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Influenza Virus Sialidase - A Drug Discovery Target pp 131–151Cite as

Clinical Experience with Influenza Virus Sialidase Inhibitors

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Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

The clinical experience of influenza virus sialidase inhibitors has been relatively limited, although over the past 5 years a number of studies have been undertaken that demonstrate the efficacy and indeed the potential issues of these drugs. This chapter provides an overview of aspects of this clinical experience including the current clinical use of these drugs, role of laboratory, pharmacological aspects of these antiviral drugs, as well as treatment and chemoprophylaxis in different infection scenarios (e.g. seasonal epidemics versus pandemics).

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Acknowledgements

We would like to thank Prof. Frederick G. Hayden for his very valuable comments and kind assistance.

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  1. Institut Pasteur in Cambodia, Virology Unit, 5 Monivong blvd, 983, Phnom Penh, Cambodia

    Philippe Buchy

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  1. Gold Coast Campus, Inst. Glycomics, Griffith University, Parklands Drive, Southport, 4215, Queensland, Australia

    Mark von Itzstein

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Buchy, P. (2012). Clinical Experience with Influenza Virus Sialidase Inhibitors. In: von Itzstein, M. (eds) Influenza Virus Sialidase - A Drug Discovery Target. Milestones in Drug Therapy. Springer, Basel. https://doi.org/10.1007/978-3-7643-8927-7_7

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