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Oxidative Stress Components Explored in Anoxic and Hypoxic Global Gene Expression Data

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Book cover Low-Oxygen Stress in Plants

Part of the book series: Plant Cell Monographs ((CELLMONO,volume 21))

Abstract

Global gene expression data were analyzed to search for the genes related to oxidative stress response, to examine the differences between hypoxia and anoxia, and to reveal new components of oxygen deprivation response escaped from the previous analyses. Gene Set Z-score (GSZ) was used to report gene ontology (GO) classes that showed significant regulation and also partial up- and downregulation in Arabidopsis anoxic and hypoxic microarray data sets. Under both anoxia and hypoxia significant upregulation was reported for anaerobic respiration, response to low oxygen levels, and response to hypoxia. Comparable high GSZ scores were shown for several oxidative stress-related GO classes and for functional groups of biological processes known to involve oxygen radical formation such as: cellular respiration, wounding, and response to high light and UV-B. Availability of oxygen in hypoxic experimental sets was marked by upregulation of several oxygenases, including ACC-oxidase responsible for ethylene synthesis. Consistent strong induction of several Fe-dependent ketoglutarate oxygenases (FeKGO) in the majority of hypoxic conditions analyzed suggests an important and yet unidentified function for these enzymes. Based on metabolic and gene expression studies we suggest that FeKGO may function in a bypass route for part of the TCA cycle (citrate-isocitrate) inhibited under hypoxia. This would incorporate 2-ketoglutarate supplied by activated GABA shunt and form succinate, a TCA cycle and mitochondrial electron transport chain substrate. FeKGO turnover is sustained by the putative route coupled to ascorbate–monodehydroascorbate cycling and hemoglobin-dependent NO elimination. The analysis strongly supports earlier findings that formation of activated oxygen and oxidative stress is an integral part of the response to oxygen deprivation. Several novel functional gene groups were highlighted by the analysis: upregulation of cysteamine dioxygenase activity and FeKGO and downregulation of circadian rhythm-related genes.

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Acknowledgments

We wish to thank Julia Bailey-Serres, Joost van Dongen, Pierdomenico Perata, and Chiara Pucciariello for supplying the microarray datasets for our analysis. This work was supported by the Academy of Finland grant no. 123826.

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Authors and Affiliations

  1. Department of Biosciences, Division of Plant Biology, University of Helsinki, Helsinki, Finland

    Olga B. Blokhina & Kurt V. Fagerstedt

  2. Institute of Biotechnology, University of Helsinki, Helsinki, Finland

    Petri Törönen

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  1. Olga B. Blokhina
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  2. Petri Törönen
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Correspondence to Olga B. Blokhina .

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Editors and Affiliations

  1. RWTH Aachen University, Aachen, Germany

    Joost T. van Dongen

  2. Scuola Superiore Sant´Anna, Pisa, Italy

    Francesco Licausi

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Blokhina, O.B., Törönen, P., Fagerstedt, K.V. (2014). Oxidative Stress Components Explored in Anoxic and Hypoxic Global Gene Expression Data. In: van Dongen, J., Licausi, F. (eds) Low-Oxygen Stress in Plants. Plant Cell Monographs, vol 21. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1254-0_2

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