Skip to main content
SpringerLink
Log in

Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat Parkinsonian models with 6-hydroxydopamine

  • Conference paper
Neurosurgical Re-Engineering of the Damaged Brain and Spinal Cord

Part of the book series: Acta Neurochirurgica Supplements ((NEUROCHIRURGICA,volume 87))

  • 236 Accesses

Summary

The aim of the present study was to investigate the alteration of neuronal activities in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), after ipsilateral STN lesioning by kainic acid in the rat hemi-parkinsonian 6-hydroxydopamine (6-OHDA) model. In various rat parkinson’s disease (PD) models, an increase in the SNpr firing rate was observed, despite the occurrence of bursting patterns, and subthalamic lesion was found to reduce the mean firing rates and the percentage of bursting neurons in the SNpr. However, the relative proportion of bursting neurons, among all GP neurons, was slightly increased as a result of the subthalamic lesion. The significance of bursting activity in the SNpr and GP remains obscure. Further study is necessary to elucidate the pathophysiological mechanism behind parkinson’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Abbreviations

PD :

Parkinson’s disease

6-OHDA :

6-hydroxydopamine

STN :

subthalamic nucleus

MFB :

medial forebrain bundle

SN :

substantia nigra

L-DOPA :

L-3,4-dihydroxyphenylalanine

DA :

dopamine

References

  1. Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neuroci 12: 366–375

    Article  CAS  Google Scholar 

  2. Alexander GE, Crutcher MD, DeLong MR (1990) Basal ganglia thalamocortical circuits: parallel substrates or motor, oculomotor, ‘prefrontal’ and limbic1 functions. Prog Brain Res 85: 119–146

    Article  PubMed  CAS  Google Scholar 

  3. Aziz TZ, Peggs D, Sambrook MA, Crossman AR (1991) Lesion of the subthalamic nucleus for the alleviation of I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. Mov Disord 6: 288–292

    Article  PubMed  CAS  Google Scholar 

  4. Benabid AL, Koudsie A, Benazzouz A, Vercueil L, Fraix V, Chabardes S, LeBas JF, Pollak P (2001) Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in Parkinson’s disease. Extension to new indications such as dystonia and epilepsy. J Neurol 248 [Suppl] 3: III/37–III/47

    Google Scholar 

  5. Benazzouz A, Gao DM, Ni ZG, Piallat B, Bouali-Benazzouz R, Benabid AL (2000) Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat. Neuroscience 99: 289–295

    Article  PubMed  CAS  Google Scholar 

  6. Benazzouz A, Gross C, Geger J, Boraud T, Bioulac B (1993) Reversal of rigidity and improvement in motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys. Eur J Neurosci 5: 382–389

    Article  PubMed  CAS  Google Scholar 

  7. Bergman H, Wichmann T, DeLong MR (1990) Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 249: 1436–1438

    Article  PubMed  CAS  Google Scholar 

  8. Burbaud P, Gross C, Benazzouz A, Coussemacq M, Bioulac B (1995) Reduction of apomorphine-induced rotational behaviour by subthalamic lesion in 6-OHDA lesioned rats is associated with a normalization of firing rate and discharge pattern of pars reticulata neurons. Exp Brain Res 105: 48–58

    Article  PubMed  CAS  Google Scholar 

  9. Chang JW, Wachtel SR, Young D, Kang UJ (1999) Biochemical and anatomical characterization of forepaw adjusting steps in rat models of parkinsons disease: studies on medial forebrain bundle and striatal lesions. Neuroscience 88: 617–628

    Article  PubMed  CAS  Google Scholar 

  10. Chang JW, Lee BH, Lee MS, Chang JH, Park YG, Chung SS (2001) Microelectrode Recording-Guided Deep Brain Stimulation in Patients with Movement Disorders (The First Trial in Korea). In: Lultas-Ilinsky K, Ilinsky IA (eds) Basal ganglia and thalamus in health and movement disorders. Kluwer Academic/ Plenum Publishers, New York, pp 341–347

    Chapter  Google Scholar 

  11. Delfs JM, Ciaramitaro VM, Parry TJ, Chesselet MF (1995) Subthalamic nucleus lesions: widespread effects on changes in gene expression induced by nigrostriatal dopamine depletion in rat. J Neurosci 15:6562–6575

    PubMed  CAS  Google Scholar 

  12. Delong MR (1990) Primate model of movement disorders of basal ganglia origin. Trends Neurosci 13: 281–285

    Article  PubMed  CAS  Google Scholar 

  13. Hamada I, DeLong MR (1992) Excitotoxic acid lesions of the primate subthalamic nucleus result in transient dyskinesias of the contralateral limbs. J Neurophysiol 68: 1850–1858

    PubMed  CAS  Google Scholar 

  14. Hassani OK, Mouroux M, Feger J (1996) Increased subthalamic neuronal activity after nigral dopaminergic lesion independent of disinhibition via the globus pallidus. Neuroscience 72:105–115

    Article  PubMed  CAS  Google Scholar 

  15. Hollerman JR, Grace AA (1992) Subthalamic nucleus firing in the 6-OHDA treated rat: basal activity and responses to haloperidol. Brain Res 590: 291–2991

    Article  PubMed  CAS  Google Scholar 

  16. Hutchinson WD, Allan RJ, Opitz H, Levy R, Dostrovsky JO, Lang AE, Lozano AM (1998) Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson’s disease. Annals Neurol 44: 622–628

    Article  Google Scholar 

  17. Kreiss DS, Mastropietro CW, Rawji SS, Walters JR (1997) The response of subthalamic nucleus neurons to dopamine receptor stimulation in a rodent model of Parkinson’s disease. J Neurosci 17:6807–6819

    PubMed  CAS  Google Scholar 

  18. Kumar R, Lozano AM, Kim YJ, Hutchison WD, Sime E, Halket E, Lang AE (1998) Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson’s disease. Neurology 51: 850–855

    Article  PubMed  CAS  Google Scholar 

  19. Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, Benabid AL (1998) Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. New Eng J Med 339: 1105–1111

    Article  PubMed  CAS  Google Scholar 

  20. MacLeod NK, Ryman A, Arbuthnott GW (1990) Electrophysiological properties of nigrothalamic neurons after 6-hydroxytryptamine lesions in the rat. Neuroscience 38: 447–456

    Article  PubMed  CAS  Google Scholar 

  21. Meissner W, Reum T, Paul G, Harnack D, Sohr R, Morgenstern R, Kupsch A (2001) Striatal dopaminergic metabolism is increased by deep brain stimulation of the subthalamic nucleus in 6-hydroxydopamine lesioned rats. Neurosci Lett 303: 165–168

    Article  PubMed  CAS  Google Scholar 

  22. Nakao N, Ogura M, Nakai K, Itakura T (1998) Intrastriatal mesencephalic grafts affect neuronal activity in basal ganglia nuclei and their target structures in a rat model of Parkinson’s disease. J Neurosci 18: 1806–1817

    PubMed  CAS  Google Scholar 

  23. Ni Z, Bouali-Benazzouz R, Gao Dongming, Benabid AL, Benazzouz A (2000) Changes in the firing pattern of globus pallidus neurons after the generation of nigrostriatal pathway are mediated by the subthalamic nucleus in the rat. Eur J Neurosci 12: 4338–4344

    PubMed  CAS  Google Scholar 

  24. Pan HS, Walters JR (1988) Unilateral lesion of the nigrostriatal pathway decrease the firing rate and alters the firing pattern of globus pallidus neurons in the rat. Synapse 2: 650–656

    Article  PubMed  CAS  Google Scholar 

  25. Porter RHP, Greene JG, Higgins Jr DS, Greenamyre JT (1994) Polysynaptic regulation of glutamate receptors and mitochondrial enzyme activities in the basal ganglia of rats with unilateral dopamine depletion. J Neurosi 14: 7192–7199

    CAS  Google Scholar 

  26. Robledo P, Feger J (1990) Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data. Brain Res 518: 47–54

    Article  PubMed  CAS  Google Scholar 

  27. Rohlfs A, Nikkhah G, Rosenthal C, Rundfeldt C, Brandis A, Samii M, Loscher W (1997) Hemispheric asymmetries in spontaneous firing characteristics of substantia nigra pars reticulata neurons following unilateral 6-hydroxydopamine lesion of the rat nigrostriatal pathway. Brain Res 761: 352–356

    Article  PubMed  CAS  Google Scholar 

  28. Ryan LJ, Clark KB (1992) Alteration of neuronal responses in the subthalamic nucleus following globus pallidus and neostratal lesions in rats. Brain Res Bull 29: 319–327

    Article  PubMed  CAS  Google Scholar 

  29. Ruskin DN, Bergstrom DA, Mastropietro CW, Twery MJ, Walters JR (1999) Dopamine agonist-mediated rotation in rats with unilateral nigrostriatal lesions is not dependent on net inhibitions in basal ganglia output nuclei. Neuroscience 91: 935–946

    Article  PubMed  CAS  Google Scholar 

  30. Sanderson P, Mavoungou R, Albe-Fessard D (1986) Changes in substantia nigra pars reticulata activity following lesions of the substantia nigra pars compacta. Neurosci Lett 67: 25–30

    Article  PubMed  CAS  Google Scholar 

  31. Tseng KY, Kasanetz F, Kargieman L, Pazo JH, Murer MG, Riquelme LA (2001) Subthalamic nucleus lesions reduce low frequency oscillatory firing of substantia nigra pars reticulata neurons in a rat model of Parkinson’s disease. Brain Res 904: 93–103

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Medical Research Center, Brain Korea 21 project for Medical Science & Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea

    Jin Woo Chang M.D., M. F. Jeon, B. H. Lee & S. S. Chung

  2. Graduate School of East-West Science, Kyung Hee University, Seoul, Korea

    J. S. Yang

Authors
  1. Jin Woo Chang M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. S. Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. F. Jeon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. H. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. S. Chung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jin Woo Chang M.D. .

Editor information

Editors and Affiliations

  1. Department of Neurological Surgery, Nihon University, School of Medicine, Tokyo, Japan

    Y. Katayama

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Wien

About this paper

Cite this paper

Chang, J.W., Yang, J.S., Jeon, M.F., Lee, B.H., Chung, S.S. (2003). Effect of subthalamic lesion with kainic acid on the neuronal activities of the basal ganglia of rat Parkinsonian models with 6-hydroxydopamine. In: Katayama, Y. (eds) Neurosurgical Re-Engineering of the Damaged Brain and Spinal Cord. Acta Neurochirurgica Supplements, vol 87. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6081-7_34

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-6081-7_34

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-7223-0

  • Online ISBN: 978-3-7091-6081-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation