Abstract
Glycan-related oligosaccharides involved in a number of biological events. However, there is a paucity of structurally defined oligosaccharides that have been isolated from biological material. Currently, there is a great interest in developing synthetic routes for the oligosaccharide portion of glycoconjugates. The development of simple and effective methods for synthesizing neoglycoconjugates as mimetics of glycoproteins and glycolipids is also essential for the understanding of the biological function of these molecules. Here, we review the recent developments in the synthesis of glycan-related oligosaccharides and neoglycoconjugates.
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References
Harada Y, Murata T, Totani K, Kajimoto T, Masum S-D, Tamba Y, Yamazaki M, Usui T (2005) Design and facile synthesis of neoglycolipids as lactosylceramide and transformation into glycoliposome. Biosci Biotech Biochem 66:801–807
Murata T, Itho T, Usui T (1998) Enzymatic synthesis of β-D-Gal-(1–3)-[β-D-GlcNAc-(1–6)]-α-DGalNAc-OC6H4NO2-p as a carbohydrate unit of mucin-type 2 core. Glycoconjugate J 15:575–5
Murata T, Inukai T, Suzuki M, Yamagishi M, Usui T (1999) Facile enzymatic conversion of lactose into lacto-N-tetraose and lacto-N-neotetraose. Glycoconjugate J 16:189–195
Murata T, Hattori T, Amarume S, Koichi A, Usui T (2003) Kinetic studies on endo-β-galactosidase by a novel colorimetric assay and synthesis of N-acetyllactosamine-repeating oligosaccharide β-glycosides using its transglycosylation activity. Eur J Biochem 270:1–1
Ogata M, Murata T, Murakami K, Suzuki T, Hidari KI, Suzuki Y, Uusi T (2007) Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a γ-polyglutamic acid backbone and their effect for inhibition of infection by influenza viruses. Bioorg Med Chem 15:1383–1393
Totani K, Kubota T, Kuroda T, Murata T, Hidari I-PJK, Suzuki T, Suzuki Y, Kobayashi K, Ashida H, Yamamoto K, Usui T (2003) Chemoenzymatic synthesis and application of glycopolymers containing multivalent sialyloligosaccharides with a poly(L-glutamic acid) backbone for inhibition of infection by influenza viruses. Glycobiology 13:1–12
Yamada S, Suzuki Y, Suzuki T, Le MQ, Nidom CA, Sakai-Tgawa Y, Muramoto Y, Ito M, Kiso M, Horimoto T, Shinya K, Sawada T, Kiso M, Usui T, Murata T, Lin Y, Haire LF, Stevens DJ, Russell RJ, Gambin ST, Skehel JJ, and Kawaoka Y (2006) Hemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptor. Nature 444:378–382
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Murata, T., Usui, T. (2008). Convenient Synthesis of Glycan-Related Oligosaccharides and Their Transformation into Neoglycoconjugates Using Enzymatic Methods. In: Taniguchi, N., Suzuki, A., Ito, Y., Narimatsu, H., Kawasaki, T., Hase, S. (eds) Experimental Glycoscience. Springer, Tokyo. https://doi.org/10.1007/978-4-431-77922-3_1
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DOI: https://doi.org/10.1007/978-4-431-77922-3_1
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-77921-6
Online ISBN: 978-4-431-77922-3
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