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The Biology of Krüppel-like Factors pp 159–171Cite as

Krüppel-like Factors in the Heart

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Abstract

Despite the development of numerous therapies, heart disease is a major source of morbidity, mortality, and economic burden to society worldwide. A better understanding of the molecular underpinnings that lead to heart failure are likely to facilitate the development of novel therapies. The Krüppel-like factor (KLF) family of zinc finger transcription factors play important roles in modulating cellular functions in a broad range of mammalian cell types, and accumulating evidence demonstrates important roles of these factors in cardiovascular biology. This chapter describes our current understanding of the role of the KLF gene family in cardiac biology and the potential for these factors to serve as therapeutic targets.

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Author information

Authors and Affiliations

  1. Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, University Hospitals Harrington-McLaughlin Heart & Vascular Institute, 2103 Cornell Road, Room 4-522, Cleveland, OH, 44106, USA

    Daiji Kawanami, Saptarsi M. Haldar & Mukesh K. Jain

Authors
  1. Daiji Kawanami
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  2. Saptarsi M. Haldar
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  3. Mukesh K. Jain
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Editor information

Editors and Affiliations

  1. Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ryozo Nagai

  2. Division of Liver Diseases, Mount Sinai School of Medicine, 1425 Madison Avenue Room 1170C, Box 1123, New York, NY, 10029, USA

    Scott L. Friedman

  3. Research Institute, International Medical Center of Japan, 162-8655, Shinjuku-ku, Tokyo, Japan

    Masato Kasuga

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© 2009 Springer

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Kawanami, D., Haldar, S.M., Jain, M.K. (2009). Krüppel-like Factors in the Heart. In: Nagai, R., Friedman, S.L., Kasuga, M. (eds) The Biology of Krüppel-like Factors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87775-2_13

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