Abstract
Cholesterol is an important lipid molecule that is needed for the growth and viability of mammalian cells. The metabolites of cholesterol include bile acids, oxysterols, and steroid hormones; these substances also have important physiological functions. The sources of cholesterol are from the diet, and from endogenous biosynthesis. Genetically inherited and diet-induced hypercholesterolemia are major risk factors for causing atherosclerotic cardiovascular disease. This Chapter reviews our current knowledge on cellular cholesterol sources and trafficking routes in a mammalian cell. It also reviews the biochemical properties, and the cell biological and pathophysiological roles of the enzyme acyl coenzyme A:cholesterol acyltransferase (ACAT).
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Chang, TY., Chang, C.C.Y. (2008). Cholesterol Trafficking and Esterification With Relation to Atherosclerosis and Neurodegenerative Diseases. In: Miyazaki, A., Imawari, M. (eds) New Frontiers in Lifestyle-Related Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-76428-1_6
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DOI: https://doi.org/10.1007/978-4-431-76428-1_6
Publisher Name: Springer, Tokyo
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