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Innervation of the Heart: Imaging Findings Using [123I]-MIBG Scintigraphy in Different Pathologies

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From Basic Cardiac Imaging to Image Fusion

Abstract

Cardiac autonomic innervation plays a key role in maintaining hemodynamic and electrophysiologic harmony. Cardiac sympathetic function is adversely altered in many disease states, such as congestive heart failure, myocardial ischemia, but also in different neurological diseases particularly in patients with parkinsonism. The manuscript consists of a review of how to use cardiac [123I]-MIBG scintigraphy in different cardiac and neurological pathologies in Europe and Japan. The authors demonstrate that a standardization of using [123I]-MIBG around the world is needed in order to obtain normal and abnormal databases. There is accumulating evidence that [123I]-MIBG imaging can help to monitor a patient’s clinical course and response to therapy. The ability to predict potentially lethal ventricular arrhythmias promises to help more accurately select patients for ICD in patients with heart failure. The authors show also that cardiac [123I]-MIBG imaging is also often used in neurological diseases for identifying patients between Parkinson’s disease and multiple system atrophy, and between two common causes of dementia, Alzheimer’s disease and dementia with Lewy bodies.

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Author information

Authors and Affiliations

  1. Nuclear Medicine, University Hospital CHU, Caen, France

    Denis Agostini

  2. Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan

    Kenichi Nakajima

  3. Department of Nuclear Medicine, Amsterdam Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Hein Jan Verberne

Authors
  1. Denis Agostini
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  2. Kenichi Nakajima
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  3. Hein Jan Verberne
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Corresponding author

Correspondence to Denis Agostini .

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Editors and Affiliations

  1. Fondazione Toscana Gabriele Monasterio, Department of Nuclear Medicine, CNR Institute of Clinical Physiology, Pisa, Italy

    Paolo Marzullo

  2. Centro Regionale di Medicina Nucleare, Universita di Pisa, Via Roma 67, Pisa, 56100, Italy

    Giuliano Mariani

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Agostini, D., Nakajima, K., Verberne, H.J. (2013). Innervation of the Heart: Imaging Findings Using [123I]-MIBG Scintigraphy in Different Pathologies. In: Marzullo, P., Mariani, G. (eds) From Basic Cardiac Imaging to Image Fusion. Springer, Milano. https://doi.org/10.1007/978-88-470-2760-2_4

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  • DOI: https://doi.org/10.1007/978-88-470-2760-2_4

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2759-6

  • Online ISBN: 978-88-470-2760-2

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