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Immune regulation in atherosclerosis and the hygiene hypothesis

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The Hygiene Hypothesis and Darwinian Medicine

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. The hygiene hypothesis implies that dysregulation of the immune response has led to increased susceptibility to immuno-inflammatory diseases. Recent studies established that subtypes of T cells, regulatory T cells, actively involved in the maintenance of immunological tolerance, inhibit the development and progression of atherosclerosis. Here, we review the immune regulatory pathways of atherosclerosis and discuss the potential implication of pathogens and their associated molecular patterns in the regulation of the immuno-inflammatory response of atherosclerosis.

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Authors and Affiliations

  1. Paris Cardiovascular Research Center, INSERM and Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 75015, Paris, France

    Hafid Ait-Oufella, Alain Tedgui & Ziad Mallat

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  1. Hafid Ait-Oufella
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  2. Alain Tedgui
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  3. Ziad Mallat
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Editors and Affiliations

  1. Centre for Infectious Diseases and International Health Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London, W1T 4JF, UK

    Graham A. W. Rook

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© 2009 Birkhäuser Verlag Basel/Switzerland

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Ait-Oufella, H., Tedgui, A., Mallat, Z. (2009). Immune regulation in atherosclerosis and the hygiene hypothesis. In: Rook, G.A.W. (eds) The Hygiene Hypothesis and Darwinian Medicine. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8903-1_12

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