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Systems Biological Approaches in Infectious Diseases pp 1–20Cite as

Systems biology and its impact on anti-infective drug development

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Part of the book series: Progress in Drug Research ((PDR,volume 64))

Abstract

Systems biology offers the potential for more effective selection of novel targets for anti-infective drugs. In contrast to conventional reductionist biology, a systems approach allows targets to be viewed in a wider context of the entire physiology of the cell, with the potential to identify key susceptible nodes and to predict synergistic effects of blocking multiple pathways. In addition to the holistic perspective provided by systems biology, the emphasis on quantitative analysis is likely to add further rigour to the process of target selection. Systems biology also offers the potential to incorporate different levels of information into the selection process. Consideration of data from microbial population biology may be important in the context of predicting future drug-resistance profiles associated with targeting a particular pathway, for example. This chapter provides an overview of major themes in the developing field of systems biology, summarising the core technologies and the strategies used to translate datasets into useful quantitative models capable of predicting complex biological behaviour.

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Author information

Authors and Affiliations

  1. Centre for Integrative Systems Biology at Imperial College (CISBIC), Division of Molecular Biosciences, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK

    Michael P. Stumpf

  2. Centre for Integrative Systems Biology at Imperial College (CISBIC), Department of Molecular Microbiology and Infection, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK

    Brian D. Robertson, Ken Duncan & Douglas B. Young

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  1. Michael P. Stumpf
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  2. Brian D. Robertson
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  3. Ken Duncan
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  4. Douglas B. Young
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Editor information

Editors and Affiliations

  1. Tuberculosis Research Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, Rockville, MD, 20852, USA

    Helena I. Boshoff  & Clifton E. Barry III  & 

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© 2007 Birkhäuser Verlag

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Stumpf, M.P., Robertson, B.D., Duncan, K., Young, D.B. (2007). Systems biology and its impact on anti-infective drug development. In: Boshoff, H.I., Barry, C.E. (eds) Systems Biological Approaches in Infectious Diseases. Progress in Drug Research, vol 64. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-7567-6_1

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