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Neurogenesis in the Adult Brain I pp 271–284Cite as

Regulation of Adult Neurogenesis by Environment and Learning

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Abstract

Adult hippocampal neurogenesis is tightly linked to hippocampal ­function. This chapter covers the regulation of adult neurogenesis in response to either a relatively broad cognitive stimulus, an environmental enrichment, or ­specific learning situations. In contrast to more general behavioral stimuli, exemplified by voluntary wheel running, which induce precursor cell proliferation, such cognitive challenges promote the survival of newborn cells, presumably recruiting them for a specific function. Supposedly this function is closely related to the neuronal network, to which the new neurons are added; that is, the mossy fiber connection between the dentate gyrus, as the only location in which adult neurogenesis occurs in the hippocampus, and CA3. The key idea is that activity-dependent regulation of adult neurogenesis allows lifelong optimization of the mossy fiber connection, presumably allowing the system to efficiently respond to novelty and complexity encountered by the individual.

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Authors and Affiliations

  1. Genomics of Regeneration, CRTD – Center for Regenerative Therapies Dresden, DFG Forschungszentrum und Excellenzcluster, Tatzberg 47 – 49, 01307, Dresden, Germany

    Gerd Kempermann

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  1. Gerd Kempermann
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Correspondence to Gerd Kempermann .

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Editors and Affiliations

  1. Department of Histology and Neuroanatomy, Tokyo Medical University, Tokyo, 160-8402, Japan

    Tatsunori Seki Ph.D. (Professor) (Professor)

  2. Department of Developmental and Regenerative Biology, Institute of Molecular Medicine Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan

    Kazunobu Sawamoto Ph.D. (Professor) (Professor)

  3. Department of Neurology, University of Michigan, 109 Zina Pitcher Place 5021 BSRB, Ann Arbor, MI, 48109, USA

    Jack M. Parent M.D. (Associate Professor) & Arturo Alvarez-Buylla Ph.D. (Professor) (Associate Professor) &  (Professor)

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Kempermann, G. (2011). Regulation of Adult Neurogenesis by Environment and Learning. In: Seki, T., Sawamoto, K., Parent, J.M., Alvarez-Buylla, A. (eds) Neurogenesis in the Adult Brain I. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53933-9_11

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