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Serum α-Chemokine CXCL10 and β-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia

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HCV Infection and Cryoglobulinemia

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Abstract

Chemokines are a group of low-molecular-weight peptides that induce the recruitment of leukocytes to sites of inflammation. Among the four major families, CXC chemokines, with CXCL10 as the prototype, display a strong chemo-attractant activity for Th1 lymphocytes and is a reliable marker of Th1-immune mediated diseases. Chemokines from the CC family, with CCL2 as the prototype, are chemo-attractant to Th2 lymphocytes. Our studies demonstrate significantly high serum levels of CXCL10 in patients with MC+HCV with respect to HCV-infected patients without mixed cryoglobulinemia, in particular in the presence of active vasculitis, autoimmune thyroiditis or diabetes. Serum levels of CCL2 in MC+HCV were higher than in controls, but similar to those in HCV-infected patients without mixed cryoglobulinemia. The high levels of CXCL10 in MC+HCV suggest that a Th1 immune process is the immunological base of the association between MC+HCV and the appearance of the above-mentioned disorders. Future studies in larger patient series will be needed to evaluate the relevance of serum CXCL10 as clinico-prognostic marker of MC+HCV, as well as its usefulness in the therapeutic approach to these patients.

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Authors and Affiliations

  1. Metabolism Unit, Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy

    Alessandro Antonelli, Silvia Martina Ferrari, Ilaria Ruffilli, Caterina Mancusi, Ele Ferrannini & Poupak Fallahi

  2. Rheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, Medical School, Modena, Italy

    Clodoveo Ferri & Michele Colaci

Authors
  1. Alessandro Antonelli
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  2. Clodoveo Ferri
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  3. Silvia Martina Ferrari
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  4. Michele Colaci
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  5. Ilaria Ruffilli
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  6. Caterina Mancusi
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  7. Ele Ferrannini
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  8. Poupak Fallahi
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Correspondence to Alessandro Antonelli .

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Editors and Affiliations

  1. , Department of Internal Medicine and Clin, University of Bari, Piazza Giulio Cesare 11, Bari, 70124, Italy

    Franco Dammacco

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Antonelli, A. et al. (2012). Serum α-Chemokine CXCL10 and β-Chemokine CCL2 Levels in HCV-Positive Cryoglobulinemia. In: Dammacco, F. (eds) HCV Infection and Cryoglobulinemia. Springer, Milano. https://doi.org/10.1007/978-88-470-1705-4_17

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  • DOI: https://doi.org/10.1007/978-88-470-1705-4_17

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1704-7

  • Online ISBN: 978-88-470-1705-4

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