Theory and Practice of Computation

Volume 7 of the series Proceedings in Information and Communications Technology pp 107-115

A Process Algebra Model of Interleukin-2 Trafficking in Hematopoeitic Cells

  • John Justine S. VillarAffiliated withInstitute of Mathematics, University of the Philippines Diliman
  • , Adrian Roy L. ValdezAffiliated withDepartment of Computer Science, University of the Philippines Diliman

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Interleukin-2 (IL-2) is a signaling molecule involved in the development of cellular immunity, and has also been identified as an important regulator in cell proliferation and differentiation in hematopoeitic cells. Furthermore, this has been explored as means of treatment in several disorders, such as melanoma and kidney cancer, among others. In this paper, a model of IL-2 trafficking is presented using stochastic π-calculus. π-calculus is a process algebra that allows the components of a biological system to be modeled independently, rather than modeling the individual reactions. The model simulation is carried out using Stochastic Pi Machine (SPiM), an implementation of stochastic π-calculus using the Gillespie’s algorithm. The proposed model will illustrate the behavior of the ligand system and identify various processes that influence its dynamics.


stochastic π-calculus Interleukin-2 process algebra model