative small intestinal disease (IPSID)
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e.
gastrointestinal stromal tumor
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a.
1. c — 2.d — 3.c — 4.c
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Urgesi, R., Marzo, M., Casale, C., de Vitis, I. (2013). A Case of Unrecognized Complicated Celiac Disease. In: Trecca, A. (eds) Atlas of Ileoscopy. Springer, Milano. https://doi.org/10.1007/978-88-470-5205-5_3
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DOI: https://doi.org/10.1007/978-88-470-5205-5_3
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