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The Hygiene Hypothesis and Darwinian Medicine pp 45–75Cite as

Immunoregulation by microbes and parasites in the control of allergy and autoimmunity

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Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Key changes in our microbial environment, encompassing mycobacteria, helminth worms and commensal microflora, may each have had a major impact on the development and reactivity of our immune system not only to infections, but also in the context of harmless antigens in autoimmunity and allergy. We discuss here recent advances in understanding host-microbe and host-parasite interactions, and their impact on the balance between immunoregulation and immunopathology in the mammalian immune system.

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Authors and Affiliations

  1. Institute of Immunology and Infection Research, West Mains Road, Edinburgh, EH9 3JT, UK

    Rick M. Maizels

  2. Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria

    Ursula Wiedermann

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  1. Rick M. Maizels
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  2. Ursula Wiedermann
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  1. Centre for Infectious Diseases and International Health Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London, W1T 4JF, UK

    Graham A. W. Rook

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Maizels, R.M., Wiedermann, U. (2009). Immunoregulation by microbes and parasites in the control of allergy and autoimmunity. In: Rook, G.A.W. (eds) The Hygiene Hypothesis and Darwinian Medicine. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8903-1_3

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