Chapter

Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor

pp 71-89

Discovery of the Nitromethylene Heterocycle Insecticides

  • Willy D. KollmeyerAffiliated withDuPont Agricultural Products, Stine-Haskell Research Center Email author 
  • , Roger F. FlattumAffiliated with
  • , James P. FosterAffiliated with
  • , James E. PowellAffiliated withDuPont Agricultural Products, Stine-Haskell Research Center
  • , Mark E. SchroederAffiliated withDuPont Agricultural Products, Stine-Haskell Research Center
  • , S. Barney SolowayAffiliated withBiological Sciences Research Center, Shell Agricultural Chemical Company

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Abstract

Structure-activity relationships of the seminal nitromethylene heterocycle (NMH) insecticides have been described previously (Soloway et al. 1979). Rather than recount those observations, this paper describes key events involved in the discovery and exploration of this new class of insecticides along with glimpses of their remarkable chemical and biological properties.