Abstract
The olfactory system in the brain plays key roles in the daily lives of humans and animals. This chapter briefly sketches the recent rapid progress in understanding the structure and function of the olfactory system and some unsolved important questions regarding this system. Olfactory perception occurs in discrete respirations (sniffs), and this chapter underscores the intimate relationship between the function of the olfactory system and the sniff rhythm. In addition, this chapter provides basic knowledge about the unique characteristics of the olfactory neural circuits, starting from olfactory sensory neurons in the nose through the olfactory bulb and olfactory cortex up to the orbitofrontal cortex and olfactory tubercle.
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Amaral D, Lavenex P (2007) Hippocampal neuroanatomy. In: Andersen P, Morris R, Amaral D, Bliss T, O’Keefe J (eds) The hippocampus book. Oxford University Press, New York
Axel R (1995) The molecular logic of smell. Sci Am 273:154–159
Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65:175–187
Buzsaki G (2006) Rhythms of the brain. Oxford University Press, New York
Doty RL (1986) Odor-guided behavior in mammals. Experientia (Basel) 42:257–271
Ekstand JJ, Domroese ME, Johnson DM, Feig SL, Knodel SM (2001) A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy. J Comp Neurol 434:289–307
Fukunaga I, Berning M, Kollo M, Schmaltz A, Schaefer AT (2012) Two distinct channels of olfactory bulb output. Neuron 75:320–329
Gautam SH, Verhagen JV (2012) Retronasal odor representations in the dorsal olfactory bulb of rats. J Neurosci 32:7949–7959
Haberly LB, Price JL (1977) The axonal projection patterns of the mitral and tufted cells of the olfactory bulb in the rat. Brain Res 129:152–157
Heimer L (2003) A new anatomical framework for neuropsychiatric disorders and drug abuse. Am J Psychiatry 160:1726–1739
Homma I, Masaoka Y (2008) Breathing rhythms and emotions. Exp Physiol 93:1011–1021
Igarashi KM, Ieki N, An M, Yamaguchi Y, Nagayama S et al (2012) Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex. J Neurosci 32:7970–7985
Ikemoto S (2003) Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies. J Neurosci 23:9305–9311
Ikemoto S (2007) Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56:27–78
Ikemoto S, Qin M, Liu ZH (2005) The functional divide for primary reinforcement of d-amphetamine lies between the medial and lateral ventral striatum: is the division of the accumbens core, shell, and olfactory tubercle valid? J Neurosci 25:5061–5065
Illig KR (2005) Projections from orbitofrontal cortex to anterior piriform cortex in the rat suggest a role in olfactory information processing. J Comp Neurol 488:224–231
Kepecs A, Uchida N, Mainen ZF (2006) The sniff as a unit of olfactory processing. Chem Senses 31:167–179
Luskin MB, Price JL (1983) The topographic organization of associational fibers of the olfactory system in the rat, including centrifugal fibers to the olfactory bulb. J Comp Neurol 216:264–291
Mainland J, Sobel N (2006) The sniff is part of the olfactory percept. Chem Senses 31:181–196
Manabe H (2008) Behavioral state-dependent coordinated change in the respiration pattern and the signal processing mode in the olfactory cortex and hippocampus. University of Tokyo, Tokyo
Manabe H, Mori K (2013) Sniff rhythm-paced fast and slow gamma-oscillations in the olfactory bulb: relation to tufted and mitral cells and behavioral states. J Neurophysiol 110:1593–1599
Millhouse OE, Heimer L (1984) Cell configurations in the olfactory tubercle of the rat. J Comp Neurol 228:571–597
Mori K, Sakano H (2011) How is the olfactory map formed and interpreted in the mammalian brain? Annu Rev Neurosci 34:467–499
Mori K, Nagao H, Yoshihara Y (1999) The olfactory bulb: coding and processing of odor molecule information. Science 286:711–715
Mori K, Manabe H, Narikiyo K, Onisawa N (2013) Olfactory consciousness and gamma oscillation couplings across the olfactory bulb, olfactory cortex, and orbitofrontal cortex. Front Psychol 4:743
Murakami M, Kashiwadani H, Kirino Y, Mori K (2005) State-dependent sensory gating in olfactory cortex. Neuron 46:285–296
Nagao H, Yoshihara Y, Mitsui S, Fujisawa H, Mori K (2000) Two mirror-image sensory maps with domain organization in the mouse main olfactory bulb. Neuroreport 11:3023–3027
Neville KR, Haberly LB (2004) Olfactory cortex. In: Shepherd GM (ed) The synaptic organization of the brain. Oxford University Press, New York, pp 415–454
O’Keefe J (2007) Hippocampal neurophysiology in the behaving animal. In: Andersen P, Morris R, Amaral D, Bliss T, O’Keefe J (eds) The hippocampus book. Oxford University Press, New York, pp 475–548
Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates. Academic, London
Price JL (1985) Beyond the primary olfactory cortex: olfactory-related areas in the neocortex, thalamus and hypothalamus. Chem Senses 10:239–258
Ray JP, Price JL (1992) The organization of the thalamocortical connections of the mediodorsal thalamic nucleus in the rat, related to the ventral forebrain-prefrontal cortex topography. J Comp Neurol 323:167–197
Shepherd GM, Chen WR, Greer CA (2004) Olfactory bulb. In: Shepherd GM (ed) The synaptic organization of the brain. Oxford University Press, New York, pp 165–216
Shipley MT, Ennis M (1996) Functional organization of olfactory system. J Neurobiol 30:123–176
Switzer RC 3rd, Hill J, Heimer L (1982) The globus pallidus and its rostroventral extension into the olfactory tubercle of the rat: a cyto- and chemoarchitectural study. Neuroscience 7:1891–1904
VanRullen R, Koch C (2003) Is perception discrete or continuous? Trends Cogn Sci 7:207–213
Wachowiak M (2011) All in a sniff: olfaction as a model for active sensing. Neuron 71:962–973
Welker WI (1964) Analysis of sniffing in the albino rat. Behavior 22:223–244
Wilson DA, Sullivan RM (1999) Respiratory airflow pattern at the rat’s snout and an hypothesis regarding its role in olfaction. Physiol Behav 66:41–44
Wilson DA, Sullivan RM (2011) Cortical processing of odor objects. Neuron 72:506–519
Wyatt TD (2009) Fifty years of pheromones. Nature (Lond) 457:262–263
Yamaguchi M, Manabe H, Murata K, Mori K (2013) Reorganization of neuronal circuits of the central olfactory system during postprandial sleep. Front Neural Circuits 7:132
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Mori, K., Manabe, H. (2014). Unique Characteristics of the Olfactory System. In: Mori, K. (eds) The Olfactory System. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54376-3_1
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DOI: https://doi.org/10.1007/978-4-431-54376-3_1
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