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Regulation of Retinal Arterial and Arteriolar Tone by Nitric Oxide Derived from Endothelium and Perivascular Nerve

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Nitric Oxide in the Eye

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Abstract

Nitric oxide (NO) is now recognized to be a key substance for regulating functions of not only the cardiovascular, nervous, and immune systems but also other organs and tissues of almost the entire body. The role of NO derived from the endothelium and perivascular nerve has not been well understood in the ocular circulation, possibly because detailed analyses in in vitro studies are difficult in such a small and fragile ocular artery. This chapter describes the role of endothelium-derived NO in isolated retinal central arteries and retinal arterioles in vivo. It also describes the role of NO derived from perivascular nerve in isolated retinal central, ophthalmic, and cerebral arteries and the retinal arterioles in vivo.

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Author notes

  1. Megumi Toda

    Present address: Department of Ophthalmology, Osaka Medical College, Takatsuki, Osaka, 569-8686, Japan

Authors and Affiliations

  1. Department of Pharmacology, Shiga University of Medical Science, Seta, Ohtsu, 520-2192, Japan

    Noboru Toda, Megumi Toda & Tomio Okamura

  2. Toyama Institute for Cardiovascular Pharmacology Research, Toyama Bldg., Azuchi-machi, Chuo-ku, Osaka, 541-0052, Japan

    Noboru Toda

Authors
  1. Noboru Toda
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  2. Megumi Toda
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  3. Tomio Okamura
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Editor information

Editors and Affiliations

  1. Department of Ophthalmology and Visual Sciences Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan

    Satoshi Kashii M.D., Ph.D. (Associate Professor) & Yoshihito Honda M.D., Ph.D. (Professor and Chairman) (Associate Professor) &  (Professor and Chairman)

  2. Department of Pharmacology Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Shimoadachi-cho, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan

    Akinori Akaike Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 2000 Springer-Verlag Tokyo

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Toda, N., Toda, M., Okamura, T. (2000). Regulation of Retinal Arterial and Arteriolar Tone by Nitric Oxide Derived from Endothelium and Perivascular Nerve. In: Kashii, S., Akaike, A., Honda, Y. (eds) Nitric Oxide in the Eye. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67949-3_5

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  • DOI: https://doi.org/10.1007/978-4-431-67949-3_5

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68017-8

  • Online ISBN: 978-4-431-67949-3

  • eBook Packages: Springer Book Archive

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