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Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy pp 191–209Cite as

Potential novel treatments for bipolar depression

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Part of the book series: Milestones in Drug Therapy ((MDT))

Abstract

Existing pharmacological treatments for bipolar disorder (BPD), a severe recurrent mood disorder, is in general insufficient for many patients. Despite adequate doses and treatment duration, many individuals afflicted with this disease continue to experience mood episode relapses, residual symptoms, and functional impairment. In contrast to the manic phase of the illness where a fairly large variety of effective treatments are available, in bipolar depression effective therapeutics are scarce. This is especially troubling because the long-term course of BPD is dominated by recurrent depressive episodes and lingering depressive symptoms rather than hypomanic/manic episodes. Novel therapeutics—that is, drugs that do not include the existing antipsychotic, antiepileptic, and antidepressant medications—currently being studied to determine their efficacy and safety in bipolar depression include modafinil, pramipexole, N-acetyl cysteine (NAC), scopolamine, agomelatine, riluzole, memantine, ketamine, AMPA potentiators, ketoconazole, mifepristone, celecoxib, creatine, and uridine RG2417. Further study of these drugs will investigate their clinical utility in bipolar depression, and further our understanding of relevant drug targets.

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  1. Laboratory of Molecular Pathophysiology & Experimental Therapeutics, Mood and Anxiety Disorders Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Carlos A. Zarate Jr & Husseini K. Manji

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  1. Carlos A. Zarate Jr
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  1. Mood Disorders Research Unit Laboratory of Molecular Pathophysiology, National Institute of Mental Health Mark O. Hatfield Clinical Research Center, Unit 7SE Rm. 7-3445 10 Center Drive, Bethesda, Maryland, 20892, USA

    Carlos A. Zarate

  2. Laboratory of Molecular Pathophysiology, National Institute of Mental Health Porter Neuroscience Research Center, Building 35, Room 1C-917 36 Convent Drive, MSC 3711, Bethesda, Maryland, 20892, USA

    Husseini K. Manji

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Zarate, C.A., Manji, H.K. (2009). Potential novel treatments for bipolar depression. In: Zarate, C.A., Manji, H.K. (eds) Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy. Milestones in Drug Therapy. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8567-5_12

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