Abstract
Periodontitis is a choronic inflammatory disease associated with degradation of periodontal tissues. This disease is considered to result of production of proinflammatory cytokines and tissue degradative enzymes which are initiated and advanced by lipopolysaccharide (LPS) of oral bacteria.
Statin, 3-hydroxy-3-mrthylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is known as a drug lowering serum cholesterol. In hyperlipidemia, the increase of cholesterol develops atherosclerosis in blood vessel. Many studies revealed that statins also have the cholesterol-independent, also termed pleiotropic, effects on variety of vascular cells, and decrease the expression level of inflammatory cytokines such as interleukin (IL)-l, IL-6 and IL-8.
As a chronic inflammatory disease, periodontitis shares similar mechanisms with atherosclerosis. We measured the effect of simvastatin, one of statins, on IL-1 and LPS-induced IL-6 and IL-8 production in oral epithelial cells. Simvastatin decreased expression of these inflammatory cytokines and promoter activity of downstream pathway. Our results suggested that statin might be helpful tool for periodontitis.
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References
Beck JD, Offenbacher S (2001) The association between periodontal diseases and cardiovascular diseases: a state-of-the-science review. Ann Periodontol 6:9–15.
Cunha-Cruz J, Saver B, Maupome G, Hujoel PP (2006) Statin use and tooth loss in chronic periodontitis patients. J Periodontol 77:1061–1066
De Nardin E (2001) The role of inflammatory and immunological mediators in periodontitis and cardiovascular disease. Ann Periodontol 6:30–40
Etienne-Manneville S, Hall A (2002) Rho GTPases in cell biology. Nature 420:629–635.
Gutierrez-Venegas G, Kawasaki-Cardenas P, Cruz-Arroyo SR, Perez-Garzon M, Maldonado-Frias S (2006) Actinobacillus actinomycetemcomitans lipopolysaccharide stimulates the phosphorylation of p44 and p42 MAP kinases through CD 14 and TLR-4 receptor activation in human gingival fibroblasts. Life Sci. 78:2577–2583.
Jung YD, Fan F, McConkey DJ, Jean ME, Liu W, Reinmuth N, Stoeltzing O, Ahmad SA, Parikh AA, Mukaida N, Ellis LM (2002) Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine 18:206–213.
Mackman N, Brand K, Edgington TS (1991) Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites. J Exp Med. 174:1517–1526.
Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G (1999) Stimulation of bone formation in vitro and in rodents by statins. Science 286:1946–1949
O’Driscoll G, Green D, Taylor RR (1997) Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial fonction within 1 month. Circulation 95:1126–1231.
Okada H, Murakami S (1998) Cytokine expression in periodontal health and disease. Crit Rev Oral Biol Med 9:248–266
Scannapieco FA, Bush RB, Paju S (2003) Associations between periodontal disease and risk for atherosclerosis, cardiovascular disease, and stroke. A systematic review. Ann Periodontol 8:38–53
Takemoto M, Liao JK (2001) Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 21:1712–1719
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Usui, M. et al. (2008). Statin decreases IL-1 and LPS-induced inflammatory cytokines production in oral epithelial cells. In: Miyazaki, A., Imawari, M. (eds) New Frontiers in Lifestyle-Related Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-76428-1_14
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DOI: https://doi.org/10.1007/978-4-431-76428-1_14
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-76427-4
Online ISBN: 978-4-431-76428-1
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