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Establishment of a Novel System for Studying the Syk Function in B Cells

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Chembiomolecular Science

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Abstract

The signal through the B-cell antigen-receptor (BCR) complex, which is composed of the BCR itself and the Igα (CD79a)/Igβ (CD79b) heterodimer, is essential for B-cell development and humoral immune responses. The cytoplasmic domains of both Igα and Igβ have an ITAM (immunoreceptor tyrosine-based activation motif), and tyrosine residues in the ITAM are phosphorylated after BCR stimulation followed by the recruitment and activation of protein tyrosine kinases (PTKs). Two classes of the BCR-associated PTK are now defined: Src-PTK such as Lyn, Fyn, Blk, Lck [1–3], and spleen tyrosine kinase, Syk.

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Author information

Authors and Affiliations

  1. Laboratory for Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Tomohiro Kurosaki

  2. RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

    Tomohiro Kurosaki

  3. Department of Laboratory Medicine, University of California, San Francisco, CA, USA

    Clifford A. Lowell

Authors
  1. Tomohiro Kurosaki
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  2. Clifford A. Lowell
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Corresponding author

Correspondence to Tomohiro Kurosaki .

Editor information

Editors and Affiliations

  1. Institute of Microbial Chemistry, Kamioosaki 3-14-23, Tokyo, 141-0021, Japan

    Masakatsu Shibasaki

  2. The University of Tokyo, Department of Pharmacology, Graduate School of Medicine, Hongo 7-3-1, Bunkyo-ku, 113-0033, Japan

    Masamitsu Iino

  3. RIKEN Advanced Science Institute, Antibiotics Laboratory, Chemical Biology Core Facility, 2-1, Hirosawa, Wako, 351-0198, Saitama, Japan

    Hiroyuki Osada

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© 2012 Springer

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Kurosaki, T., Lowell, C.A. (2012). Establishment of a Novel System for Studying the Syk Function in B Cells. In: Shibasaki, M., Iino, M., Osada, H. (eds) Chembiomolecular Science. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54038-0_17

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