Abstract
The mechanical behavior of the air spaces in the periphery of the lung is the result of a delicate balance of forces acting on the tissue scaffold of lung parenchyma. Static and dynamic properties of such a complex system have been an important field of research for many years. Alveolar space micromechanics have important physiological implications in terms of mechanical interdependence, alveolar stability, and the maintenance of a gas exchanging surface in constant contact with air. The mechanical behavior of such system has to allow the expansion of the alveolar surface at physiological rates at a low energy cost, and without interfering with the exchange process. I will describe how the structure and mechanics of the alveolar space are particularly optimized to reach these goals.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Wilson TA (1981) The relations among recoil pressure, surface area and surface tension in the lung. J Appl Physiol Respirat Environ Exercise Physiol 50:921–926
Mead J (1961) Mechanical properties of lungs. Physiol Rev 41:281–330
Schürch S, Bachofen H, Weibel ER (1985) Alveolar surface tensions in excised rabbit lungs: effects of temperature. Respir Physiol 62:31–45
Bachofen H, Wilson TA (1991) Micromechanics of the acinus and the alveolar wall. In: Crystal RG, West JB et al (eds) The Lung: scientific foundations. Vol. I. Raven Press, New York, pp 809–819
Pattle RE (1955) Properties, function and origin of the alveolar lining layer. Nature 175:1125–1127
Von Neergard K (1929) Neue Auffassungen über einen Grundbegriff der Atemmechanik: Die Retraktionskraft der Lunge, Abhangig von der Oberflächensprannung in den Alveolen. Z Gesamte Exp Med 66:373–394
Hoppin FG, Hildebrandt J (1977) Mechanical properties of the lung. In: West JB (ed) Bioengineering aspects of the lung. Marcel Dekker, New York, pp 83–157
Schiirch S, Goerke J, Clements JA (1976) Direct determination of surface tension in the lung. Proc Natl Acad Sei 73:4698–4702
Schiirch S, Bachofen H, Goerke J, Possmayer F (1989) A captive bubble method reproduces the in situ behavior of lung surfactant monolayers. J Appl Physiol 67:2389–2396
Wilson TA, Bachofen H (1982) A model of mechanical structure of alveolar duct. J Appl Physiol 53:1512–1520
Smith JC, Stamenovic D (1986) Surface forces in the lungs. I Alveolar surface tension- lung volume relationships. J Appl Physiol 60:1341–1350
Setnikar I, Meschia G (1952) Propieta elastiche del polmone e di modelli meccaniche. Arch Eisiol 52:288–302
Karlinsky JB, Snyder GL, Franzlau C, Stone PJ, Hoppin FG Jr (1960) In vitro effects of elastase and collagenase on mechanical properties of hamster lungs. Am Rev Respir Dis 82:186–194
Moretto A, Dallaire M, Romero P, Ludwig M (1994) Effect of elastase on oscillation mechanics of lung parenchymal strips. J Appl Physiol 77:1623–1629
Romero PV, Canete C, Lopez-Aguilar J, Romero FJ (1998) Elasticity, viscosity and plasticity in lung parenchyma. In: Milic-Emili J (ed) Applied physiology in respiratory mechanics. Springer-Verlag, Berlin Heidelberg New York, pp 57–72
Weibel ER, Crystal RG (1991) Structural organization of the pulmonary interstitium. In: Crystal RG, West JB et al (eds) The lung: scientific foundations. Vol I. Raven Press, New York, pp 369–380
Hildebrandt J (1969) Dynamic properties of air-filled excised cat lungs determined by liquid pletismograph. J Appl Physiol 27:246–250
Romero PV, Robatto FM, Simard S, Ludwig MS (1992) Lung tissue behavior during methacholine challenge in rabbits in vivo. J Appl Physiol 73:207–212
Fredberg JJ, Bunk D, Ingenito E, Shore SA (1993) Tissue resistance and the contractile state of lung parenchyma. J Appl Physiol 74:1387–1397
Navajas D, Maksym GN, Bates JHT (1995) Dynamic viscoelastic nonlinearity of lung parenchymal tissue. J Appl Physiol 79:348–356
Romero F J, Pastor A, Lopez, J, Romero PV (1998) A recruitment-based rheological model for mechanical behavior of soft tissues. Biorheology 35:17–35
Maksym GN, Bates JHT (1997) A distributed nonlinear model of lung tissue elasticity. J Appl Physiol 82:32–41
Takayanagi M (1963) Viscoelastic properties of crystalline polymers. Mem Fac Eng Kyushu Univ 33 (l):41–96
Stamenovic D, Smith JC (1986) Surface forces in lungs IL Microstructural mechanics and lung stability J Appl Physiol 60:1351–1357
Stamenovic D, Wilson TA (1992) Parenchymal stability J Appl Physiol 73:596–602
Romero PV, Lopez Aguilar J, Blanch L (1998) Pulmonary mechanics beyond peripheral airways. In: Milic-Emili J (ed) Applied physiology in respiratory mechanics. Springer-Verlag, Berlin Heidelberg New York, pp 199–210
Romero PV, Rodriguez B, Lopez-Aguilar J, Manresa F (1998) Parallel airways inho- mogeneity and lung tissue mechanics in transition to constricted state in rabbits. J Appl Physiol 84:1040–1047
Hubmayr RD, Hill M, Wilson TA (1996) Nonuniform expansion of constricted dog lungs. J Appl Physiol 80:522–530
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1999 Springer-Verlag Italia, Milano
About this chapter
Cite this chapter
Romero, P.V. (1999). Alveolar micromechanics. In: Milic-Emili, J., Lucangelo, U., Pesenti, A., Zin, W.A. (eds) Basics of Respiratory Mechanics and Artificial Ventilation. Topics in Anaesthesia and Critical Care. Springer, Milano. https://doi.org/10.1007/978-88-470-2273-7_10
Download citation
DOI: https://doi.org/10.1007/978-88-470-2273-7_10
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-0046-9
Online ISBN: 978-88-470-2273-7
eBook Packages: Springer Book Archive