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Ischemic Blood Flow in the Brain pp 151–160Cite as

Microvascular Integrin-Matrix Responses to Focal Cerebral Ischemia Are Rapid and Reflect Neuron Injury

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Part of the book series: Keio University Symposia for Life Science and Medicine ((KEIO,volume 6))

Summary

In the ischemic basal ganglia, early changes in the microvascular basal lamina, cellular integrin expression, and matrix metalloproteinase (MMP) release occur in association with severe neuron injury. These changes are temporally and spatially related. Studies indicate that focal ischemia reduces microvascular expression of endothelial cell integrin α 1 β 1 and astrocyte integrin α 6 β 4 in a manner related to the severity of the neuron injury, and that MMP-2 upregulation is directly related to neuron injury. Further investigations are required to support the proposition that integrin-matrix responses by endothelial cells and astrocytes to focal cerebral ischemia, which together decrease microvascular integrity, also affect neuron survival.

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Author information

Authors and Affiliations

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, MEM 132, La Jolla, CA, 92037, USA

    Gregory J. Del Zoppo, Naohisa Hosomi & Jacinta Lucero

  2. National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan

    Takeo Abumiya

  3. Scripps Clinic, 10666 N. Torrey Pines Road, La Jolla, CA, 92037, USA

    Brian Copeland

  4. Neurologische Klinik, Ludwig-Maximilians-Universitat Munchen, Marchioninistrasse 15, D81377, Munchen, Germany

    Gerhard F. Hamann

  5. Department of Neurology, Yonsei University College of Medicine, CPO Box 8044, Seoul, Korea

    Ji Hoe Heo

  6. National Kyushu Medical Center Hospital, 1-8-1 Jigyohama Chuo-ku, Fukuoka 810, Japan

    Yasushi Okada

  7. National Cardiovascular Center, 5-7-1 Fujishiro-dai, Suita, Osaka 565, Japan

    Masafumi Tagaya

  8. Neurologische Universitat Klinik, OA-Sekretariat, INF 400, Heidelberg, D-69120, Germany

    Simone Wagner

Authors
  1. Gregory J. Del Zoppo
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  2. Takeo Abumiya
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  3. Brian Copeland
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  4. Gerhard F. Hamann
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  5. Ji Hoe Heo
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  6. Naohisa Hosomi
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  7. Jacinta Lucero
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  8. Yasushi Okada
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  9. Masafumi Tagaya
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  10. Simone Wagner
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Editor information

Editors and Affiliations

  1. Department of Neurology School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Yasuo Fukuuchi M.D. (Professor and Chairman), Minoru Tomita M.D. (Visiting Professor) & Atsuo Koto M.D. (Dean, Keio Junior College of Nursing and Professor) (Professor and Chairman),  (Visiting Professor) &  (Dean, Keio Junior College of Nursing and Professor)

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© 2001 Springer Japan

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Del Zoppo, G.J. et al. (2001). Microvascular Integrin-Matrix Responses to Focal Cerebral Ischemia Are Rapid and Reflect Neuron Injury. In: Fukuuchi, Y., Tomita, M., Koto, A. (eds) Ischemic Blood Flow in the Brain. Keio University Symposia for Life Science and Medicine, vol 6. Springer, Tokyo. https://doi.org/10.1007/978-4-431-67899-1_20

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  • DOI: https://doi.org/10.1007/978-4-431-67899-1_20

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67990-5

  • Online ISBN: 978-4-431-67899-1

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