Abstract
Skin acts as an essential barrier, protecting organisms from their environment. Loss of the integrity of large portions of the skin as a result of injury may lead to major disability or even death. Adult skin consists of two tissue layers: a keratinized, stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissue providing support and nourishment. Appendages such as hair and glands are derived from the epidermis, but they project deep into the dermal layer. Thus, skin replacement has been and remains a challenging task for surgeons ever since the introduction of skin grafts by Reverdin in 1871.
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Gauglitz, G.G. (2013). The Use of Dermal Substitutes in Dermatosurgery. In: Kamolz, LP., Lumenta, D. (eds) Dermal Replacements in General, Burn, and Plastic Surgery. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1586-2_11
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DOI: https://doi.org/10.1007/978-3-7091-1586-2_11
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