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Brain Edema XV pp 31–38Cite as

High-Mobility Group Box 1: An Amplifier of Stem and Progenitor Cell Activity After Stroke

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Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 118))

Abstract

Stroke induces a highly complex web of pathophysiology that usually leads to serious long-term ­disability. Molecules from the damage-associated molecular pattern (DAMP) family immediately increase after stroke. DAMPs are known to cause massive inflammation and brain damage. Thus, they may be targets for neuroprotection. However, emerging data now suggest that DAMPs may not always be detrimental. The high-mobility group box1 (HMGB1) protein is discussed as an example of this idea. During the acute phase after stroke, HMGB1 amplifies neuroinflammation. But during the brain remodeling phase of stroke recovery, HMGB1 can mediate beneficial plasticity and enhance stem and progenitor cell recruitment, proliferation, and differentiation within damaged brain. These emerging findings support the hypothesis that HMGB1 might be an important molecule for regulating stem and progenitor cell therapies in stroke patients.

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Acknowledgments

Supported in part by NIH grants, the American Heart Association, the Deane Institute.

Conflict of InterestWe declare that we have no conflict of interest.

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Authors and Affiliations

  1. Neuroprotection Research Laboratory, Harvard Medical School, Massachusetts General Hospital East, 149-2401, Charlestown, MA, 02129, USA

    Kazuhide Hayakawa, Loc-Duyen D. Pham, Ken Arai & Eng H. Lo

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  1. Kazuhide Hayakawa
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  2. Loc-Duyen D. Pham
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  3. Ken Arai
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  4. Eng H. Lo
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Correspondence to Eng H. Lo .

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Editors and Affiliations

  1. School of Medicine, Dept. Neurological Surgery, Nihon University, Oyaguchikami-machi 30-1, Tokyo, 173-8610, Japan

    Yoichi Katayama

  2. School of Medicine, Departments of Neurological Surgery and, Nihon University, 30-1 Oyaguchi Kamimachi, Itabashi-ku, Tokyo, 173-8610, Japan

    Takeshi Maeda

  3. , Department of Clinical Laboratory, Namegata District General Hospital, 98-8 Inouefujii, Namegata 98-8, Ibaraki, 311-3516, Japan

    Toshihiko Kuroiwa

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Hayakawa, K., Pham, LD.D., Arai, K., Lo, E.H. (2013). High-Mobility Group Box 1: An Amplifier of Stem and Progenitor Cell Activity After Stroke. In: Katayama, Y., Maeda, T., Kuroiwa, T. (eds) Brain Edema XV. Acta Neurochirurgica Supplement, vol 118. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1434-6_5

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  • DOI: https://doi.org/10.1007/978-3-7091-1434-6_5

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