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New Frontiers in Lifestyle-Related Diseases pp 57–69Cite as

Cholesterol Trafficking and Esterification With Relation to Atherosclerosis and Neurodegenerative Diseases

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Abstract

Cholesterol is an important lipid molecule that is needed for the growth and viability of mammalian cells. The metabolites of cholesterol include bile acids, oxysterols, and steroid hormones; these substances also have important physiological functions. The sources of cholesterol are from the diet, and from endogenous biosynthesis. Genetically inherited and diet-induced hypercholesterolemia are major risk factors for causing atherosclerotic cardiovascular disease. This Chapter reviews our current knowledge on cellular cholesterol sources and trafficking routes in a mammalian cell. It also reviews the biochemical properties, and the cell biological and pathophysiological roles of the enzyme acyl coenzyme A:cholesterol acyltransferase (ACAT).

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Authors and Affiliations

  1. Department of Biochemistry, Dartmouth Medical School, Hanover, NH, 03755, USA

    Ta-Yuan Chang & Catherine C. Y. Chang

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  1. Ta-Yuan Chang
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  2. Catherine C. Y. Chang
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Editors and Affiliations

  1. Department of Biochemistry, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Akira Miyazaki M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Second Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan

    Michio Imawari M.D., D.M.Sc. (Professor and Chairman) (Professor and Chairman)

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Chang, TY., Chang, C.C.Y. (2008). Cholesterol Trafficking and Esterification With Relation to Atherosclerosis and Neurodegenerative Diseases. In: Miyazaki, A., Imawari, M. (eds) New Frontiers in Lifestyle-Related Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-76428-1_6

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  • DOI: https://doi.org/10.1007/978-4-431-76428-1_6

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-76427-4

  • Online ISBN: 978-4-431-76428-1

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