Skip to main content

The Problem of Availability of Patented Drugs Due to Product Patent and Parallel Trade: A Theoretical Approach

  • Chapter
  • First Online:
  • 925 Accesses

Part of the book series: Contributions to Economics ((CE))

Abstract

This chapter examines the effect of the Patent Act on the availability of an essential drug in developing countries. Price discrimination by a Multinational Corporation (MNC) alleviates the problem of non-availability of the drug in a developing country compared to a uniform pricing strategy. Incorporating an upstream-downstream structure, we show that in the presence of parallel trade the MNC can earn a higher profit by serving both the developed and developing countries than by confining its operations in the developed country. Also allowing parallel trade instead of restraining it results in a higher profit to the MNC.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Notes

  1. 1.

    The British Government Department for International Development (Grace 2004) documented that the cost of the manufacturing facility in India that complies with international regulatory norms is about one –fourth of the cost of setting up a similar plant in the US or Europe. Further Civil construction is about US $8–12 per square foot in India compared to US $75 in the US. The cost of an Indian based laboratory analyst/chemist is only one fifth to one eighth of that of a US personnel. In addition, Indian scientists are well trained and equally knowledgeable but earn about one third of the Western counterpart’s salaries.

  2. 2.

    The absence of strict patent regulation always brings the risk of imitation. Historically, Indian imitators are observed to be more cost efficient. This is seen to deter the flow of new technology to India in the process patent regime. With product patent in force, it is expected that MNCs may explore Indian markets with new technology and more technological collaboration can be conjectured.

  3. 3.

    Treatment for exhaustion policies varies from country to country. The European Union pursues regional exhaustion, which means that goods, once purchased, may be freely resold within its frontiers, but parallel imports from non-member countries are excluded. In the US the first sale doctrine is up-held (i.e. rights are exhausted when purchased outside the vertical distribution chain). Parallel Import of pharmaceutical products is permissible in the US provided it satisfies regulatory norms. The International forum on the TRIPS related WTO agreement is however, silent about the issue of parallel trade. Article 7 of the TRIPS agreement clearly emphasizes that its objective is to “contribute to the promotion of technological innovation and to the transfer and dissemination of technology, to the mutual advantage of producers and users of technological knowledge and in a manner conducive to social and economic welfare, and to a balance of rights and obligations”. TRIPS also address, or rather withholds from addressing the issue of parallel imports: none of its provisions, except those pertaining to national treatment and most-favoured-nation treatment is “used to address the issue of intellectual property rights” (Art. 6). In other words, parallel trade remains essentially a matter of national interest.

  4. 4.

    Namely Astra-Zeneca, GlaxoSmithKline and Wyeth Lederle and international trading bodies such as Chemo, Hexal and Mitsui.

  5. 5.

    The incident is widely quoted in a number of sources and is one of the most vivid evidences of parallel trade in the pharmaceutical sector. GlaxoSmithKline sued several participants engaged in parallel trade including the legal parallel trader partner in pharmaceuticals, Dowelhurst Ltd., for trade mark infringement see Gautam Nair 2002; Sarah and Rory 2003; Graham Dukes 2004, Also see case Glaxo Group Ltd vs. Dowelhurst Ltd, [2004] E.T.M.R. 39 (July 31, 2003) available at 2003 WL 21729286 and EWCACiv290 http://www.bailii.org/ew/cases/EWCA/Civ/2004/290.html.

  6. 6.

    The references relate to cases to those of ECJ. See Case C −187/80 Merck & Co. Inc. versus Stephar B.V. and Petrus Stephanus Exler and Joined case C-267-268/95 Merck and Co. Inc. and others versus Princecrown Limited and others.

References

  • Bale HE Jr (1998) The conflicts between parallel trade and product access and innovation: the case of pharmaceuticals. Journal of International Economic Law 1(4):637–53

    Article  Google Scholar 

  • Chaudhuri S (2005) The WTO and the India’s pharmaceuticals industry. Oxford University Press, New Delhi

    Google Scholar 

  • Chaudhuri S (2003) Generic competition, price control and affordability of drugs in India, Working Paper, 478, Indian Institute of Management, Calcutta

    Google Scholar 

  • Danzon PM, Chao LW (2000) Does regulation drive out competition in pharmaceutical markets? 210 J Law Econ 43(2):311–357.

    Google Scholar 

  • Danzon P, Kim J (1998) International price comparisons for pharmaceuticals: measurement and policy issues. Pharmacoeconomics 14(1):15–25

    Article  Google Scholar 

  • Danzon PM, Towse A (2003) Differential pricing for pharmaceuticals: reconciling access, R&D and patents. International Journal of Health Care Finance and Economics 3:183–205

    Article  Google Scholar 

  • Danzon PM, Furukawa MF (2003) Prices and availability of pharmaceuticals: evidence from nine countries, Health Affairs Web Exclusive October 29

    Google Scholar 

  • Fink, C. (2000) ‘Entering the Jungle of Intellectual Property Rights Exhaustion and Parallel Importation’, in Intellectual Property and Development Lessons From Recent Economic Research Fink Carsten et.al., (eds), World Bank and Oxford University Press, Oxford, 165–200

    Google Scholar 

  • Gallus N (2004) The mystery of pharmaceutical parallel trade and developing countries. The Journal of World Intellectual Property 7(2):169–183

    Article  Google Scholar 

  • Ganslandt M, Maskus KE (2003) Vertical restraints, distribution, and the price impact of parallel imports: implications for the European Union and Sweden. In: Lundvall K (ed) High prices in Sweden – a result of poor competition? Swedish Competition Authority, Stockholm, pp 160–223

    Google Scholar 

  • Ganslandt M, Maskus KE (2007) Vertical distribution, parallel trade, and price divergence in integrated markets. European Economic Review 51(4):943–970

    Article  Google Scholar 

  • Ganslandt M, Maskus KE (2004) The price impact of parallel trade in pharmaceuticals: evidence from the European Union. Journal of Health Economics 23:1035–1057

    Article  Google Scholar 

  • Gautam N (2002) Profiteers divert to Europe AIDS drugs meant for Africa. Asian Wall Street Journal. 7 October, at A9

    Google Scholar 

  • Grace C (2004) The effect of changing intellectual property on pharmaceutical industry prospect for India and China, technological transfer and access to medicine. Department for International Development (DFID), Health System Resource Centre, London

    Google Scholar 

  • Graham D (2004) Interim report of task force 5 working group on access to essential medicines 32 UN Millennium Project, 1 February

    Google Scholar 

  • Kanavos P, Costa-i-Font J (2005) Pharmaceutical parallel trade in Europe: stakeholder and competition effects. Economic Policy 20(44):751–798

    Article  Google Scholar 

  • Kanavos, P, J Costa-i-Font S Merkur and M Gemmill (2004) The Economic Impact of Pharmaceutical Parallel distribution in the European Union Member Studies: A stakeholder analysis, London School of Economics (LSE) Health and Social Care, London.

    Google Scholar 

  • Lanjouw, J.O. (1997) ‘The Introduction of Product Patents in India: 'Heartless Exploitation of the Poor and Suffering?’, Economic Growth Center Discussion Paper, no 775, Yale University. 1–56.

    Google Scholar 

  • Majumdar M and M Rajeev (2010) ‘Efficiency of Manufacturing Firms in India: A Non-Radial Approach’ Centre de Sciences Humaines, Occasional paper, (Forthcoming).

    Google Scholar 

  • Marjit S, Beladi H (1998) Product versus Process Patents. Journal of Policy Modeling 20(2):193–199

    Article  Google Scholar 

  • Maskus KE (2000) Parallel Imports: Global Trade Policy. The World Economy 23(9):1269–1284

    Article  Google Scholar 

  • Maskus, K. E. (2001) ‘Parallel imports in PharmaceuticalError! Bookmark not defined.: Implications for competitionError! Bookmark not defined. and prices in developingError! Bookmark not defined. countries’, Final Report to World Intellectual Property Organization

    Google Scholar 

  • Maskus KE, Chen Y (2002) Parallel imports in a model of vertical distribution: theory, evidence, 525 and policy. Pac Econ Rev 7:319–334.

    Article  Google Scholar 

  • McConaghie, A. (2002) ‘Parallel trade: is Pharma fighting a losing battle?’ Pharma Focus. July5.

    Google Scholar 

  • National Economic Research Associates (1999) The Economic Consequences of the Choice of Regime of Exhaustion in the Area of Trademarks. NERA, London

    Google Scholar 

  • Sarah B, Rory C (2003) Profiteers resell Africa’s cheap aids drugs. Guardian, 4 Oct 2003, P1.

    Google Scholar 

  • Shy O (1995) Industrial Organization: Theory and Application. MA The MIT Press, Cambridge

    Google Scholar 

  • Pérez-Casas, C. (2000) ‘HIV/AIDS Medicines Pricing Report, Setting objectives: is there a political will?’ Update: December, [online]. Available at www.accessmed-msf.org

  • Watal J (1999) Introducing Product Patents in the Indian Pharmaceutical Sector: Implications for Prices and Welfare. World Competition 20:5–21

    Google Scholar 

  • Watal J (2000) Pharmaceutical Patents, Prices and Welfare Losses: Policy Options for India Under the WTO TRIPS Agreement. The World Economy 23(5):733–752

    Article  Google Scholar 

  • West P, Mahon J (2003) ‘Benefits to payers and patients from parallel trade’ York Health Economics Consortium. York, May

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mainak Mazumdar .

Appendix A

Appendix A

7.1.1 Deterring Parallel Trade

MNCs can also counter parallel trade by strategically pricing its product. In fact, the potential for parallel trade emerges when there is a large price differential for the medicine between the two markets. The manufacturer can however, “choke off” the potential for parallel trade by charging a price in a way such that the lower uniform price of the developing country prevails in the developed market. The manufacturer then sets \( p_A^W \) in such a way that the retail price of the medicine are the same in the market of \( {M_{{dl}}} \) and \( {M_d} \) or in other words p B = p A. With p B = p A however the incentive for parallel trade is curbed. To set the same retail price for both the countries \( {p^A} = \frac{{{a_1} + P_A^W}}{2}{ } \) should be equal to \( \frac{{3{a_2} + c}}{4} \) or in other word

$$ { }\frac{{{a_1} + P_A^W}}{2} = \frac{{3{a_2} + c}}{4} $$
(A.1)
$$ \Rightarrow P_A^W = \frac{{3{a_2} + c - 2{a_1}}}{2} $$
(A.2)

At price, \( { }P_A^W = \frac{{3{a_2} + c - 2{a_1}}}{2} \) the retail price for the medicine in country \( {M_d} \) is \( \frac{{3{a_2} + c}}{4} \) and there is no scope for parallel trade. The quantity that is demanded

$$ {q^A} = \frac{{4{a_1} - 3{a_2} - c}}{4} $$
(A.3)

By charging the low price of the developing country, the profit that the manufacturer earns from the country \( {M_d} \)

$$ {\Pi_{{Md}}} = \frac{{(3{a_2} - c - 2{a_1})(4{a_1} - 3{a_2} - c)}}{8} $$
(A.4)

Let \( { }\Pi_U^M \) be the total profit the manufacturer earns (from the developed and the developing market) by charging the lower uniform price of the developing country in the developed world. Therefore

$$ \Pi_U^M = \left[ {{\Pi_{{Md}}} = \left\{ {\frac{{(3{a_2} - c - 2{a_1})(4{a_1} - 3{a_2} - c)}}{8}} \right\} + \Pi_M^{{{M_{{dl}}}}} = \frac{{{{({a_2} - c)}^2}}}{8}} \right] $$
(A.5)

If \( \Pi_P^M \;>\; \Pi_U^M \), the manufacturer earns higher profit by accommodating parallel trade than by deterring it by charging the lower uniform price of \( {M_{{dl}}} \).

Cross-multiplying and simplifying the terms of \( \Pi_P^M \) and \( { }\Pi_U^M \) we get the following expressions \( 5a_1^2 + 6{a_1}{a_2} - 12{a_1}c - 12{a_2}c + 14{c^2} + 3a_2^2 \) and \( 108{a_1}{a_2} - 48a_1^2 - 12{a_1}c - 12{a_2}c + 12{c^2} - 48a_2^2 \)

$$ \therefore \Pi_P^M - \Pi_U^M = 53a_1^2 + 51a_2^2 + 8{c^2} - 102{a_1}{a_2} $$
(A.6)

For \( \Pi_P^M \;>\; \Pi_U^M \), we need to show that

$$ \begin{array}{lll} 53a_1^2 + 51a_2^2 + 8{c^2} \;>\; 102{a_1}{a_2} \hfill \cr \Rightarrow 53a_1^2 + 51a_2^2 - 102{a_1}{a_2} + 8{c^2} \;>\; 0 \hfill \cr \Rightarrow 2a_1^2 + 8{c^2} + {(\sqrt {{51}} a_1 - \sqrt {{51}} a_1)^2} \;>\; 0 \end{array} $$
(A.7)

which is always true. From the above result, we therefore conclude that for all values of \( {a_1}{ } \) and \( { }{a_2} \) the strategy of accommodating parallel trade dominates the strategy of deterring parallel trade.

Table A.1 Comparison of retail prices of selected generic products across countries in the year 2002–2003 (prices converted into Indian rupees, conversion rate of exchange considered 1USD = Rs 45.50,1 GBP = Rs 83.51 1 PAK Rs = Rs.84 and 1 Indonesian Rp = Rs.005)

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mazumdar, M. (2013). The Problem of Availability of Patented Drugs Due to Product Patent and Parallel Trade: A Theoretical Approach. In: Performance of Pharmaceutical Companies in India. Contributions to Economics. Physica, Heidelberg. https://doi.org/10.1007/978-3-7908-2876-4_7

Download citation

Publish with us

Policies and ethics