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Animal Models of Breast Cancer

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Omics Approaches in Breast Cancer

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Abstract

Several animal models have been used to investigate the etiology and to understand the mechanism of breast carcinogenesis. Advances in cancer management relied on the use of animal models to discover and develop new cancer preventive and therapeutic strategies. Animal models have the advantage of the presence of stromal and 3D structures, which were lacking in the in vitro cell culture preclinical evaluations. Xenograft animal models combined in vitro and in vivo models to overcome the dissimilarity between genetics and other biomarkers of animals and their human counterparts. This chapter will illustrate the various animal models used in breast cancer and their relevance to human breast cancer.

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Authors and Affiliations

  1. Department of Radiation Sciences, Medical Research Institute, Alexandria University, Alexandria, Egypt

    E. A. El-Abd PhD (Faculty of Science)

  2. Biology Department, University of Hail, Hail, Saudi Arabia

    E. A. El-Abd PhD (Faculty of Science)

  3. Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt

    A. S. Sultan PhD

  4. Biochemistry Department, Cairo University, Giza, Egypt

    E. A. Shalaby PhD

  5. Department of Biomedical Sciences, School of Medicine, West Virginia University, Morgantown, WV, USA

    F. Matalkah MSC

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  1. E. A. El-Abd PhD
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  2. A. S. Sultan PhD
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  3. E. A. Shalaby PhD
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  4. F. Matalkah MSC
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Correspondence to E. A. El-Abd PhD .

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Editors and Affiliations

  1. Institute of Integrative Omics, West Bengal, West Bengal, India

    Debmalya Barh

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El-Abd, E.A., Sultan, A.S., Shalaby, E.A., Matalkah, F. (2014). Animal Models of Breast Cancer. In: Barh, D. (eds) Omics Approaches in Breast Cancer. Springer, New Delhi. https://doi.org/10.1007/978-81-322-0843-3_15

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  • DOI: https://doi.org/10.1007/978-81-322-0843-3_15

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