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The lymphocyte in inflammatory angiogenesis

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Angiogenesis in Inflammation: Mechanisms and Clinical Correlates

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

The ability of immune cells to recognise foreign pathogens, while simultaneously maintaining tolerance towards proteins produced by the body’s own cells, forms the basis of mammalian immunity. At the heart of the immune system are the lymphocytes, which orchestrate the adaptive immune response through clonal expansion upon recognition of a specific antigen. The plasticity of the immune system allows exquisite control of the body’s defences. However, the adaptive immune system can also be directed towards host proteins (‘self antigens’). The reasons for this failure in immunity are varied, and include a genetic basis or evasion of the host immune response by viruses. Nevertheless, the consequences — autoimmune diseases such as rheumatoid arthritis (RA) — are frequently associated with inflammation, immune cell dysfunction and changes in the vasculature.

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Author information

Authors and Affiliations

  1. Kennedy Institute of Rheumatology, Faculty of Medicine, Imperial College, London, UK

    Ewa Paleolog & Mohammed Ali Akhavani

  2. Division of Surgery, Oncology, Reproductive Biology & Anaesthetics, Faculty of Medicine, Imperial College, London, UK

    Ewa Paleolog

  3. Restoration of Appearance and Function Trust (RAFT), Mount Vernon Hospital, The Leopold Muller Building, Northwood, Middlesex, UK

    Mohammed Ali Akhavani

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  1. Ewa Paleolog
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Editors and Affiliations

  1. Centre for Experimental Medicine and Rheumatology William Harvey Research Institute, St. Bartholomew’s Hospital, Charterhouse Square, London, E1M 6BQ, UK

    Michael P. Seed

  2. Academic Rheumatology, University of Nottingham, Clinical Sciences Building City Hospital Hucknall Road, Nottingham, NG5 1PB, UK

    David A. Walsh

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Paleolog, E., Akhavani, M.A. (2008). The lymphocyte in inflammatory angiogenesis. In: Seed, M.P., Walsh, D.A. (eds) Angiogenesis in Inflammation: Mechanisms and Clinical Correlates. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7650-5_4

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